Yes, I’m aware. I do work out, preferring HIIT, but I’m a skinny guy and I don’t use creatine. I doubt that Cystatin C would make a difference.
Steve,
How does Cagrilintide work for you? Does it stop your hunger, cause nausea, or just stop your desire for food?
I ask because so far my favorite glp is retatrutide. It blunts a decent amount of my cravings and l get satisfied on less food but l still get hunger pangs 3 to 4 hours later though.
Like most things, it’s dose dependent. It was developed to specifically curb hunger to enhance the poor weight loss performance of semaglutide. And “poor” is relative to the newer GLP1’s like tirz and reta.
When I first tried Cagri I started at too high a dose, 1.0mg and it killed all hunger for 3 or 4 days, did not care at all about eating. So not sure if that is “hunger” or “desire” but maybe a bit more on the desire side of the equation. Just did not enjoy eating and did not feel hungry.
I’ve never experienced nausea with any GLP1 and none with Cagri either. Very few of our local clients have experienced nausea with GLP1 either, I’d say less than 0.3%
I’m just trying to curb the THC induced munchies a bit more than reta does 
Reta is still my go to GLP1 and it will continue to be for the foreseeable future.
I’m not terribly concerned about feeling hungry, that just reminds us we are human It’s how one deals with that feeling that matters. I’m hungry every day when I get home from work, enjoy a nice meal and feel full, another human reaction
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I was thinking about this after I wrote it. Not entirely true as I have experienced nausea under very specific conditions, over eating when I was on Tirz. If I ate a larger than “normal” meal I would experience some nausea for a bit. That was in the first 8 months of this journey. With Reta that doesn’t happen, I can enjoy a nice steak and not feel that. I’m just not sure if it was the GLP1 type or if my system has become fully acclimated to the new normal.
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Great info Steve. Thanks
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This is disappointing… but I guess to be expected:
Study shows how fast kilos return after ending weight-loss drugs
When people stop taking the new generation of weight-loss drugs they pile back on the kilos four times faster than they would after ending diet and exercise regimens, new research found Thursday.
But this was mostly because they lost so much weight in the first place, according to the British researchers who conducted the largest and most up-to-date review of the subject.
A new generation of appetite-suppressing, injectable drugs called GLP-1 agonists have become immensely popular in the last few years, transforming the treatment for obesity and diabetes in many countries.
They have been found to help people lose between 15-20% of their body weight.
“This all appears to be a good news story,” said Susan Jebb, a public health nutrition scientist at Oxford University and co-author of a new BMJ study.
However, recent data has suggested that “around half of people discontinue these medications within a year,” she told a press conference.
This might be because of common side effects such as nausea or the price—these drugs can cost over $1,000 a month in the US.
So the researchers reviewed 37 studies looking at ceasing different weight-loss drugs, finding that participants regained around 0.4 kilograms a month.
Six of the clinical trials involved semaglutide—the ingredient used in Novo Nordisk’s brands Ozempic and Wegovy—and tirzepatide used for Eli Lilly’s Mounjaro and Zepbound.
While taking these two drugs, the trial participants lost an average of nearly 15 kilograms.
However after stopping the medication, they regained 10 kilograms within a year, which was the longest follow-up period available for these relatively new drugs.
https://medicalxpress.com/news/2026-01-fast-kilos-weight-loss-drugs.html
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I feel the same disappointment when looking at my ldl numbers after 1 month off statins
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The way I see this class of drugs is that they need to be taken for life. The upside to it is the fact that they’re not just weight loss drugs, they do have other positive synergetic effects for health, so no harm done if taken forever. I can attest to both, the rapid weight gain if stopped and to other benefits (besides weight loss). The other good thing about them the fact that they are dirt cheap, about $100 per year (thanks to our Chinese friends) for a decent maintenance dose i.e. 3mg Reta, or 5mg Tirze per week.
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Maybe they’re not stopping especially because of the side effects (a very small number might) but I think they might be stopping prescriptions and going to gray as the gray market has exploded in last couple years. I know two people that did just that.
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I figured out the problem with the PDF - I had not used my typical guardrail text (only use reputable journals, no blogs, clinics, influencers or youtube) and that eliminated a bad link that was 1 of 43 links in the original PDF.
This new PDF has only 30 reference links and passes Avast scan.
What effect does GLP1-RA’s have on the mTOR system (1).pdf (371.3 KB)
This PDF is deemed unsafe by my browser and I can’t open or read it. What’s the source?
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There are 46 papers referenced in the PDF and that was the problem, one of those links was bad, not sure which one so I re-did the PDF using my typical guardrail
Lesson learned, if you don’t use guardrails with AI it is very possible to acquire bad reference links.
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