I live in a very high insolation area. I’ve been practicing sun avoidance since about age 20. Sunscreen, which I started using around age 30 makes an enormous difference. The formulations were not very good in the early 90s but I’ve been using very high UVA protection sunscreen since 2005, something that most people don’t bother with since it’s not available in the USA. I apply a lot and reapply frequently. I also use a wide-brimmed visor and sunglasses.
Topical rapamycin is also helping a lot.
I’ve also been using tretinoin for 47 years.
I think just about any other regular use topical is of negligible benefit compared to these.
I’m 60, live in a high insolation area, and my face and neck are like a baby’s bottom.
Maybe you can get away without sunscreen if you live in Tromsø and you never travel south. But people who do, and then spend two weeks a year in Greece, can do an enormous amount of damage to their skin.
You are saying that making it similar a commercially available preparation is not good, that this preparation’s approval by FDA and proven efficacy is irrelevant. But why? What is so “not good” about it? Do you have any relevant citations for why this medication is poorly formulated?
don’t even think about using sunscreen or any other cosmetic in general - such a waste of rapa. esp if using crushed tablets just use micellar water or make your own. different micellar waters are quite different . just use distilled water propylene or polyethylene glycol such as PEG400 and tween 20 or 80 at most at 5% and maybe ethanol or isopropanol at up to 8% and if u don’t mind spending the money maybe dmso at up to 10% or even Transcutol instead at maybe 5 to 10% depending upon how much money u willing to spend. Except for the last 2 the others are readily available and inexpensive well maybe except for PEG or non-denatured ethanol - easier to just use isopropanol although it is a little harsher - don’t really know if u want to use denatured alcohol. And if u want it thicker can add up to 0.5% xanthan gum for around $5 from walmart enough to last one about 500 years. That will work infinitely better than using it with sunscreen or most any other cosmetic esp for ones thicker than 30 wt. motor oil as the published expiriment showed. As u would expect the expiriment showed using it with most cosmetics showed no or negligible penetration. The main thing is u want to stay above but close to the Critical micelle concentration, CMC ,for the propylene or PEG and the tween 20 or 80.
that’s right it isn’t for most any if not practically all. have you even heard of critical micelle concentration, micelles, micellar ? suggest u do some reading on water insoluble substances.you may get some penetration but atleast 20 fold less than u should be getting. FDA cares about safety - doesn’t matter if its a worthless product. Not saying Hytfor is worthless but it has nothing to do with rapamycin.
As a matter of fact, I have. But also as a matter of fact, I have not encountered any reason to believe that topicals are ineffective if they do not including micelles. There are many ways to enhance penetration. Surfactants are one way, but by no means the only effective way.
now i have experience with that author who claimed the Terpineol worked better than did the dmso with lidocaine. I just believed him at first but now i really have doubts given his attitude. Unlike any other authors who were grateful for pointing out blatant or any errors he seemed to care less about blatant errors. So now i must say i have doubts about his findings.
there’s something wrong with that place or they don’t sell it anymore. i search transcutol and it says no have. Nowadays i can’t even find dmso at a reasonable price unless i have to personally go to some horse place in Florida and even that is not all that good of a deal.
Note: Transcutol has a number of different chemical names/identifiers. Here is a list:
2-(2-Ethoxyethoxy) ethanol:
Ethoxydiglycol,
3,6-dioxa-1-octanol,
DEGEE,
diethylene glycol monoethyl ether,
Carbitol,
Carbitol Cellosolve,
Transcutol,
Dioxitol,
Polysolv DE,
Dowanal DE
I don’t have time to study this whole post but am wondering who is getting the most miraculous results here? Where do I begin? I am currently dissolving sodium nitrate into an NMN facial liquid and adding a couple of drops of lemon juice. This is my home made recipe for promoting nitric oxide production on my skin. It works pretty good along with slugging at night with an aloe vera based Indian vaseline.
How do I start making my own Rapa topical? Can I also add MSM to it? I am ready to try anything that is getting good results. The eveness of my skin tone and the tone itself is excellent, but I have some deep lines and also protruding veins.
Who is the expert here who can offer me a recipe that is worth the time and effort
My last post was probably too general. I have found a source of methalyne blue and already have a bunch of stuff including hydralonic acid for topical use (powdered), mannitol, liquid NMN, MSM.
I am looking for a supplier of powdered Rapa. The Indian site above didn’t seem to have it listed as a product. Can I just crush tablets?
I don’t have a lot of time for the science atm but anyone willing to give instructions of how to make something they have found amazing would be great.
Okay from here in this post things will get a bit out there - but if you are game here is some of what I am playing with…
Lugols solution: For years I have every now and then taken it vaginally on a tampon. I read studies once that this method of delivery caused it to be taken directly into women’s breasts - which is where women store it. Taken this way it gets rid of lumpy breasts in about 15 minutes!
I then read recently that it has been discovered that the same organism that is our mitrochondria have been found outside of the human body living in iodine rich hot springs. This is pretty wild as like most of you might know mitochondria have different DNA to us - even though they are a part of our cells that we would not survive without.
Reading about what Methalyne Blue does in the mitochondria, made me think of Lugols which is similar in its super intense colour, and if mitochondria live in an iodine rich environment outside our body I figure they must like it! I also then remembered that Japanese women have such beautiful young looking skin, I wondered if it might be because they get so much more iodine in their diet to us?
All of this has led me to adding a drop or two of Lugols to a small spray bottle filled with micellar water and misting it on my skin (careful of clothes!) I am quite tan and so it doesn’t colour my skin at all.
I wonder if anyone else has tried this? It makes my skin feel instantly tighter.
Anyway I am open to instructions on what anyone wants to recommend! Thanks if you can be bothered!
Sure - its probably a little bit better (the filler of the tablet isn’t included in the final formulation), but its just a lot easier using the tablets because most of us have them already. And we know the rapamycin is likely of good quality because its gone through the Pharma quality control processes.
By comparison if you buy the pure rapamycin powder (eg. from a china middle man) you really have no idea of the quality / purity / contaminants unless you do a lab analysis on it, and getting a good lab analysis done on the rapamycin by an analytical chemistry lab is typically pretty expensive (e.g. $500 to $1,000), and even then you are not likely to find out any contaminants / other chemicals mixed in because that is hard to do if you don’t know what you’re looking for.
Of course - for a topical cream perhaps purity and contaminants are less important because you’re just applying it to your skin and if it causes a rash or something then just stop using it. Its not like you’re consuming it and concerned about invisible issues inside your body.
Thank you for this information.
Would powdered Rapamycin pills mixed in Aquaphor cream be a good way to make a topical cream in your opinion? What concentration is ideal? 0,1% Rapamycin for example would mean 396 mg of Rapamycin mixed in a standard 396 g Aquaphor Ointment cointainer and 0,01%, 39,6 mg of Rapamycin in 396 g Aphaphor, quite a large quantity.
Yes - I use something similar. But first I dissolve the rapamycin (I’ve used tablets, and I’ve used powder) in transcutol (as it is a very good way to increase absorption in the skin), and then after its well dissolved, I mix it in with a 396 gram container of Cereve cream, or cetaphil. Or Aquaphor, I’m sure its fine too. Yes - its a fair amount of rapamycin. You can use either tablets or powder (I am personally less concerned about the China-sourced rapamycin powder for topical applications as it does not penetrate systemically). People have mentioned sources of cheap rapamycin powder that they have used - see this post for example: Sirolimus Powder - 3rd party analysis
It would be expensive if you would order just a few month supply, but if someone were to order a 5 year supply then even with the cost of testing the purity it could come out a lot cheaper than buying pills. So it sounds like a reasonable thing to try for those that have access to lab testing.
