Does oversupplementing with antioxidants cause reductive stress?

#1

GSH can, but what about other antioxidants?

The most common cause of reductive stress is excess NADH/NADPH, which is different from, say, extra amounts of melatonin/ascorbic acid/C60/conjugated double bonds. Dayan Goodenowe discusses some implications of excess NADH/NADPH in his “breaking autism” webinars

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#2

One data point on antioxidants…

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#3

BUT WHAT KIND? Vitamin C/E yes, ALA yes, but glutathionine-based antioxidants have been shown to be neutral-to-beneficial, as with melatonin.

IT DEPENDS ON THE KIND

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#4

Yes - some seem helpful, not sure if the mechanism is the antioxidant property…

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#5

Vitamin C is harmful? I thought excess is excreted. @TongMD said vitamin C is a pro-oxidant.