New paper comparing 14 biomarkers of aging in elderly from the Berlin Aging Study II. The DunedinPACE epigenetic test emerged as the best predictor of mortality with several other biomarkers showing predictive capability. Other biomarkers such as CRP, gait speed, etc, did not (!).
Results summary
Results
In adjusted models of all-cause mortality, HGS, IL-6, standing balance, cognitive health, and the epigenetic clock (DunedinPACE) statistically significantly predicted mortality, with the epigenetic clock (DunedinPACE) emerging as the strongest predictor. CRP, gait speed, IGF-1, blood pressure, muscle mass, DNAmGDF15, FP and TUG were not associated with mortality in this study.
Results
In adjusted models of all-cause mortality, HGS, IL-6, standing balance, cognitive health, and the epigenetic clock (DunedinPACE) statistically significantly predicted mortality, with the epigenetic clock (DunedinPACE) emerging as the strongest predictor. CRP, gait speed, IGF-1, blood pressure, muscle mass, DNAmGDF15, FP and TUG were not associated with mortality in this study.
You can order the DunedinPACE test yourself (TruAge) for $500 and measure your pace of aging. Has anyone tried it?
As I am 85 years old, that wouldn’t be anything that I would be interested in doing. The probability that it would change any protocols for health span and life extension that I am using already is slim. Probably wouldn’t change the protocols of most members, as they are already on the affordable cutting edge of life extension protocols. Regular blood testing and the Levine calculator are good enough for me. If someone has money to burn, TruAge) for $500, might be interesting.
From what I can gather, the TruAge does have real power to show you the pace that you are aging. A score of 1.0 means you are aging at the pace of the general population. A score > 1.0 means you are aging faster, <1.0 means slower.
The interesting thing is that the test can show if an intervention, eg, a change in lifestyle (weight loss, increased fitness) is having a positive effect and slowing your aging.
If people are not satisfied with Levine and want a slightly more accurate free calculator based on standard blood tests as posted earlier by @Kebossit:
Humanity’s Bortz Blood Age Calculator
The most advanced biological age model based on blood tests available in commercial labs. Trained on 306k individuals from the UK Biobank database. It offers an 11% relative increase in predictive value over the Levine PhenoAge
Some might also want to consider looking at the ClockFoundation for information on Aging biomarkers, Use of Epigenetic clocks for clinical trials, or DNA methylation information.
Started by Steve Horvath