Coenzyme Q10 (CoQ10) U-shaped dose-response relation with blood glucose and blood pressure

#1

I found these meta-reviews and thought some here might be interested. Looks like for CoQ10, the dose makes the poison… The optimum seems to be around 100-200 mg/day: but is it the same for all people? Does it depend on your gender? weight? race? How do you make sure you don’t take too much? :man_shrugging:

Effects of coenzyme Q10 supplementation on glycemic control: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials 2022:

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Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials 2022:

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On the other hand, this other recent meta-analysis concluded that the optimal daily dose was 300–400 mg CoQ10 for “inhibition of inflammatory factors”. So there might be a trade-off here… Efficacy and Optimal Dose of Coenzyme Q10 Supplementation on Inflammation-Related Biomarkers: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials 2023

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CoQ10 - what do we think?
Angiotensin II receptor blocker (ARB) experiences?
#2

Not sure for all impacts of Co-Q10, but for glucose and blood pressure it seems that N=1 measurements before and after each adjustment of dose of time could help dial in the dose.

Do you like Co-Q10 outside of “take with a statin” contexts? For neuroprotection?

#3

Yes, for neuroprotection. It ranked high here: Parkinson Symptom Severity and Use of Nutraceuticals. But at 1200 mg/d and 2400 mg/d, it showed no benefits: A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease: No Evidence of Benefit

So, I wondered whether low-dose Q10 could be better for neuroprotection. And these U-shape curves signal it could be the case. 100 mg/d is probably the safest bet. At worst useless, at best maximizing the positive effects on BP and glucose :man_shrugging:

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