CoQ10 - what do we think?

#1

I struggle with trying to decide if I should still be taking this one or not. I’ve been on it at least ten years. It’s a pricey one when taking the Ubiquinol form.

There seems to be mixed evidence. Apologies in advance for not posting every study here since it is time consuming. Just want to get thoughts from smart folks here.

Some studies showing benefit for heart failure and others showing little benefit.

Apparently no effect on blood pressure, cancer, or statin related muscle pain.

Very interesting positive result when combined with selenium. Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly - PMC

Negative result showing it can reduce exercise benefits. Dietary Supplements for Exercise and Athletic Performance - Health Professional Fact Sheet

My issue with the studies is I don’t think they actually measured anyone’s CoQ10 blood levels. Seems like an important piece of data they leave out.

What are everyone’s thoughts on CoQ10/Ubiquinol?

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#2

I cannot find enough positive research to support taking it so I have removed it from my stack.

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#3

Also dropping it from my stack. I’ve been “mindlessly” buying/taking it for so many years that it’s just become a habit, but now I’m seriously wondering if it’s been inhibiting my training gains/goals this entire time.

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#4

not useful… maybe if paired with a statin

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#5

I should add that I only starting taking it when I started a statin, but I can’t find evidence that it’s even beneficial for people on statins.

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#6

i am taking Mito-Q, it is a modified coQ10 molecule, it seems to give me more energy and works better than CoQ10.

#7

I have it as part of my ATP enhancement stack, but I don’t have strong evidence for it or even an anecdotal response myself. It is, however, quite commonly used and part of the metabolism.

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#8

I’ve dropped it from my stack and have seen no difference. The evidence on this one is quite weak.

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#9

I think it’s an individual thing. I took it as recommended while taking a statin. I couldn’t say if I felt anything positive from coq10 as I definitely noticed a slow but steady decline in my cycling power after starting the statin. The coq10 didn’t stop that. After I started using GG my power has come roaring back. I am still taking co1q10 because I have some but I’m not planning to reorder.

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#10
#11

From what I’ve read, taking GG should be much better as it addresses issues way upstream compared to CoQ10. However it’s not cheaper, quite the opposite.

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#12

I got a CoQ10 blood test and the result was 0.77 (range 0.37-2.2), 24 hours after taking 100mg of regular CoQ10. And this was BEFORE I started taking 5mg Rosuvastatin

I figured that’s the low end of the range so I should be taking it to bump it up a bit. It’s strange I never hear anyone bring up blood levels since it’s a measurable thing, unless there are flaws with the blood test I’m not aware of.

#13

I think the most compelling evidence for CoQ10 are the studies when combined with Selenium.

However, the reduced exercise benefits might be the deal breaker that makes me stop it. I just worry that my blood level will get too low.

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#14

Reposting this here; not sure if CoQ10 is beneficial (as others said), but in any case, it’s probably hard to dose correctly given the dose-response pattern: Coenzyme Q10 (CoQ10) U-shaped dose-response relation with blood glucose and blood pressure

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#15

GG is on my list to try, but I have quite a long list.

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#16

sorry but what is GG?

#17

geranylgeraniol - GG

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