I take colchicine .6-1.2mg/day for Behçet’s and know many of you do for cardiac protection as well.
My concern is whether colchicine, a known neurotoxin, is actually a risky drug with respect to long-term effects on the brain.
As I understand, colchicine is a neurotoxin which induces Alzheimer’s in rats when injected into the brain. This is uncontested and the subject of many papers. However, we assume that it does not cross the blood-brain barrier because in overdoses from systemic exposure, death occurs from organ failure not direct CNS poisoning. However, from what I can tell, there is precious little actual evidence that colchicine definitely does not cross the BBB, OR that the limited extent it does, even if negligible in an overdose event, could cause cognitive effects over long-term usage (consider daily usage over 50-70 years) or even lead to Alzheimer’s later on.
What do we think of this: safe for daily use over years and decades, or questionable if your main priority above all else is neurological health and brainspan?