Nicely solved, Eric & Team @BuckInstitute
After they are made, proteins take on new functions when they are attached to chemicals called acyls. Histone acetylation is a well-known modification that regulates genes, a change that may accelerate aging. How acyls attached non-enzymatically was unclear. Now we know. A molecule called “CoA” takes them there. Interestingly: elevating CoA levels protects against brain aging in mice & may improve memory
Acetly coa is at the core of most age related diseases. Thats why long genes dont work as well.
So what is the best way to increase these levels?
It is quite complicated overall and I am working with a few people with coached biohacking to do this (as I have mentioned before) Part of it is improved mitochondrial efficiency, however. That is how Rapamycin can help.
My patent, however, will publish in October 2023 (the initial application went in last April and it publishes 18 months after that). In the mean time people need to sign an NDA and disclaimer and agree to do tests (which they pay for themselves - they don’t pay me) if they wish to join the protocol.
I wish you success! I hope you are able to advance aging research and longevity.
It definitely does something. Exactly how much and exactly how to handle the side effects is another issue. However, I do weekly blood tests for myself and I am at the forefront of the protocol. CRP at under 0.16mg/L, Cystatin C at 0.89 mg/L and HbA1c at 4.18% (much that this probably excludes the labile part) are quite positive biomarkers.
And all whilst eating not particularly healthy full English breakfast and not exactly holding back on the booze - you must be doing something right!!!
I think you are right in your analysis. I am focussing on the biochemistry. I am still careful about how much I eat, but the balance of what I eat is not what would be considered an orthodox longevity diet.
Similarly I do some exercise on an exercise frame (not particularly good chinups and failures of pullups etc), but apart from brisk walking I probably only do about 5 minutes of exercise a day.
Last night was the first drinking night for a week, however. I will compare the blood test I did yesterday to the one I had last friday to see if I can identify any changes (particularly on urate). I am likely to go back on the wagon, however. Although I do have a rather tempting half bottle of nice port sitting around.