I did botox twice some 10 years ago for crows feet, but really did not like the results. It altered my face expression and I almost did not recognize my smile anymore. And yes I did not have crows feet, but other muscled compensated and had this really strange wrinkles below my cheeks.
Forehead and brow area is really difficult to inject properly for men, as muscles are relatively stronger and/or your brows can get a slight curve which feminizes the face. I would really not recommend botox.
But if you decide, try to get a really knowledgeable injector that injects lot of men and try âbabyâ botox first, to see if you like the result. You can always add more.
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Some more clarification on what you intend with the âsmoothie â you mention would be so much appreciated 
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Smoothie will take a wrinkle away. It flattens it. Itâs similar to ironing your shirt. Try it. Before you buy it, try to apply a piece of scotch on your wrinkle and see what happens in an hour.
This is how âsmoothieâ looks:
And this is the result of it:
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Smoothie is the trade mark ? Will definitely try; your pictures are incredible and you look so much younger ! 
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You can find all kinds of skin smoothies on Amazon. Different shapes for different areas.
Facial Smoothies LONG Wrinkle Remover Strips, 48 forehead anti wrinkle patches Amazon.com
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has anyone ever heard of using nmn topically - i guess not because of its low solubility at only 1.8mg/ml while NR is 58mg/ml or what about just niacin=nicotinic acid is vitamer of vit B3 soluble 18g/L or niacinamide= nicotinamide soluble at 17g/L . Ofcourse solubility is not the only or likely not the most important consideration. So now of these 4 : NR , NMN , niacinamide , or just niacin is the most suitable and in what conditions with what else and which is the cheapest per unit mass. I seem to recall out of these 4 only niacinamide is commonly listed. So where do u get the advantage or whatever of using NR instead ? What if injected at what concentration would they clog or not clog say a 30awg needle.
how long does the smoother or less wrinkles or whatever one may call it or the noticeable improvement last ?
it is likely better to massage it into your skin rather than only spray it and use a primer such as urea and or dmso and/or possibly alpha terpineol and sufactants, cosurfactoants, isopropanol and combinations etc.of course all diluted to a certain amount before applying the rapa ⌠gel, cream, serum or whatever and/or maybe
do a microneedling prior if u wish. All or some of those to make your skin much more receptive before applying expensive rapa with whatever. Though if one uses something made from crushing tablets it likely doesnât matter since that is likely not going to work in any case or at most very poorly compared to many other ways starting with rapa powder. Note on not comprimising skin structure as a possible advantage of Transcutol implied in a write up over dmso etc.
compromising the skin structure such as maybe dmso and urea is just what makes them favorable as penetration enhancers and of course it is not a permanent alteration.Temporarily changing skin structure, or however u want to put it , is desirable in this case and gives them advantages or desirable penetration properties over substances that do not âŚskin structure. Though not necessarily implying in general that they are or are not superior in some sense to Transcutol.
Thanks for this! I have never heard of this extract, but there is quite a bit of data out there. This appears to be the first cited source and I am going to look at the others. This paper reviews 75mg PO once daily in women with success for hyperpigmentation.
Nutritional strategies to benefit skin health are of growing importance. Current approaches mainly involve nutritional supplements containing antioxidants which were initially designed to protect human skin against ultraviolet radiation-induced damage. Within recent years, however, a growing number of studies suggests that the beneficial effects of these products clearly extend beyond photoprotection. In this review we take the nutritional supplement PycnogenolÂŽ, which is based on an extract prepared from French marine pine bark extract, as an example to illustrate this development. Accordingly, the existing data provide compelling evidence that PycnogenolÂŽ intake does not only provide photoprotection, but may be used to (i) reduce hyperpigmentation of human skin and (ii) improve skin barrier function and extracellular matrix homeostasis.
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Hereâs a recipe based on FDA approved Hyftor, a 0.2% gel
for 97 g/ 3.2 oz gel and modified from a recipe for eye gel on makingcosmetics.com
phase a
distilled water 46 g or 1.6 oz or about 3/4 cup
carbomer 940 0.15 g or about 1/16 tsp
phase b
triethanolamine (pH adjuster) 0.05 g/ 1-2 drops
phase c:
20 mg rapamycin powder
50 g 91% isopropanol (has density of about .8 g/ml)
phase d:
benzyl alchohol/DHA preservative 0.4g/9 drops
Sprinkle the carbomer into the water and let hydrate
for 5 minutes. mix well with hand mixer until dissolved.
Add phase b. pH should be between 6.5 and 7.
below 5 the gel will lose its viscosity.
Add phase c and mix well.
Add phase d and mix again.
It will be drying but easier to spread than a liquid spray.
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IF U are talking about crushed tablets which u are, transcutol likely does not dissolve rapamycin at all or very very little as that crushed substance is very very little of rapa and even at that does not get to the rapa other than possibly the very small amount which is on or very near the surface of those macroscopic particles. you need to extract the rapa out of that whatever which is not easy to do and u donât do that with transcutol. Extraction of the rapa is likely beyond the means of layman and also of the compounding pharmacy also and then after extraction u have other processes to do
For my part, I use the contents of capsules prepared by a compounding pharmacy. The transcutol certainly appears to fully dissolve the rapamycin powder and whatever added fillers the powder has.
Would this kind of topical application really need any more?
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@Jonas or @Alpha ââŚall u needâ What are u nuts ? So that means it is good penetration or any significant at all penetration of rapa into the skin ?will say for sure u need a lot different than that. You have not done any analysis nor tests nor microscopic analyses. Do u even know what micelle , micellar , surfactant, cosurfactant and emulsions means ? By âhappenstanceâ or
pot luck you may get some penetration but not nearly as good as starting with rapa powder and doing it other ways of which there are many on the internet -yea many are too difficult for the layman but many are not and most are like 1/100 the price. To be more to the point that ââŚall you needâŚâ statement is ridiculous in general. The literature is full of such that there was no detectable measured penetration or significantly too little of the active or desired component into the skin of which some were even commercially sold products. And note especially just because it is a commercially sold product does NOT mean it is formulated in the best or anywhere near the best way. For example EMLA cream which as most anyone has tried is about totally useless !
100 mg rapamycin powder? thatâs a lot and very expensive
I fixed some typos. This reply will not be saved unless it has 20 characters.
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so in summary, what is the solution?
solution to what ? You donât use rapamune period. if u want to make topical u start off with rapa powder and how to make topical in nearly infinite number of ways and also how to make oral or injection is also all over the internet articles and u pay about 1/100 of the price as one does getting rapamune.To me one has to be insane to pay those prices doing it any other way !! really dumb or money is no object to them. And the topical is superior.and so is the oral if u use TPGS(synthetic water soluble form vit E) CAS 9002-96-4 which is around $130 per gram and other more common unexpensive items. Yes expensive for TGPS but no need much of it and follow all the articles on internet which also show it is superior to rapamune and still much cheaper than buying rapamune. There are also many other ways of making topical or oral without using that expensive TPGS and still ok and especially for injecrion which is most efficient.
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While I donât agree with Dan on many things (I think he takes far, far too many risks with his body), but rapamycin powder can be very cheap when purchased from China, he is correct on that account.
However, you never know what other contaminants are in the powder, and what purity the powder is, unless you get a good analytical chemistry lab to test it, and that typically costs about $700 to $1,000 in my checking. So for most people, who want to know they have a quality product, the cheap rapamycin powder from China quickly becomes the most expensive option if you want testing and validation of the quality.
Now, in the original rapamycin skin cream paper there was not any detectable rapamycin that made its way through the skin to the blood system so it would seem to suggest that using low quality rapamycin powder from China might not actually be much of a risk systemically because its not getting into your body, though it may be that other contaminants in the powder cause skin irritation or other issues of a topical nature. So - if anyone were to use China-source rapamycin for powder, it seems that the topical application would be the lowest risk approach.
At the same time unlike Dan, I donât think there are any issues with regard to using the crushed tablets of rapamycin in a topical formulation. This is what has been done in a number of Clinical Trials Iâve seen Facial Angiofibromas of Tuberous Sclerosis Treated with Topical Sirolimus in an Indian Patient - PMC .
I donât believe there has been any evidence shown that suggests the filler in the tablets in anyway impacts absorption or efficacy of the topical sirolimus / rapamycin.
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At $950/20g and likely u could find even cheaper 100mg is $4.75 . I would not call $4.75 that expensive would you or even if you bought a smaller quantity and had to pay twice that much.
Are u crazy. Tretinoin is far better . Staying out of the sun and applying tretinoin and/or a lot of other things are better than sunscreen . What good does applying sunscreen do if any if one avoids the sun ?