Deprenyl - Anti-Aging Drug Proven Effective in Dogs

I use for meds other than rapamycin. They also have some pet meds.

After you order from there you take your order number and verify it by online chat. And they usually ship out quickly.

Deprenyl as an MAOI may have serious interactions with some other meds like antidepressants. Checking drug interactions is important.

Aside from trazodone, they also have Valdoxan (agomelatine) which some people use for sleep.


According to Wikipedia it comes with a depression and suicide risk warning…doesn’t look like it would work in humans like it does in dogs as dogs can’t commit suicide


Its used as an anti-depressant, and all anti-depressant medications have that warning I think.

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I’d still stay away from it, it’s registered as an MAO-B inhibitor and apparently it also interacts with a whole host of other complexes including probably mtor, so it has a lot of side effects whereas rapamycin just interacts with mtorc1

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This is something I will not experiment with in high doses (or any dose). As an anti-depressant it works in low doses, and I don’t want to take a chance with messing up my brain chemicals with high doses (or any dose). And, even if you did try it would it be difficult to stop taking it afterwards? I don’t plan to take that chance. Do your research on this one.


“According to Wikipedia it comes with a depression and suicide risk warning”

As does almost every anti-depressant on the market.

As I am old and have no particular obligations other than to live longer, I am willing to take more chances and be willing to be the “canary in the coal mine” so to speak.
I don’t recommend anything I am doing to anyone else, especially younger people.

To paraphrase Michael Lustgarten Ph.D:
Live forever or die trying.

Maybe Elon musk will be able to upload my brain before I die? :grin:


“Maybe Elon musk will be able to upload my brain before I die?”

Well, you never know. Many people believe the Apocalypse and WW III are about to happen. So maybe all our efforts will be wasted.

Deprenyl was one of the first drugs I tried some years ago for anti-aging. I opted for the Emsam 6 mg patch for about a month. The only difference I noticed was that it shortened my sleep cycle. I stopped after that. I may try a lower dose pill in the morning instead.


Just familiar with the nootropic applications that seem to wane away. Most physicians have been warned repeatedly about MOA inhibitors due to the multitude of interactions. Psychiatrists would be our best resource for its risk to benefit value.


I hate contributing hear-say, without URLs backing up what I’m reporting!! :frowning: But…

I’ve been taking selgene/deprenyl for 10yr. Like my rapa experience no discernable benefits. But my blood work looks great and can work like a 40 yr old. LOL not scientific for sure.

The “father” of the deprenyl research (??) said he originally started on 5mg/day 2 days, then 3 off. Seems deprenyl has a dropping off of its benefits over time so need rest periods. Also like LDN benefits from a few weeks to a month off period. TBD… Then the last i heard from him (?? dont remember where, but a few yrs ago) he said personally he was taking 1mg / day continuously. This is a human body sized dose. mg/kg???

Now, like rapa, optimal dossing sched may have been updated??? But it would be my guess, that 10mg/day/no rest periods for a typical human would not be optimal, but saying its my guess.

I was wondering when deprenyl was going to surface in antiaging news. Also when LDN (low dose naltrexone)) has a role too. So much to piece together!

Best to all, curt


I hate thinking about such scenarios!!! For many years I packed raw carrots in my bag lunch. Every month or so I would have a serous choking event with stuck carrot chunks. As my life flashed in front of my eyes, I kept thinking how stupid would it be to die from “health protocols”!!! :frowning: ;( :frowning:

Now my (on the war path with me) Functional medicine Dr figured out a trick to cut my kitchen sink nutrical mixes morning / night with a heavy metals challenge (DMSA)) pee collection test. DOH!!! into the red lead and murcury and I eat clean clean food. But have over years risked questionable chinese style herb powders… Like the carrots seems to be a net negative health tactic!! I’m just mad as hell. I can hear it now, my Dr’s gloating over being “right”. Well he’s right! ;( Now I’ve tossed all the questionable powders, will try a water based lead test on a mixup of the powders disolved in water + vinegar (to disolve metalic lead). An experiment.


Dr Ward Dean of FL was pitching deprenyl. Dean really hasn’t been active with publishing, recent work. And any other orgs more recent human studies prob should be given preference. But here’s Deans advocation:


As stated previously, Professor Knoll is a man who ‘practises what he preaches’ and reportedly takes two 5mg Deprenyl tablets per week. We (Dean, Fowkes and Morgenthaler) recommend the following age adjusted titrated dosage schedule in our book, Smart Drugs 2.

Age. Dosage

30-35 1mg twice a week
35-40 1mg every other day
40-45 1mg every day
45-50 2mg every day
50-55 3mg every day
55-60 4mg every day
60-65 5mg every day
65-70 6mg every day
70-75 8mg every day
75-80 9mg every day
80 plus 10mg every day

Kitani and his colleagues (1996) found that the optimum dosage of Deprenyl, (which caused the greatest upregulation [increase] of antioxidant enzymes [SOD and CAT] in the brain in long-term studies) decreased by a factor of 5 (or 10). This was compared with the optimal dose in relatively short-term studies (3 weeks).

Unfortunately, by the time the results were calculated which showed the greater efficacy of reduced dosages of Deprenyl in long-term studies, Kitani’s group had already nearly completed another study using the much higher dose calculated from the short-term studies.

Contrary to the researcher’s expectations, the Deprenyl treated animals (given the high dose of Deprenyl based on the short-term studies), lived shorter lives than did the controls!

Kitani’s group is now repeating the study using the much lower Deprenyl dose that was determined to be most effective from the long-term studies.

Their work in progress appears to confirm that this lower dosage will result in life extension benefits for the Deprenyl treated animals.

Consequently, in view of the results of Kitani and colleagues, I recommend that my life extension patients consider the recommended dosages above as ‘starting dosages,’ and that they consider reducing their dosages somewhat after several months.

Kitani also concluded that ‘the proper choice of the dosage in long term experiments appears to be the key factor.’


Deprenyl hydrochloride (Selegiline, Jumex etc) is the prescription form that is most widely prescribed by the orthodox physicians.

Liquid Deprenyl Citrate (LDC) is Selegiline, which is considered to be superior. This form is generally recognised as the most pure and potent form of Deprenyl available. It also allows precise titration for anti-aging purposes, as each ml drop in the bottle is equivalent to 1mg deprenyl citrate.


I have been taking deprenyl on and off for a couple decades so I have studied it a lot. I currently take 7.5 mg am and noon. I have a SNP that up-regulates MAOa. I find taking a lot of dopamine agonists such as tyrosine and mucuna increase energy and motivation as well as mood. I got the deprenyl, an MAOb antagonist, prescription because I believed it would increase dopamine. It turns out it is much more complex.

“Taken together, our consistent findings across the two different approaches provide strong evidence that MAO-A, but not MAO-B, is engaged in DA degradation.”

" acute pharmacological inhibition of MAO-B by KDS2010 and selegiline did not affect either phasic or basal DA levels, which was inconsistent with the traditional belief."

“We recently reported that MAO-B-mediated tonic GABA inhibition in the SNpc (substancia nigra) is critical for DA neuronal dysfunction and parkinsonian motor symptoms in various animal models of PD… Our findings suggest that the therapeutic effect of MAO-B inhibitors could be attributed to blocking astrocytic GABA synthesis rather than to blocking DA degradation.”

So it seems my overactive MAOa SNP is related to that apparent dopamine deficit that is improved by dopamine precursors. It also explains why the 15mg / day of MAOb antagonist selegline did not reduce the amount of dopamine precursors I need for good mood, motivation, and cognition. Serotonin agonists do not help.

Before I discovered how to use dopamine precursors, I took bupropion and it worked well. I think I will cut back on deprenyl, restart bupropion, and cut back on the 18g/ day of tyrosine I take.

Deprenyl does not lead the “Cheese effect” associated with Tyramine at moderate doses.

“The much-feared “cheese-effect” (which can, among others, induce hypertensive crises) is not to be expected under therapeutic doses. At most a minor amplification occurs in the sympathicomimetic effect of tyramine.”


I believe Ward Dean still uses Deprenyl. The last time I looked, it was pretty cheap. It’s a small dose for life extension purposes.


I’m familiar with selegiline. I just can’t take MAOIs. It would be possibly fatal in my case with dexmethylphenidate and other interactions.

From my understanding, rare hypertensive reactions have been reported with typical oral doses when in conjunction with tyramine intake. Beware - one cannot be certain that hypertensive crises would not happen even if one sticks to lower than 10 mg.

There are just too many issues (ie serotonin syndrome) that can mess up dosing for this drug such that it’s not on my radar. Frankly, the acarbose interaction isn’t even the biggest issue for me (similarly applies to metformin and canagliflozin etc) but it is indeed a significant issue with enough unknowns for me to avoid in my personal situation.

Just as an example, estradiol (in BC) can easily increase selegiline concentration by 20-fold:

No reason for me to chase selegiline for now, so I don’t closely follow as of right now. However, if Dr. Matt K or another group happens to find solid data in dogs, I’d probably revisit it. It’s got potential just limited data with too many issues.


A little on the history of Deprenyl and aging:

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I have been reviewing information, thinking of taking deprenyl.

Came across the following, posting this PDF attachment.

deprenyl (1).pdf (6.4 MB)


He mentions a liquid product called DepPro near the end of the PDF you linked to. About 1mg of Deprenyl per drop. That would make it more convenient than cutting a five milligram pill into five pieces.

I found it online for $69.99 for 300 mg. So it would only be about $7 per month at their recommended dosage of 1 mg per day.

LEF recommends 10 mg per week. That would be about $10 per month.

Per info in another recent thread, Deprenyl was found to work synergistically with Polyscias Fruticosa in mice and rats. I just started making tea from it a couple days ago. (Aka dinh lang, or ming aralia).

I am considering more like 5mg per day.

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