Hi Arhu,
There’s a study in Nature that reports a significant lowering of blood pressure from oral nattokinase supplementation. Effects of Nattokinase on Blood Pressure: A Randomized, Controlled Trial | Hypertension Research. Wouldn’t this suggest that the nattokinase is not broken down in the stomach, or at least that there is some mechanism for absorption?
Thanks
Joel
FWIW, I saw this today:
vaccination against COVID-19 is associated with fewer heart attacks, strokes, and other cardiovascular issues among people who were infected with SARS-CoV-2, the virus that causes COVID-19.
Recent pilot studies on the pharmacokinetics of NK have not provided an answer to the question of how NK is absorbed into the body.16,60 In fact, the pharmacokinetic data are rather inconsistent and mismatched with pharmacodynamic activities. Ero et al60 claimed that NK was measured directly in their study with a peak concentration at 13.3 hours after oral administration, whereas the thrombolytic activity of NK, measured in another study, was shown to peak 2 to 4 hours after oral dosing.16 These data imply that measurements of NK in the published studies may not be those of the intact NK molecule. Although it has been assumed that NK is stable in the GI tract19,28, it is important to address the key question of the mechanism of NK absorption into the body, with more convincing direct evidence. In fact, several groups have pointed out that the molecular size of NK is considered to be generally too large for oral absorption through the GI tract.19 It is recognised that NK may be susceptible to chemical oxidation and subsequent inactivation, or denaturation, in the GI tract.64 Thus, further studies are required to fully understand the pharmacokinetics of NK.
This is from the study Joseph put elsewhere:
Bizarre that we don’t know this yet. No money to study the cheap stuff that works.
Natto - Delicious for those people who have a taste for it - which is a distinct minority of people who aren’t Japanese. Most of the rest of us think it’s a pretty stinky mess (albeit a very nutritious one).
A twitter thread worth reading for anybody interested in Nattokinase, particularly with respect to use in (Long) COVID: https://twitter.com/organichemusic/status/1572885502457704453
TL;DR? (1) Nattokinase probably needs to be enteric coated to survive the trip through the stomach (consider Doctor’s Best brand “Natto-Serra”, which is enteric coated - unlike Doctor’s Best brand Nattokinase), and (2) you need a substantially higher dose (like around 10,000 FU daily) for decent results.
Enteric coating is really hard to do, and those type of capsules don’t work well. The owner of nootropicsdepot has talked about this for other supplements. It probably has to be in tablet form with a relatively expensive polymer coating of some sort.
This article says Lumbrokinase is much more powerful:
Or you could just eat the worms.
You need the Hepatitis/HIV drug to get rid of long Covid. If you can find a vendor that’s not a scammer, it’s called
Hepcinat In India. It America it costs about the same as a new truck. That drug cuts the chain, so it can’t continue to replicate in your body. It’s pretty safe as well.
Salvia miltiorrhiza Is great too. Not a cure, but a great natural root good for blood circulation and the heart. Some pretty impressive articles online.