Forum member “mTORdocTOR” mentioned this paper in another thread. Am posting as an individual post as some people may not see or go to the original posting/Twitter link.
Thank you “mTORdocTOR”
From the paper;
“We found that NK at a dose of 10,800 FU/day effectively managed the progression of atherosclerosis and hyperlipidemia with a significant improvement in the lipid profile. A significant reduction in the thickness of the carotid artery intima-media and the size of the carotid plaque was observed. The improvement rates ranged from 66.5 to 95.4%. NK was found to be ineffective in lowering lipids and suppressing atherosclerosis progression at a dose of 3,600 FU/day.”
This was the study that made me think Natto might not work:
But they used 2000fu.
Lustgarten does a chapter on the effects of LDL, HDL, CRP and fibrinogen. He concludes by saying"
When considering that fibrinogen levels are significantly correlated with the amount of bacteria found in blood, these data collectively support the hypothesis that CRP,LDL, and fibrinogen may increase during aging to protect against an increased microbial burden, but with the negative consequence of contributing to cardiovascular disease.
So it is a tough call on what to do here.
Also I don’t know of any randomized controlled studies on Rapa in humans and longevity. Yet it is known to be pretty safe. So it is your life and your gamble.
I’ll repeat my concern that nattokinase and serrapeptase may not to be very effective unless they are enteric coated. I won’t offer an opinion on lumbrokinase except to say that I’d want to see considerable evidence of safety before I used it routinely. Nattokinase and serrapeptase have been used by many people for many years, but IIRC lumbrokinase is significantly more potent as a thrombolytic agent, and there are good reasons (i.e. hemorrhages, including hemorrhagic stroke) why you might not want to use such agents casually.
Still another supplement when taken in the therapeutic range causes me excessive gassiness, along with Acarbose, trehalose, erythritol, etc.
Unfortunately, maybe because I am old, there are many supplements cannot take because they mess with my digestive system. What I can take daily without the digestive consequences that some others experience is up to two tbsps of EVOO and C8 oil.
So I will be skipping Nattokinase
The dose required for it to be effective are high, and judging by the price, that would be an expensive way to prevent ascvd. We’re also not sure if this is a dirty drug, meaning if it has any offtargets effects.