I would like to start a new thread that examines interventions other than drugs and supplements.
This would include red light therapy, radio wave therapy, etc.
This is a very interesting video. My only real critique is that I wish he was from a more prestigious university. He seems well-spoken and seems to make valid case for further studies of his device.
Might work.
I like the cap idea, but have an inclination to use it with PEMF coils.
Lots of work available on PEMF.
See…
Conclusion
Poor regulation of inflammatory/immune function can allow acute-phase inflammatory response to become chronic, initiating disease and inhibiting tissue regeneration. Current theories of damage-associated molecules released by injured/infected cells or secreted by innate immune cells generate danger signals, activating the immune response. These signaling mechanisms are important to the subsequent activation of homeostatic mechanisms that control the immune response in pro- and anti-inflammatory reactions that allow for therapeutic treatments.9 In this review, we described the effects of PEMF on inflammatory/immune regulators and transcription factors relevant to the activation of danger signals and innate immune cells. Achieving homeostasis in the face of acute inflammatory/immune challenges in the human body involves maintaining a balance of highly complex biochemical and cellular interactions, such as cytokine expression and signal transduction. When this delicate balance is upset, acute inflammatory and immune responses designed to quickly eliminate a transient threat become chronic, and inflammatory and/or autoimmune disease sets in. The importance of maintaining healthy cytokine expression during this impactful time cannot be overstated. Our feasibility study shows that PEMF has the potential to regulate this very delicate balance. More investigative research is needed to discover therapies to regulate signaling molecules involved in inflammation and tissue regeneration. We propose PEMF as such a therapy and performed a proof-of-concept study using MSCs, MΦ, and C2C12 cells, exposing them to PEMF to investigate its effect on expression of inflammatory molecules after insult. Results show that the immunomodulatory effect of this therapy has the potential to decrease the production of proinflammatory secretion, while stabilizing or increasing anti-inflammatory cytokine production, and NF-κB expression during activated response. By modulating the expression of various signaling cascades and cellular information processing networks to restore them to homeostatic (healthy) production levels, PEMF is showing promise as a treatment for inflammatory regulation to be used to promote tissue regeneration.
The paper also has extensive references.
Also:
Works on brains.
Relatively inexpensive. No contraindications. Available now.
I think Arendash’s websites and “marketing” materials do him a disservice. They look cheap. I lead institutional investment for my firm, and my team would dismiss him and his work on these presentations.
That said, this stuff matters, so one can find actual journal published papers. See:
Joseph_Lavelle - Did a long interview with Bob Dennis of MicroPulse. That interview, the links I posted earlier, and that cap in the opening post inspired me.
I’ve just order a pair of lightweight helmet liners (simple stretchy close fitting caps) to sew together with 4 PEMF coils between the layers.
I plan to use it with my basic MicroPulse ICES device.
I’ve used PEMF on my brain in the past and it (pure subject assessment) just clears things. More focus used during work. Easier to sleep used before bed.
I suspect it would have similar (and perhaps better) effects as Transcranial Electromagnetic treatment.
I’ve gotten more interested in this as I have friend now in his early 80s that has become concerned about cognitive loss. Brilliant guy. One of those brains one wants available for the good it can do the world.
If I have some success (hopefully beyond the subjective) with my PEMF cap I’ll make him one.
Any thoughts on how and what to measure?
"I have friend now in his early 80s that has become concerned about cognitive loss’
Look at Biden and Trump—everyone in their 80s worries about cognitive loss.
I am very interested in your experiments, please keep us posted.
It would be great if you could do any or all of the following tests before and after PEMF!
That way, we would have a comparison to Red light therapy / / transcranial photobiomodulation (tPBM) / transcranial infrared laser simulation TILS, i.e. low-power and high-fluence light from lasers or light-emitting diodes in the red to near-infrared range (620 to 1100 nm) onto the cerebral cortex.
These tests show improvements in various cognitive aspects from RLT/tPBM/TILS therapy vs placebo all in healthy adults of various ages (except nr 5 below that was without placebo and in adults with self-reported emerging memory complaints).
1 Sustained-attention psychomotor vigilance task (PVT) testing reaction time, delayed match-to-sample (DMS) memory task testing working memory and Positive and Negative Affect Schedule (PANAS-X),
2 The Wisconsin card sorting test for executive function
3 Accuracy rate and response time in 1- and 3-back tasks
4 Flanker and category fluency test
5 Resting-state EEG alpha, beta and gamma power (+PVT/DMS)
1 PVT, DMS and PANAS-X
Light that intersects with the absorption spectrum of cytochrome oxidase was applied to the forehead of healthy volunteers using the laser diode CG-5000, which maximizes tissue penetration and has been used in humans for other indications. We tested whether low-level laser stimulation produces beneficial effects on frontal cortex measures of attention, memory and mood.
Reaction time in a sustained-attention psychomotor vigilance task (PVT) was significantly improved in the treated (n=20) vs. placebo control (n=20) groups, especially in high novelty-seeking subjects. Performance in a delayed match-to-sample (DMS) memory task showed also a significant improvement in treated vs. control groups as measured by memory retrieval latency and number of correct trials. The Positive and Negative Affect Schedule (PANAS-X), which tracks self-reported positive and negative affective (emotional) states over time, was administered immediately before treatment and 2 weeks after treatment. The PANAS showed that while participants generally reported more positive affective states than negative, overall affect improved significantly in the treated group due to more sustained positive emotional states as compared to the placebo control group
2 Wisconsin card sorting test.
Improving executive function using transcranial infrared laser stimulation - PMC (nih.gov)
Specifically, we ask whether transcranial laser stimulation enhances performance in the Wisconsin Card Sorting Task (WCST) that is considered the gold-standard of executive function and is compromised in normal aging and a number of neuropsychological disorders. We used a laser of a specific wavelength (1064 nm) that photostimulates cytochrome oxidase—the enzyme catalyzing oxygen consumption for metabolic energy production. Increased cytochrome oxidase activity is considered the primary mechanism of action of this intervention. Participants who received laser treatment made fewer errors and showed improved set-shifting ability relative to placebo controls.
3 Accuracy rate and response time in 1- and 3-back tasks
61 healthy older adults were recruited to participate in a longitudinal study involving an experimental baseline, seven days of tPBM treatment (12 min daily, 1064-nm laser, 250 mW/cm2) in the left dorsolateral prefrontal cortex and three weeks of follow-ups.
Repeated and single tPBM significantly improved accuracy rate in 1- and 3-back tasks and decreased response time in 3-back compared to the baseline. Moreover, the repeated tPBM resulted in a significantly higher improvement in accuracy rate than the single tPBM. These improvements in accuracy rate and response time lasted at least three weeks following repeated tPBM. In contrast, the control group showed no significant improvement in behavioral performance.
Recent studies have shown that a few minutes of tPBM over the frontal cortex could significantly improve cognitive outcomes, such as memory7 and executive function9 in young adults.
4 Flanker and category fluency test
Photobiomodulation Improves the Frontal Cognitive Function of Older Adults - PMC (nih.gov)
Significant group (experimental, control) × time (pre-PBM, post-PBM) interactions were found for the flanker and category fluency test scores. Specifically, only the older adults who received real PBM exhibited significant improvements in their action selection, inhibition ability, and mental flexibility after vs. before PBM.
The PBM device consisted of three separate light-emitting diode cluster heads (633 nm and 870 nm), which were applied to both sides of the forehead and posterior midline,
5 PVT DMS (same as nr 3) also resting-state EEG alpha, beta and gamma power,
Beneficial neurocognitive effects of transcranial laser in older adults - PMC (nih.gov)
Note: This study was without placebo, however the functional neuroimaging study included a comparison control group without laser treatment
Transcranial infrared laser stimulation (TILS) at 1064 nm, 250 mW/cm2 5 weekly session 8 minutes each.
We investigated the cognitive effects of TILS in older adults (ages 49–90, n=12) using prefrontal cortex measures of attention (psychomotor vigilance task, PVT) and memory (delayed match-to-sample, DMS), carotid artery intima-media thickness (measured by ultrasound), and evaluated the potential neural mechanisms mediating the cognitive effects of TILS using exploratory brain studies of electroencephalography (EEG, n=6) and functional magnetic resonance imaging (fMRI, n=6). Cognitive performance, age and carotid artery intima-media thickness were highly correlated, but all participants improved in all cognitive measures after TILS
Comparisons of mean cognitive scores all showed improvements, significant for PVT reaction time (p < 0.001), PVT lapses (p < 0.001), and DMS correct responses (p < 0.05). The neural studies also showed for the first time that TILS increases resting-state EEG alpha, beta and gamma power, and promotes more efficient prefrontal BOLD-fMRI response. Importantly, no adverse effects were found.
As predicted, cognitive improvements as measured by the DMS and PVT tasks were larger in the older patients with higher IMT values than the younger participants
TRFT, very interesting, should be followed. Unfortunately it´s not available and won´t be for some time until FDA clearance…
desertshores, I recall you saying red light therapy improved your crossword puzzles, or something like that. Was there any other cognitive benefit you noticed? I just linked a number of RCT trials indicating various cognitive benefits on this thread.
I don’t readily have access to a battery of such tests.
Personally, I don’t have perceptible subjective evidence or concern about cognitive decline.
I don’t have genetic markers for it.
And I work in a demanding analytic field.
I have three key interests around this:
Reducing systemic inflammation - some PEMF studies on traumatic brain injuries showed promise of this (not just in the brain but systemically).
Optimizing cognitive performance - brains are the only thing the world has that solves problems. Better brains. Better solutions.
Checking if I experience any issues that would disqualify my friend using it.
N-1 biohacking but I think reasonable.
I wasn’t. implying you could have any cognitive deficit! I am thinking about optimizing cognition, for which one or more of those markers could be useful for assessing improvements.
I didn’t mean to imply that you implied 
Also, I very much concur with your interest in optimizing cognition.
This might be relevant given the topic of the thread (even if @desertshores already is aware of it himself)
Yes, I am experimenting with this.
I currently use a red light helmet, that can change the frequency and duty cycle, along with full-body red light therapy.
I have also used various forms of 40z audio therapy including the MIT Alzheimers plaque removal protocol and other various forms of 40 Hz audio brain entrainment.
Subjectively, I have felt nothing.
Though I do like lying under the full-body red light therapy device.
It makes me feel warm and toasty like lying on a beach in the sunshine. 
Your experience from PEMF clearing things and yielding more focus in work is intriguing, although I can’t find any study about it on cognition in healthy humans. Perhaps because it is mostly used for pain relief and injury recovery, as per the survey you posted.
If you know of any other (anecdotal) evidence on cognition in healthy humans, please let me know. It could help motivating me add it to red light therapy; that survey showed 45 % of PEMF users also using RLT.
Auditory, visual and manual therapy.
Sound:
Light:
Manual Therapy:
Clearance of brain waste was mentioned in this thread via cervical lymphatic pathways:
As I mentioned there, this could be achieved by a physical therapist trained in manual lymphatic drainage or even by a properly educated patient themselves. I believe a combination of all three would be complimentary and effective in maintaining brain health.
