I’ve intermittently taken it on and off (2mg/day but with many breaks) and it doesn’t result in feminization. This is way higher than the microdoses of 17-alpha that Bryan Johnson has done…
You can also stop it once you notice the first signs of breast growth.
I vote no. You did not state your frequency or body weight. This might be a huge dose for you. Do you want enlarged breasts and fat deposits on your hips and thighs, not to mention bloating and mood swings, among other things? Those things might happen, given enough time.
Might be worth it if you were a post-menopausal woman worried about brain shrinkage and you had an academic job, or one in the creative arts. Then again, eschewing it hasn’t seemed to hurt Marin Alsop’s performing, or any number of women in creative fields.
I am not even sure that 17-alpha-estradiol is completely non-feminizing in humans. I think the more appropriate classification would be “not as” feminizing as the beta enantiomer. But I think it’s doing a number on Bryan Johnson with his choices for attire and nail polish, etc…
I think it is also unclear as to how much benefit 17-alpha-estradiol could provide to human males. I am not even sure about mice. C57BL 6 are prone to obesity and type-2 diabetes. Would any benefit be muted in mice (or people) who are not so prone?
You can have at hand a SERM which would reverse any breast growth.
Female longevity on average vs. male should be studied more, what’s causing the difference.
For example Tamoxifen.
While I wouldn’t mind softer skin, I’m wary of estrogen’s effects on fertility, breast development and muscle mass. Topical alfatradiol in larger amounts already made my breast tissue hurt for some reason.