I’m on all-nighter right now. About three hours ago, I took a cocktail of 200 mg of caffeine, 200 mg of Modafinil, and 1 mg of rapamycin. There is no interference, no cross-tolerance at all. I’m feeling really good and will soon embark on one of my projects. As part of my warmup, I am watching short videos of Richard Feynman, who puts all these YouTube influencers, all these would-be gurus, in the shade.
“The first principle,” Richard Feynman said, “is that you must not fool yourself and you are the easiest person to fool.”
What kind of effect do you get from Sulboutiamine Gemini as opposed to Modafini? How long does it last, does it affect sleep? I only take 200 mg of Modafini twice a week so I’m not losing its effectiveness.
I’m interested to know how you are finding using the both
Hi Dee. I stay up for 24 hours maybe once a week. It makes me more productive, more resourceful. And with the help of Seroquel, I can go to sleep at will and wake up 14 hours later. I find the whole experience to be blissful.
Thanks for that Tim, I googled Seroquel as I hadn’t heard about it. I see it can help sleep. I wouldn’t want to sleep for 14 hours but 8 would be nice after taking Modafini , I’m wondering what kind of dose I would take if it to get a good nights sleep . Do you get a mood lift from it? Or is feeling good the Modafini tablet?
Seroquel is known as a knockout pill. A low dose of 25 mg is what I take. The mood lift comes from the interaction of caffeine and Modafanil, but sleep deprivation is itself a key component. Restricting sleep has been found to be an effective antidepressant, which means that if you’re not depressed–or even if you are–you will get a major high by staying up for 24 hours or more.
“Sulbutiamine is a synthetic derivative of vitamin B1 (thiamine) developed in Japan in the 1960s to treat thiamine deficiency.”
Sulbutiamine does nothing subjectively. Probably because I don’t have a thiamine deficiency.
I could detect no noticeable effect even at twice the recommended dosage.
I am now taking 100 mg of modafinil in the morning. I was going to rotate modafinil with sulbutiamine. But I decided not to because on the first day I stopped modafinil, I had a lousy day. Modafinil taken in the morning at 200 mg fortunately did not have any noticeable effect on my sleep. I don’t get the boost I originally had with modafinil, but the morning dose of 100 mg definitely does something. Or am I addicted to it? My brain and body feel much better taking it.
That’s very interesting Charles. I have avoided taking Modifini daily as I like the feeling so much I didn’t want to become immune to it but you saying you take 100 mg daily might just be the answer
Well , I really value my sleep Tim and as I’m not depressed I will stay away from the ‘all nighter’ I play a lot of golf so I need to be wide awake. I’m thinking about taking my Modifini on a golf day to see if it improves my focus
Yes, lots of gators around here. I tried half today, not as up beat as taking the full 200 mg but if I sleep without sleep aids I will take 100 mg a day to see how it helps my game
I wonder if modafinil is more effective for the aged brain and body? Modafinil for off-label use is probably going to produce greater results in the elderly.
I have been taking modafinil off and on since July of 2025 in doses ranging from 50 to 200 mg/day. Currently, I am taking 100 mg of modafinil daily in the morning. I don’t believe I reported one of the benefits before because I wanted to make sure it wasn’t a placebo effect or due to confounding factors. The result of taking 100 mg or more of modafinil daily is that I have much more energy from taking modafinil. This results in getting much more work done daily. I am now accomplishing general yard work, gardening tasks, and other chores much sooner than it used to take me. Certainly, subjectively, it has a much greater effect on me than rapamycin or most other supplements I take. Have there been any studies or reports about modafinil and the elderly?
“A 2017 study assessed the effects of a single 100 mg dose of modafinil on resting-state brain activity in 24 healthy elderly subjects using fMRI, compared to a placebo group. The researchers speculated that modafinil-driven changes in functional connectivity may lead to enhanced synaptic plasticity, neurogenesis, and behavioral and cognitive benefits.” Frontiers
I think you are right about the possibility of Modafini enhancing the brain of the elderly, we are 80 so have experienced an improvement in memory, focus and energy with 100 mg and 200 mg. We both lost a lot of sleep last night so we won’t take it today. It’s a pity it affects sleep as we really like the affect of Modifini, if you have any advise on getting a normal nights sleep after taking Modafini we would love to hear it
I currently have a rather extensive drug-free sleep stack that I use. This works for me, and I get a solid night’s sleep. This, of course, is not a recommendation for anyone else. I go to bed at 11 PM and get up at 6-7 AM.
9 PM:
120 mg melatonin
500 mg magnesium complex
4 grams glycine
750 mg GABA
10 PM:
200 mg L-theanine
1 gm l-tryptophan
1.5 gm GABA
11 PM
Lights out
In addition, I have a completely dark room. I have automatic PIR night lights installed near my bed in case I need to get up. The nightlights I use are red to avoid affecting my circadian rhythm. I also have the same night lights installed near the toilet. By doing this, I have found it very easy to go back to sleep if I have to get up.
I keep my room at 70 degrees. I sleep better the cooler it is. Because of family members, I can’t keep my room cooler than this.
Yes, old people have to take more measures than young people to get a solid night’s sleep.
As a side note, you don’t have to use as much melatonin as I do. I take a high dose of melatonin for other reasons than sleep.
As a caution – and your mileage may vary, of course – it is my experience as someone with sleep challenges that a compound that may help me sleep (tryptophan, mag, glycine, taurine (not together), lecithin, theanine, progesterone, lights out, cool room, etc etc) rarely provides an offset to whatever it is that’s blocking sleep.
If I had found anything that could counter the (severe for me) sleep-challenging effects of (anything near a typical dose of) modafinil, I’d be over the moon to take moda again.
