Dermo-electroporation for Aging Skin Health and Rejuvenation

I’m confused - this DEP is not the same DEP (dermo electroporation device) that was discussed earlier? Or is it?

All the same. I’m just sharing photos of the one I received and have started using. It’s the Chinese knock-off of the Italian Mattioli Engineering DEP product.

The quality of the build seems pretty good from initial inspection. We’ll see how it works over the coming weeks, and I’ll report how it goes.

If it’s the same are there other parts to it that you did not include in pictures?

I took all the parts from what you see in these photos: Dermo-electroporation for Aging Skin Health and Rejuvenation - #43 by RapAdmin

and put them together (but in this post, I’m just showing the hand-held section that plugs into the big oval “base” of the device.

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Alibaba has a video of it:

Yes - that looks like the same one I have.

It looks like generation 3 DEP (which I’m considering) doesn’t have any attachments (like a syringe). What generation is the one you received? Trying to figure out the difference. Is there any advantage of having a syringe instead of applying serums directly to skin?

The seller sent the following brief description: DEP Superconducting Water Light is a faster, deeper-penetrating alternative to traditional iontophoresis, eliminating the pain, inflammation, and risks of pigmentation. It addresses the issue of cosmetic-grade products being used for injections in cosmetic procedures, and the prohibition of medical instruments from being used in cosmetic procedures. DEP’s high-intensity electroporation technology enhances cell membrane permeability, instantly infusing various cellular nutrients.

The seller also told me that an instruction manual will be included.

Have you already tried your DEP unit on your neck? How did you like it?

I have no idea what generation my device is (or if there are even generations); or if there are indeed any differences or if they are just different marketing efforts to distinguish themselves from competitors. There seem to be a huge number of varieties of DEP devices on Alibaba and other sources. Given the proliferation of these devices, and the lack of any independent high quality evaluations of these devices, it’s probably a crap shoot in terms of what you get. If a company is claiming they are “generation 3” of the device, then the natural question is what is different and how are those differences going to be meaningful benefits for you?

I’ve only tried the device once. I like the integrated syringe control because it allows one-handed operation, and it directs the flow of the liquid directly into the area of the conductive areas of the device. It also seems like it could be beneficial (the one-handed operation) because you can then lie down and deliver the liquid on your skin when its horizontal (and therefore not so likely to run down your face or neck and out of the area of interest). And the arrow button works well… I understand now how the arrows work, the back arrow is to reset the small platform that pushes the plunger of the syringe, so after using it you reset it back to the starting point, reload the syringe, put it back in the device, and then the other arrow slowly compresses the syringe. It works well for slowly controlling the flow of liquid to the front of the device when you want it.

But again, there seem to be many different iterations on these devices and it’s very hard to tell which would be “better”. Here are a few different variations that I found after a quick search. They are all called “DEP” devices, but without any independent 3rd party analysis it’s really hard to be confident that any of them do what they claim they do. I’m still very unsure of their efficacy. If I were you, I’d wait until more people give their judgement on these current products we are using. After a few months of use, perhaps we can give more feedback on effectiveness of the ones we have. Perhaps we are as positive as Medaura or perhaps not.

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@RapAdmin you are supposed to put the plunger of the syringe inside that applicator tube and screw it sideways. That done, the < button pushes foward; the > retracts — or maybe vice versa. The middle L/H button initiates an automatic sequence of forward pushes at set reasonable intervals. The little tube attached to the disposable membrane goes into the opening of the syringe so that when the liquid is dispensed from the syringe via these buttons pushing the plunger, it can get delivered via that membrane covering the head of the appliance.

But… all of this is nonsense for me in practice because it gets in the way. It’s far more natural to completely skip these steps and in fact skip the disposable membrane because you don’t gain anything practically by having the liquid pushed through at these exact mini dosages. What I do is I use a syringe with my left hand to squirt a bit of liquid on a part of my face, and I use the DEP probe with my right hand to rub it in (I’m right handed.)

The point of the membranes is to provide a sterile environment if you’re using it on multiple people, say if you’re a provider with clients. The idea is to not have the electrode head touch many people’s skin and potentially pick up pathogens or whatnot (which shouldn’t even be a concern if you use a basic hygiene protocol). If you’re only using it on yourself and maybe your partner, skip the disposable membrane + tube, skip the dosage applicator, as it’s a bit awkward and cumbersome to use well on oneself (I can imagine it being much easier to use on a third party though) and just do it straight up. It’s very simple. Then clean the probe when you’re done with a gauze soaked in alcohol or whatever the manufacturer recommends.

Does it make sense? Of course you’re free to use it the other way but you don’t gain anything and then need to keep buying disposable parts. Besides the application takes longer. I tried it that way a couple of times then ditched it in favor of the streamlined protocol I detailed earlier.

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@RapAdmin watch this video to see how he does it. His model of the equipment doesn’t even have the bulky applicator appendage and he doesn’t need it. I apply my hyper dilute radiesse exactly as you see him do on the video. Nothing is lost in terms of efficacy. Doesn’t matter if my finger pushes out uneven amounts of liquid. It takes time for it to be properly absorbed, it takes many many passes of the DEP probe. His video is sped up and I don’t even think he covers the whole process. Expect to give your face a good half hour of rubbing around to get 70-80% or more of a ~5 ml concoction absorbed. The rate limiting part is not the pace at which liquid is pushed out of the syringe, but the pace at which you’re rubbing it in with the probe / electrode. Does that make sense?

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This stage with attached syringe was eliminated in DEP generation 3 as I understand.

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Not yet. The machine is arriving today. Will try to do it today with HA just to see how it works. Will report back.

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Was thinking of trying microneedling with Botox (aka micro-infusion) across the whole face for that less-oily, shrieked pores, glass-skin look. My guess is that a few units of Botox (20 units) mixed into an HA serum and infused with DEP could work just the same with less pain or redness. I will try this!

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Let us know how that works! I don’t think the Botox would give glass skin, it just paralyzes muscles. But I’ve never done it and maybe am missing out. To me NCFT 135 HA via DEP is what gives the closest thing to glass skin. I have the knockoff version and am thinking of buying the original to see if it’s even better.

I bet it was as it’s a very bulky and useless appendage.

What dilution ratio do you use for this type of application of radiesse? I’m assuming you use saline water and add and mix it yourself.

I use 1:2 and I used saline at first but ended up switching to NCFT 135 HA. Recall upthread ChatGPT told you to not do that but it personally works great for me. You want to keep a low dilution ratio as it’s still a challenge to get liquid across the skin even with DEP. It’s not as easy as an injection. So if the overall volume is lower, the process is less of a PITA and you get a greater % of that volume be the hydroxyapatite. Yes I mix it myself very easily with a luer lock. Look up videos of how to use a luer lock. It’s super easy and in fact satisfying. Also from the webinars I listened to with some Radiesse pioneers, 1:2 dilution ratio seems to be the best at stimulating elastin production.

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How much liquid (ml) do you use for how much surface area?

I have heard from a friend that if one has a certain type of crepiness in their chin, they get it botoxed and it makes it better.

This is not for wrinkles but a certain effect that pulling causes. Having said this, I think it just makes it more ‘normal’ and not glass skin.

Also, because it’s so affordable, you all are contagious and making me curious about the DEP machine

I know some devices can lead to fat loss in the face. Has anyone looked into that potential side effect with this specific device?

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