The first aceclidine-based eye drop to improve near vision in adults with presbyopia, which affects more than 100 million adults in the US alone, has been approved by the Food and Drug Administration (FDA) and will be available within three months.
Known as VIZZ, from pharmaceutical company LENZ, the drops are an aceclidine ophthalmic solution that effectively treats presbyopia in adults. The once-daily drops offer relief from blurry near. vision for up to 10 hours.
The company:
WHAAAATTT??? This is too good to be true… I’m sending this to my eye doc first thing in the morning to see what he says.
Another magic liquid, like the German cartilage filler, that brings credit to science, and to the FDA for approving it.
Sounds similar to Vuity eyedrops.
Yes
A review of Vuity:
Vuity, taken daily, promises clear vision for up to 10 hours. But does it work?
I’ve found that Lutein and Zeaxanthin plus Astaxanthin has kept my presbyopia at bay. Also a good night sleep. I can read everything in the morning, but by the evening my presbyopia comes back. I take Lutein and Zeaxanthin in the morning. Maybe I need to take it twice daily?
FWIW my eye doc said:
The main issue is possible retinal detachment (oh, just that!). The previous version had a non-insignificant rate of retinal detachment and also has a lot of side effects (and tried it once and he himself experienced them).
Hmmm… you mean that I could dump my cheaters with these drops?
Sign me up.
BTW, I just corrected this message… now that I can read typos… 
I was so excited about this until I realized you have to keep using them a couple times a day.
Has anyone seen pricing yet?
And my guess is they might not work if you’ve had cataract surgery?
According to the Times article provided by Rapadmin, it’s $100 for a month’s supply. It also gives you pinkeye.
A revolutionary drug that will make presbyopia a thing of the past. Also, from what I’ve read, its active ingredient is aceclidine. It doesn’t have the side effects of other anticholinergics, such as focusing impairment. Surprisingly, it’s specific only to the muscle fibers that enable near vision. I wish the company continued success. I wonder if they could have developed the drug using artificial intelligence.
Great. another wonder drug that has serious side effects. (retina detachment and other side effects Beth reports). I think I’ll pass and stay on the sidelines watching this for awhile. (it may have been the earlier drug that caused these effects?)
I think it was the older medication Vuity:
but perhaps also rarely with the new medication Vizz:
specifically:
Risk of Retinal Tear/Detachment: Rare cases of retinal tears and detachments have been reported with medications that cause the pupils to constrict or become smaller. Examination of the retina is advised in all patients before using these eye drops. Patients should be advised to seek immediate medical care with the sudden onset of vision loss, flashing lights, or floaters.
Thx. I think I’ll just “keep an eye” on it for awhile…
Fwiw, my eye doc is expecting the retinal detachment risk with VIZZ.
It’s also expected to cause some of the same side effects he saw with the Vuity and some occured in the trials. He tried Vuity and everything went dark. VIZZ mentions 16% had dim vision.
Lenz Therapeutics submitted a new drug application (NDA) to the FDA back in August 2024, and the FDA accepted the submission in October.3,4The submission was based on data from the Clarity clinical trial series, which included 3 randomized, double-masked, controlled phase 3 trials that investigated the safety and efficacy of aceclidine for the treatment of presbyopia.
Clarity 1 and Clarity 2 investigated the safety and efficacy of aceclidine 1.44% in 466 participants dosed once daily for 42 days; meanwhile, Clarity 3 evaluated the long-term safety of the drop across 6 months of once-daily dosing in 217 patients. All primary and secondary end points were reached across Clarity 1 and 2, and the drop produced consistent near vision improvements across both trials. The formulation was well-tolerated and no serious treatment-related adverse events were observed across all 3 trials. The most commonly reported adverse events include irritation at the instillation site (20%), dim vision (16%), and headache (13%). Less commonly, some patients experienced conjunctival hyperemia (8%) and ocular hyperemia (7%). Lenz reported that most adverse events were mild, transient, and self-resolving.
On webmd
Retinal Detachment. Vizz works by making your pupils smaller, a process called miosis. There have been rare reports of retinal detachment with other medicines that cause miosis in people who already have an existing disease of the retina. A retinal detachment is when the light-sensitive layer at the back of the eye (retina) separates from its normal position. If not treated quickly, this can cause permanent vision loss. Your health care provider may want you to have an eye exam before you use this medicine. Get emergency help if you have any of the following symptoms of a retinal detachment.
Seems not to be contrindicated for anyone with classic LASIK for distance vision (like me, back in 2000), so yeah - retinal tears aside - this is magic bullet territory if it delivers.
Will be seeing my ophthalmologist for a full eye exam this Friday and plan to request a VIZZ prescription. Last eye exam was when I heavy dosed Rapamycin and had clogged duct… about 2.5 years ago.
If all goes well, I should be able to provide a VIZZ review to, Y’all soon!
I am a native Texan… living in Missouri. Lol
“Miosis”. ha; that brought back some memory’s! As a military pilot, miosis was a subject area we knew about due to the fact that being exposed to minute amounts of nerve agents causes miosis. So it was a condition we were taught to look out for when in combat zones. Wonder if the drug has some type of nerve agent in it…?
I found an optometrist both FAAO and IALVS certified, (highest educational level) who spent an hour fitting me with new glasses that helped me pass the DMV vision exam. She saved my life.
I think I’ll have to move to a 20/60 state. But I refuse to retire to - the “land of the blind” - 20/70 Florida.