Carnosine Supplementation

Maybe I can summarize the amino acid interactions — please correct and edit this so we have the right interactions. From first glance, it would seem that we’d need to “dose” ourselves (with powder mixtures) at least three different points during the day to get glycine, taurine, and carnosine (and/or beta-alanine) to not compete. Plus creatine could be fit in anywhere.

Glycine competes with beta-alanine, and competes with taurine. It does not compete with creatine. I’ve heard glycine helps with sleep but for me it is too much at night so I take it in the morning.

Taurine competes with glycine and beta-alanine (above) and not with creatine. Taurine helps with sleep so better at night?

Beta-alanine doesn’t compete with creatine, but does compete with glycine and taurine.

Carnosine doesn’t appear to compete with anything.

I’m not sure how collagen fits in because (if I understand correctly) it consists of glycine as the largest component.

So, if you are taking glycine and/or collagen, and taurine, glycine and/or collagen should be taken at one end of the day, and taurine at the other. Or perhaps taurine at night and glycine at midday? (Many of us take glycine as a sweetener in coffee so this implies morning)

Creatine can be taken at any time. But if you are looking for exercise performance enhancement, it is best just before or just after exercise.

Beta-alanine can’t be taken with either glycine or taurine. Also if you are looking for exercise performance enhancement, it is best just before or just after exercise. so perhaps taking it in the middle of the day before exercise (with creatine) is best. Or take it first thing in the morning if you exercise then, and then glycine at midday. One caveat: athletic performance enhancement was seen in 3-6g per day of college athletes, but the itching occurs when more than 1.6g were administered at one time, so they appear to be dosing them every few hours of roughly 1g, so this suggests it will be a pain to take this multiple times per day. Or maybe you develop a resistance?

Carnosine can be taken with any of these. But if you are looking for exercise performance enhancement, it is best just before or just after exercise. So taking it with the beta-alanine and creatine just before/after exercise is best.

So if I were “dedicated”, I’d have daily:
o. 6g glycine, 15g collagen and 100mg NACET with my morning coffee (which I’ve done for 8.5 months) — I’m likely to stop the cocoa in the coffee because it seems the polyphenol concentration is too low to bother.
o. 3-5g Creatine (which I have for two weeks), carnosine, and/or 1-3g beta-alanine (not taking yet) just before/after exercise (for me this is midday/afternoon so timing works). I’m unlikely to bother with subsequent daily doses of beta-alanine because at some point this is getting ridiculous.
o. Taurine before bed. (Not taking yet)

Does this sound right? Does this sound overkill?

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AIUI Carsoninase which splits Carnosine into Beta Alanine and Histidine is in serum and cells. Hence if you take Carnosine it will to some extent be the same as taking Beta Alanine (and histidine)

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True (I believe). Which is why I suggested taking it on the same schedule as beta-alanine. Although I didn’t see any literature which specifically suggested an interaction in vivo of carnosine and the others, even with the expectation that it is transformed into beta-alanine/etc.

Thanks. The paper says:

“Carnosine supplementation results in a decrease in HbA1C, but elicits no effect on HOMA-IR, Cholesterol, fasting blood sugar, TG and HDL-C. “

I’m guessing this means Carnosine speeds up postprandial insulin release to lower A1C (estimate of AUC) but it does not improve insulin sensitivity (Homa-ir not changed). So it’s an insulin stage 1 help without helping stage 2 (steady state). Protein in general is reportedly a help in this same way for insulin resistant people.

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The point of contact for the paper;

Author

Peixiang He

View in Scopus

Department of Endocrinology, Yiyang Central Hospital, Yiyang, Hunan, 413000, China

Corresponding author at: Department of Endocrinology, Yiyang central hospital, Yiyang, Hunan, 413000, China.

hpx13607372305@sina.com

I’m very cautious with dosing and try not to overdo it. I also don’t take any supplement for a long time or consistently. Lately I’ve been on a break from almost everything.

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Probably wise, am inching in this direction.

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Anyone have access or the survival graph from https://www.liebertpub.com/doi/10.1089/rej.1.1999.2.337 ?

Abstract shows +20% longer p50 survival. This is the only lifespan data I found. I assume no p90 increase or it would have been reported.

As an amino acid in common diets safety should be good, if it demonstrates effect I wonder if it warrants placement among the other 4 known effective and safe treatments (rapa, Acarbose, glycine, taurine).

One would also assume the effect more pronounced for vegans who get about zero from diet.

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full article:

https://sci-hub.wf/10.1089/rej.1.1999.2.337

Full paper: Sci-Hub | Effect of Carnosine on Age-Induced Changes in Senescence-Accelerated Mice. Journal of Anti-Aging Medicine, 2(4), 337–342 | 10.1089/rej.1.1999.2.337
BTW Science Hub: has free access to many pay-walled papers. sci-hub.se

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Does anyone know why I can access the Sci-hub links ?
I just get a message saying ‘Safari can’t open the page because it can’t establish a secure connection to the server’

It might have something to do with my country of origin (UK)

‘ In other countries, such as the United Kingdom and Germany, courts have issued injunctions against Sci-Hub and ordered Internet Service Providers (ISPs) to block access to the site.
2 Jun 2023

It’s getting late here, so I’ll have another look at it tomorrow

Also liked to thank @desertshores , @Bicep and @jjrap1 for their help

I don’t really understand sci hub, just keep using it and it works. Maybe people couldn’t see the link I posted? Notice mine is sci hub wf, the other one is sci hub se. Here is a list of different suffix’s and some indication of how fast they are. Just pick one, they usually all work:

I know that occasionally she gets shut down and has to move to another suffix, but don’t think that explains this situation.

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Try another browser like Go Go Duck. Sci-hub seems to work fine on Google Chrome Browser.
You can also try the Microsoft Bing search engine.

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@J0hn, make sure you are using https://sci-hub.se/
You can’t get there without https( ssl ).

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This sounds like an internet provider issue blocking certain ip addresses.

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I think you might be right. I’m going to try and get the link via a VPN and see if that’s doable.

I get the same response via some ISPs

You shouldn’t probably link to sci-hub directly as you are using their bandwidth and people might be blocked.
Instead press the save button in the left.

image

And drag it to the reply window, so it’s uploaded to the site:

yuneva1999.pdf (6.0 MB)

You can also try anna’s archive:

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Yes, we can drag files up to 18 or 20mb in our messages here.

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