Dr Ward Dean of FL was pitching deprenyl. Dean really hasn’t been active with publishing, recent work. And any other orgs more recent human studies prob should be given preference. But here’s Deans advocation:
DEPRENYL- DOSAGES FOR LIFE EXTENSION PURPOSES
As stated previously, Professor Knoll is a man who ‘practises what he preaches’ and reportedly takes two 5mg Deprenyl tablets per week. We (Dean, Fowkes and Morgenthaler) recommend the following age adjusted titrated dosage schedule in our book, Smart Drugs 2.
30-35 1mg twice a week
35-40 1mg every other day
40-45 1mg every day
45-50 2mg every day
50-55 3mg every day
55-60 4mg every day
60-65 5mg every day
65-70 6mg every day
70-75 8mg every day
75-80 9mg every day
80 plus 10mg every day
Kitani and his colleagues (1996) found that the optimum dosage of Deprenyl, (which caused the greatest upregulation [increase] of antioxidant enzymes [SOD and CAT] in the brain in long-term studies) decreased by a factor of 5 (or 10). This was compared with the optimal dose in relatively short-term studies (3 weeks).
Unfortunately, by the time the results were calculated which showed the greater efficacy of reduced dosages of Deprenyl in long-term studies, Kitani’s group had already nearly completed another study using the much higher dose calculated from the short-term studies.
Contrary to the researcher’s expectations, the Deprenyl treated animals (given the high dose of Deprenyl based on the short-term studies), lived shorter lives than did the controls!
Kitani’s group is now repeating the study using the much lower Deprenyl dose that was determined to be most effective from the long-term studies.
Their work in progress appears to confirm that this lower dosage will result in life extension benefits for the Deprenyl treated animals.
Consequently, in view of the results of Kitani and colleagues, I recommend that my life extension patients consider the recommended dosages above as ‘starting dosages,’ and that they consider reducing their dosages somewhat after several months.
Kitani also concluded that ‘the proper choice of the dosage in long term experiments appears to be the key factor.’
DEPRENYL- RECOMMENDED FORMS
Deprenyl hydrochloride (Selegiline, Jumex etc) is the prescription form that is most widely prescribed by the orthodox physicians.
Liquid Deprenyl Citrate (LDC) is Selegiline, which is considered to be superior. This form is generally recognised as the most pure and potent form of Deprenyl available. It also allows precise titration for anti-aging purposes, as each ml drop in the bottle is equivalent to 1mg deprenyl citrate.