Wait…Levine Phenoage is suppose to be a leading epigenetic aging clock (used by a lot of members it appears), implicitly associated with aging rate, and thus all cause mortality? It boasts the use of only a single overt inflammation marker…CRP.
“Irvin et al. (15) found that ‘extrinsic AgeAccel’, related to the first generation Hannum epigenetic age measure (16), was associated with interleukin-6 (IL-6), CRP and tumour necrosis factor-alpha (TNF-α), albeit with modest effect sizes”
And yet, inflammation is an independent predictor, no surprise here.
Clearly, these “clocks” might be associated with “some” biological aging rate…but predicting your true intrinsic aging rate and all cause mortality, I’d say less so.
So, overlay a deeper set of inflammation markers in your longevity tracking stack?
In my last lab panel, I ordered TNalpha and IL-6, in addition to CRP.
Association between inflammatory biomarkers and all-cause, cardiovascular and cancer-related
mortality
Conclusion
We found no evidence that AGP is a stronger prognostic marker ofmortality than the widely used inflammatory markers IL-6 and CRP. As in previous studies, elevated AGP was associated with 5-year mortality. However, even with this length of follow-up, it did not do better than IL-6 in predicting mortality. Our analyses of all-cause,cardiovascular and cancer-related mortality suggest that IL-6 maybe a better prognostic marker for all of these outcomes, in both theshort and the LONG term.
Your own screenshot chart indicates to me that I will be sticking with just the CRP marker
At Quest, the IL6 test is three times the cost, but it does not appear to be a three times better marker than CRP.
I am I wrong in interpreting your chart?
Huh. Thanks for these. The first is from a supplement company, but the second is enough to make me shift to “confused” as a view on curcumin and testosterone.
It is one of MANY ways to age, but you can massively increase glucocorticoid levels, which accelerate aging AND reduce inflammation (tho high GC doses also increase SOME cytokines)
Cost per polyphenol concentration is more appropriate than cost per tablespoon.
Super high polyphenol level might cost a lot but one doesn’t have to consume anywhere near as much to get the same benefit.
A spoonful of sugar helps the polyphenols go down.
If the research show that grape polyphenols reduce inflammation and sarcopenia, that’s all the reason I need to eat these delicious little bags of sugar.
Especially when you coat them in water and freeze them. Nothing better on a hot summer day…
Yeh, I don’t know about the whole issue of the tradeoffs of the nutritional benefits of grapes, vs. the downside of the blood glucose spikes caused by the grapes. If you’re on metformin, SGLT2 inhibitors (cangliflozin) or perhaps acarbose, maybe the issue goes away … Its very hard to parse all the data, given the imperfect world of nutritional research studies.
There doesn’t seem to be a test for "fake"ness. They tested for the key variables that define the quality. Haven’t read the full article, but I didn’t see any “fake” judgements.
