Qualia Senolytic represents the culmination of years of research into the biological mechanisms of aging. This two-day rejuvenation regimen may hold the key to unlocking cellular health and revitalizing aging tissues throughout the body.
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Looking at the list it has a number of HDAC inhibitors and AMPK activators so it probably does have an effect.
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The site claims it is clinically tested/scientific proven. I find no real evidence.
I find no dosage info or concentration of the individual components. The asterixis seem to lead nowhere. True there are known components like quercetin and fisetin that are used and tested for example in combination with dasatinib but for me that is insufficient proof these are the magic pills (capsules) we are looking for.
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How do you view the authenticity of their research report? Thank you!
Thank you for this link. It does work!!
please also take notice of the last sentence:
*These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure or prevent any disease. The information on this site is for educational purposes only and should not be considered medical advice. Please speak with an appropriate healthcare professional when evaluating any wellness related therapy. Please read the full medical disclaimer before taking any of the products offered on this site.
Sofar they may have proven results for treating joint discomfort.
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It reads like a waste of money to me.
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There’s still lot of uncertainty among senolytics researchers whether removing senescent cells is a net positive or if it is always a net positive.
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As a bit of a senolytic aficionado, I’ve done a few competitive analysis on senolytics. I’ve been taking our current formula since 2019 and have seen it move the needle backwards with every person who has done our evaluation protocol. So it appears to “work” or at least have an effect on epigenetic markers related to various age related measurements.
After a covid infection, our “ages” increased at the next test. After 3 cycles our ages went back to the prior levels. covid is pro aging and creates a lot of senescent cells in the process, especially in the lungs. Interestingly my recent upgrade to our Tru test data shows that my lungs are the youngest organs in my body!
There are some first principles related to senolytics;
- Dose matters
- Bio-availability matters
- Selected compounds matter
- Consumption protocol matters, i.e. timing
I could write a couple pages on each of those 4 and provide informative studies that support those 4 first principles. But to keep this short, lets do this first 
Like most longevity/healthspan protocols there is a fair bit of confusion in this space because it is a complex process, senescence. And what has been demonstrated to “work” in more than a few clinical studies including 2 Phase 1 trials, is often mis-understood with regard to those 4 first principles. Dose being one of the most egregious errors in most formulas.
To do this analysis you must “standardize” the compounds provided to the amount used in the successful clinical trials. The dose is much higher than most companies provide. Because it is expensive to provide the proper dose and most companies target a specific monthly cost over effectiveness and ride the hype to the bank.
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I am not certain that senolytics always remove senescent cells. I think they may often be moreso senomorphic in that they make senescent cells function correctly.
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Zombie Cells - senescent cells are very similar to the sci-fi creatures
- There is not 1 senescent cell type.
- Senescent cells reside in pretty much every tissue strata
- Senescent cells are made “on demand”
- Senescent cells accumulate with age
1 & 2) Keep in mind as you go through this, there is no universal senolytic that can clear all senescent cells in all tissue types. The senolytics commonly available (including ours) only work in 2 tissue types 1) adipose tissues and 2) endothelial tissues. Every cell type except 1 (red blood cells) become senescent. This tells us that senescent cells are present in the various layers of the skin, in epithelial tissues, adipose tissues, cardiac tissues, muscles tissues, your eyes, your ears, etc. 240 cell types make up our body.
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Pretty much any insult to the body will generate fresh senescent cells; sun burn, cuts, bruises, torn ligaments, smoking, etc. BUT not all senescent cells are created by insults, it’s likely that more are created by other functions that are degrading as we age, mitochondrial dysfunction, cellular communication errors, genetic replication errors, etc. We can never be without senescent cells regardless of our attempts to clear them out. I don’t see any reason to be afraid of trying to mange senescent cell burden as we age. That is called the Threshold Theory of Senescence.
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When we are young, pre 30’s, our immune system keeps our senescent cell burden under control by clearing out excess senescent cells. As we age our immune system is not working like it did and the immortal senescent cells hang around longer without good house keeping. There is a cascade effect with senescent cells. The more you have the more that are created. Why is that? Because the SASP (senescence associated secretory phenotype), tells us there are at least 4 recruiting chemokines. Yes, just like zombies that live forever, senescent cells recruit nearby healthy cells to become senescent. One begets two, 2 beget 4 and the cascade ramps up as it attacks our immune system. Yes our Immune system becomes “immunosenescent”.
It’s been estimated that by the time we die (assuming old age) we can easily have 5kg of senescent cells in our body. Autopsies and biopsies on damaged vertebral disks show that as much as 40% of a damaged disk is made up of senescent cells.
In other words, you will never be without senescent cells, regardless of what you do to eliminate them.
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I think a lot of senescent cells are cells that get stuck in the process of differentiation. There is good evidence for this. Hence ideally you want to get them through the process of differentiation. They get stuck because of a shortage of acetyl-CoA and there are a number of ways of attacking that. (including using HDAC inhibitors so that the shortage of acetyl-CoA does not prevent transcription).
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Thank you for your reply. So, are you taking QUALIA SENOLYTIC?
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No I take my own formula EternLFX, the one that I used as the standard in that analysis.
I spent several years 2018-2019 reading every study and paper on senescence and senolytics I could find, over 150 of them. I have a criteria to invest my time in an intervention. I found that it met my criteria of;
- does it provide a benefit - enough studies say yes
- can I do it - with a bit of work, yes I can
- if I can’t do it, I move on to something I can do
The 12 Hallmarks of Aging are interactive. Each of the 12 has an impact or is impacted by other Hallmarks. Senescence interacts with 9 of the 12. The next highest in the regard is Inflammaging at 7 interaction and then Mitochondrial dysfunction and Genomic instability at 6.
What I have found is that my body responds positively to all the additional things I try. When in the past it did not. So I consider killing zombie cells one of those foundational protocols, while it may not make me “feel” something it sure does measure well in my Trudiagnostic test as it did with everyone else who followed the protocol
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These would be 3 of the more important papers on senolytics and senescence. A good starting point for anyone interested in this topic.
When a simple protocol has an impact on 2 very different disease conditions, it is worth a bit of effort to understand it. I tell people to pick there favorite disease and tack senesence on and do a google search “heart disease senescence” “dementia senescence” “cancer senescence”
It is important to understand that senescence is a two edged sword, one edge will hurt you, the other edge will help you.
First evidence that senolytics are effective at decreasing senescent cells in humans
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(19)30641-3/fulltext
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(19)30591-2/fulltext
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(18)30629-7/fulltext
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- Senolytics
- Senomorphics
- Senotherapeutics
Three areas of senescence research.
My “philosophy” on this is that my body will make senescent cells until the day I die, so I know I won’t be without them.
I know I only need a few and that of the 36 trillion cells only a “few” will become senescent. They will not go extinct like the dodo bird.
So I prefer to clear out some (again there is no universal senolytic and you can’t clear them all out with any known therapy today) and let my body replace them (which it does) with new healthy cells instead of trying to recover already defective cells.
It looks like the shotgun approach, shoot and see if something hits.
I already take many of their ingredients.
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Most senescence is not replicative senescence.
It helps to have an idea as to why cells become senescent. What is your preferred hypothesis?
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There are myriad ways for cells to become senescent. Many of those ways also apply to plants.
How and why cells become senescent is way beyond my limited education so I don’t have a “preferred hypothesis”. I’ve read the papers on the many ways and accept that I have some, but not ultimate control of their creation. And I accept that as I age, they accumulate and continue to multiply beyond a beneficial level.
I accept the fact they exist, that they are both harmful and helpful and that there are ways to clear some of them, ways that are available to the average Joe/Josephine.
I also accept the fact that I will always have them regardless of what I do I just hope I don’t have too many as I age.
This method of senescent cells creation is quite pervasive.
I agree - I’m not a big fan of “kitchen sink” type supplement formulas, other than a good multi-vitamin
I feel that a supplement formula that is focused on doing one job well is more desirable and I can then pick and choose other interventions of interest.
Ours is entirely focused on helping the key ingredients be as effective as possible. Nine ingredients;
2 of the currently recognized natural senolytic polyphenol flavinoids
5 bio-availability enhancers for those polyphenols
1 digestive
1 synergistic compound that enhances the 2 polyphenols blood brain permeability
All at doses that are as close as we can get to the doses used in multiple studies.
My design philosophy stems from my experience in designing a patented medical device back in 1989 and another one (not patented) in 1995. Look for the weakness in the current “state of the art” and find ways to compensate for those weaknesses to provide a product that does what we say it does.
Back then we did achieve 4x 510k’s in 5 years of product dev, we had a busy dev team
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