I don’t know of any that are available. Figure 11 in this study shows a few compounds that have been studied besides ALT-711.
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Unluckily for us Rifampicin is hepatotoxic. Has anyone tried it?
Any other way to fight AGEs? In this podcast the researcher commented they were successful in reverting arterial stiffness with alagebrium. But it was a weak effect. Maybe we need a lifelong dosis?
I can’t find the reference now as it was so long ago but already looked into it and low doses were not hepatoxic. Also my main interest would be in snorting it or nebulizing it with a brain safe solvent — need to look into the pharmacology of it, what it’s soluble in, etc. and hopefully I don’t have to skunk work it as last time I checked researchers were already working on trials with intranasal delivery.
You are totally right! Nasal delivery prevents liver enzime from rising and you also need a much smaller dose.
Medilabo RFP is the company that it’s starting human trials. Funny that resveratrol is coming back to the scene:
Are you planning on taking it?
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It’s on the horizon for me over the next few years but not right away. I’d have to do a lot more research as to how best take it. If there were an intranasal spray of it already on the market from a pharmaceutical company I’d take it asap.
AAA enhancement in diabetic mice by aminoguanidine or alagebrium treatment promoted elastin degradation, smooth muscle cell depletion, mural macrophage accumulation, and neoangiogenesis without affecting matrix metalloproteinases,
Treatment With Small Molecule Inhibitors of Advanced Glycation End-Products Formation and Advanced Glycation End-Products-Mediated Collagen Cross-Linking Promotes Experimental Aortic Aneurysm Progression in Diabetic Mice - PubMed
This means that the breakdown of glucosepane cross-links can potentially be harmful because these cross-links have already become an integral part of the tissues. Their removal may disrupt the structure and function of the tissues, which could lead to dangerous consequences such as weakened blood vessels and organ damage.
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@Olafurpall I saw in another thread that you take R-ALA, do you take it mainly for its anti-glycation function? What do you think of rosmarinic acid?
I don’t take R-ALA specifically for glycation. I’m not aware of any evidence that it inhibits glycation directly, although it could certainly reduce glycation indirectly in some people by reducing blood glucose. I take R-ALA mainly because of the studies that show that it’s important for maintaining mitochondrial function with aging. R-ALA is produced naturally in the cells of the body but you start producing less and less around middle age, maybe after age 30, and that contributes to mitochondrial dysfunction with aging. Several studies in the early 2000’s showed that R-ALA helped improve mitochondrial function in aging, in particular if combined with acetyl-l-carnitine. Here is one of these studies: Efficacy of levo carnitine and alpha lipoic acid in ameliorating the decline in mitochondrial enzymes during aging - PubMed
Regarding rosmarinic acid, I don’t have much of an opinion on it since it’s not a compound I have researched a lot. That said, I do recall coming across several studies indicating that it is beneficial and I think it’s likely one of the compounds responsible for the health benefits of spices like rosmarin.
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Another HDAC inhibitor
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