Full Life Extension Data from Interventions Testing Program (ITP)

[RapAdmin]

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ITP has a good website with their life extension data.

ITP: https://phenome.jax.org/projects/ITP1

Compounds info: https://phenome.jax.org/projects/ITP1/compounds

A simple practice guide for dose conversion between animals and human

And the main National Institutes on Aging ITP Program Website:

Interventions Testing Program (ITP)

[EnrQay]

MPD: ITP data portal

Rapa, acarbose (for men), and 17-a-estradiol (for men) really stand out here. Rapa is the most compelling, of course. Others I missed?

Other Compelling Anti-aging Drugs - Acarbose, Canagliflozin (SGLT2 inhibitor), 17a-Estradiol

While there are probably hundreds of compounds, if not thousands, that have some kind of evidence supporting the idea that they may provide some sort of anti-aging benefits, most of them have at most been tested only in lower level organisms (e.g. flies, worms, etc.), not in large, repeatable double-blind, placebo controlled studies in mammals. Its mildly interesting to see a drug or supplement increasing the lifespan in a fly (here for example), or c.elegans worm, or even a mouse in a single study. But it starts to get a lot more interesting when the compound is a drug that is already FDA approved, has been used for years by humans, and there are well-designed, placebo controlled studies which have been duplicated in a number of different labs with similar results. And even better when…