A word of caution…I mixed my rapa toothpaste up and began using it. I was a bit overzealous, lol I not only brushed my teeth but also my gums, tongue and the roof of my mouth, pretty rigorously. I ended up making the recession WORSE on one tooth! Egad! I was always a rigorous brusher, which got me into this situation in the first place. I should have known better. So now i am all about easy does it. Good luck on your endeavor!
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What is the final final consensus regarding rapa being absorbed into the mucous membranes? Specifically the mouth. Some folks over on another chatroom say it definitely does get absorbed but i would love to hear opinions from folks here on that. I purchased some dental whitening trays and though i might try putting some rapa in the trays and sleeping with it. I grind my teeth in my sleep anyway and have used similar trays for that with no problem. Just wonder if it might be too much. Thanks!
Love your post! Can i ask if you brushed with rapa or took it orally? I bought some dental teeth whitening trays and thought i might put some of my rapa toothpaste in them and wear them when i sleep but i unsure if rapa is absorbed thru the gums or not. Didnt want to overdo it an dont know where to look for information about rapa absorption into mucous membranes…
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I think it would, just like skin for the rapamycin skin cream, especially if you are using transcutol or other solvent / reagent. I’ve never seen any reports of people trying it in the dental whitening trays before - and of course, no research on something like this is available. Perhaps try it and see how it goes?
Thanks so much for the reply! But here’s the rub…according to Dr. Mok (has videos on rapa on Youtube) they have done studies, i believe in the Drexel study, that showed that the rapa DID NOT absorb thru the skin of the participants in the study. That is why it is considered so safe for use with the teenagers that are using it for facial problems. Sorry I cant remember the name of what they have on their face but it is more than just acne. I read about it somewhere but cant find it again. In my other chat group it is believed that rapa does not absorb thru the skin BUT, no one knows, at least that i can find, if it absorbs thru the gums, which are not the same as skin.
Of all my groups this is the my go-to group as folks here seem pretty informed about rapa but man this one is a mystery…
Yes - it did not go through the skin into the blood stream, but it did get “into” the skin and thus the benefit (it it didn’t go into the skin how can it do anything). See here: Rapamycin May Slow Skin Aging (Drexel U. Study)
But most of us here are not trying to avoid rapamycin the bloodstream, we take it orally and topically.
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Ahhhh…of course, thank you for that clarification. So I wonder, if i not only brushed with my rapa toothpaste but also slept with the toothpaste in my dental trays at least a few nights a week, if it would be overkill. I feel like a risk taker, I am going to try it. Lol. Thank you again for such a quick reply and always helping! 
I had my dental hygenist measure my gum pockets before i started this so i will share my results when I go back to her.
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I only take rapamycin orally 6 mg once a week.
I also think Taurine… one teaspoon in the coffee each morning helped my teeth.
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anyone notice gum sensitivity using rapa toothpaste?
I’ve never had any issues. I can’t tell any difference compared to regular toothpaste. I’ve just finished a 3 month stint of using it twice a day, and will restart in another month or so.
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And now this, over the counter supplement for teeth health. Add to rapamycin tooth paste?
Diindolylmethane (DIM), also known as bisindole, that can cut down the biofilms responsible for plaque and cavities by 90%.
Natural Molecule Wipes Out 90% of Cavity-Causing Plaque
https://scitechdaily.com/natural-molecule-wipes-out-90-of-cavity-causing-plaque/
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KongKandy, Yes. With crowns and other dental work sensitivity to cold water starts after several weeks of use. I could speculate on the reason, but it would just be one person’s opinion. Using Sensodyne toothpaste solves the problem within two weeks. I’m now experimenting with Rapamycin toothpaste in the morning and regular toothpaste (or Sensodyne) at night.
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Just a quick note: make sure the toothpaste contains the ingredient “Novamin”. Sensodyne sells a bunch of different toothpastes, but only the one with that specific ingredient actually works for sensitivity.
And with regards to this whole thread: what is the proposed mechanism of action here? Gums recede with age, and how is inhibiting mTor in the mouth epithelium supposed to help with that? I don’t quite “get” it.
I think it’s a bandaid and only work while the ingredient is on the teeth, and unsolicited advice: stannous flouride toothpaste can be considered the best toothpaste in general according to different metrics and studies depending on your priorities:
It is like a bandaid, but the effect is quite long lasting, in my experience. I had horrible sensitive teeth, and a few days after using Novamin 2x per day, they were significantly less sensitive. After using it for several years now, I simply don’t have sensitive teeth any more and haven’t thought about it for a long time.
In terms of cavity prevention, tooth decay, tooth loss, I have absolutely no idea. But being able to have a cold drink without wincing in pain is a huge quality of life upgrade!
If DIM works as indicated in several studies it is definitely something to add to oral care routines. Plus it’s dirt cheap.
I’m going to add this to my mouth wash.
Also looks good for skin care…
https://journals.asm.org/doi/10.1128/spectrum.02056-21
In the present study, we investigated the antibacterial and antibiofilm activities of 20 indoles against C. acnes. Of the indoles tested, indole-3-carbinol at 0.1 mM significantly inhibited biofilm formation by C. acnes without affecting planktonic cell growth, and the anticancer drug 3,3′-diindolylmethane (DIM) at 0.1 mM (32 μg/mL) also significantly inhibited planktonic cell growth and biofilm formation by C. acnes, whereas the other indoles and indole itself were less effective. Also, DIM at 0.1 mM successfully inhibited multispecies biofilm formation by C. acnes, S. aureus, and C. albicans. Transcriptional analyses showed that DIM inhibited the expressions of several biofilm-related genes in C. acnes, and at 0.05 mM, DIM inhibited hyphal formation and cell aggregation by C. albicans. These results suggest that DIM and other indoles inhibit biofilm formation by C. acnes and have potential use for treating C. acnes associated diseases.
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I’ve been using DIM powder for a couple months now and it is quite amazing. I noticed the effect immediately. We empty a cap in our mouth and then brush with our usual toothpaste.
Interestingly it smells a bit like “gas” and that seems to be a result of the methane component of DIM (diindolylmethane)
My teeth feel like they have been cleaned by a dentist every day. I only use it in my morning routine and have skipped a few days to see how long this effect lasts. After continuous use for a week, it seems to last 3 to 4 days, then clean feeling starts to dissipate like a dental cleaning does.
We also started taking it in a cap in our daily supplement regimen. With the hope/speculation it may mitigate the other harmful biofilms in our body.
I think this oral biofilm is one of the reasons the hype about Hydroxyapatite seems to be over done. I’ve used hydroxy toothpaste in the past and did not see any visible effect. I’m now wondering if removing this biofilm will allow the Hydroxyapatite to be more effective in restoring tooth enamel. According the studies I’ve read the test tooth enamel is scraped clean before application to get the rebuilding effect. In dental offices they prep the teeth before hydroxy applications. Which makes a lot of sense to me.
I have DIM powder and Hydroxy powder in stock now and will be experimenting with a “paste”. My wife and I have a favorite toothpaste. I do not want to switch to another. My concept will be to make the DIM/HYA paste separate from any toothpaste so people can add this to their normal dental routine and keep their fav toothpaste.
Once I have the formula sorted I’ll post it here.
dim from cruciferous vegetables.pdf (313.4 KB)
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Why not use all three powders: Rapamycin, Metformin and Melatonin?
Personally it helped a lot with gum health.
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See this post and associated links: New Study Funded: Towards reversing periodontal disease using Rapamycin
especially this link: https://snapshot.org/#/s:vote.vitadao.eth/proposal/0x8464713774628fa0af6262478f7c1ecccb0a3272cc72f6324183f598e9f29007
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If you don’t mind sharing, what is your current recipe?