DIY Rapamycin Toothpaste and Flossing Paste

I use my rapamycin toothpaste twice a day - morning and evening.

The evidence for rapamycin entering the bloodstream is negative - in the Transcutol-based skin cream they tested, and got no entry into the blood stream of the rapamycin.

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More good reasons to put emphasis on oral health, and perhaps rapamycin toothpaste. Amazingly, poor oral health is linked to decline in muscle strength:

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obviously it is impossible to to purchase Transcutol in Europe, has anybody been successful so far?

Have you tried all the different possible identifiers for transcutol in europe?

Transcutol has a number of different chemical names/identifiers. Here is a list:

  • 2-(2-Ethoxyethoxy)ethanol: Ethoxydiglycol, 3,6-dioxa-1-octanol,
  • DEGEE, diethylene glycol monoethyl ether,
  • Carbitol,
  • Carbitol Cellosolve,
  • Transcutol,
  • Dioxitol,
  • Polysolv DE,
  • Dowanal DE

Chemical Identifier: CAS Number 111-90-0

I have searched for it but haven’t been able to find it. I’ve experienced before that some other drugs/items are available OTC in the US, but require a prescription in (different parts of) Europe. If anyone had a different experience and was able to find transcutol in Europe, I’d love to hear about it also.

thank you for your quick reply,
I could find Dowanal in the EU, but it is reported to be 1-Methoxy-2-propanol., what
obviously is somehing different…?

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Yes - that is a different compound, as you can see from the different CAS number (see below).

It seems that there must be someone selling transcutol (it seems like a pretty benign liquid) somewhere in the EU.

Looking at this:

It does not appear to be restricted in the UK.

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Hmm…
when you try to order, this appears:

"* This product is a chemical and requires you to have an SLS credit account.

  • Please note that this is different to a website ordering account. Please contact us to arrange this for you."

Also UK unfortunately is no longer EU, so things anyway are difficult to order

Previous studies have demonstrated clear links between oral health and common diseases, such as cancer, cardiovascular disease, diabetes and Alzheimer’s disease. However, there have been few longitudinal studies identifying which bacteria occur in infected oral- and maxillofacial regions.

“Our results provide new insight into the diversity and prevalence of harmful microbes in oral infections,” says Professor Sällberg Chen. “The finding isn’t only of importance to dental medicine, it also helps us understand the role of dental infection in patients with underlying diseases. If a certain bacterium infects and causes damage in the mouth, it’s very likely that it can be harmful to tissues elsewhere in the body as the infection spreads.”

The research group has previously shown that the occurrence of oral bacteria in the pancreas reflects the severity of pancreatic tumors.

More information: Volkan Özenci et al, Clinical Microbial Identification of Severe Oral Infections by MALDI-TOF Mass Spectrometry in Stockholm County: An 11-Year (2010-2020) Epidemiological Investigation, Microbiology Spectrum (2022). DOI: 10.1128/spectrum.02487-22

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Really? “New light?” Below is from 2012, & even then not the first time, as more than 25 years ago I read about connections between dental issues & many degenerative diseases:

Bacteria from teeth / mouth enters the 60,000 + miles of blood vessels in the body, & impacts many organs.

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Newbie question, does chewing rapamycin taste awful? Or is this a good way to take them?

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You don’t want to chew rapamycin. All the rapamycin tablets you buy from pharma are specially constructed/coated to resist stomach acid, so that the tablet gets down to the intestine and disolves there, where the molecule is then taken up by your body. If you chew the tablet it destroys the coating and, I suspect, greatly reduce the bioavailability of the rapamycin.

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Ok, but crushing up one tablet for use in a diy mouthwash is ok?

Well, you need more than one tablet for the toothpaste or mouthwash…

And the goal with the toothpaste is penetration of the tissue and skin of the mouth (the tablet / rapamycin is not going through your stomach where it gets destroyed by stomach acid) - so yes, rapamycin tablets in your toothpaste or mouthwash is fine.

The goal of oral tablets of rapamycin is different; in this situation the goal is to get the rapamycin into your blood system (not just the cells and tissue of the mouth) so its important to maintain the protective barrier that is integrated into the tablets, so it doesn’t get destroyed in the stomach, and makes it into the intestine and ultimately into the blood.

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