For those of you who are taking Dasatinib, I am very interested to hear what side effects you experienced, and the extent of those side effects (IE: How long did they last).
I have just finished a course of Dasatinib 100mg 1day per week for 3 weeks. The first 2 weeks was with 1000mg of quercetin and then the 3rd week 1600mg Q + 400mg Fisetin.
A slight headache between the eyes within the first 24 hour period (enough to warrant pain medication);
A couple of mild waves of nausea (but no vomiting) the next day (but still with 24 hr period)
An intense but brief wave of nausea 6 days after the dose (but no vomiting)
A slight headache between the eyes within the first 24 hour period (but not enough to warrant taking pain medication)
A slight headache between the eyes within the first 24 hour period (no pain meds taken)
4 days later I feel a little off - not exactly nausea but something funny in the stomach and little fatigued
What symptoms did you have and how long did they last?
I’d love to hear your feedback.
When I take dastinib in the morning, I always get a slight fullness in the head in the evening. Its similar to a niacin flush, not quite a headache and not quite a flush. I expect to take one acetaminophen at bedtime to prevent it from interfering with my sleep.
I havent noticed anything beyond that.
thank you @CTStan!
How much Dasatinib do you take and how often?
Have only done it once, with standard 100 mg dose.
Within hours had nausea and headache. 12-15 hrs post dose, full out rigors. Not a pleasant experience.
thank you @KarlT
do you plan to try it again?
Aside from all these unpleasant side effects, has anyone noticed any actual benefits in their health parameters from taking Dasatinib?
Leaning towards yes, but wondering if the other senolytics are good enough to forego Dasatinib
@brandy111, I think it’s too early to say for me, since I just completed my third dose last week.
I’ll be taking some blood tests in a couple of weeks prior to starting Rapamycin.
Have you taken it yourself?
Basil_Dev: No, I haven’t taken dasatinib, fisetin, quercetin, or any other senolytics (yet).
KarlT: What benefit(s) have you noticed?
I’ve just completed a biannual course of dasatinib (100mg x 2 days) and quercetin (1200 mg x 2 days). I take it a couple of hours before bedtime. The first night I’ll have a low-grade headache that I can sleep through, and it usually clears by morning. On one occasion I felt the need to take some paracetamol. On the second day, I don’t feel much of anything.
I use an Indian generic, but I had the same side effect when I got the dasatinib from a compound provider in the US.
As for benefits, to be honest, I can’t really say I notice anything. For me, it’s a preventative intervention, so I’m not expecting much at this point.
@Bataille , I got the low grade headache as well.
I haven’t noticed any benefits so far either. I also use the Indian generic brand.
It’s good to know you had the same side effects with the compound provider, as I often wonder whether the Indian brand is the real deal, but I have no way of getting it on prescription here.
I have noticed benefits to my numerous supplements but don’t know if any benefits are due to senolytics.