Interesting post! What about taking IP6 with Rapa? Any side effects?
I found this review/pro-opinion about myo-inositol. it could be a candidate substance for the ITP
From the paper
Factors that deplete inositol include:7 9 64 65
- Insulin resistance
- Elevated glucose levels
- Low sodium intake
- Caffeine (coffee, tea, etc)
- Kidney damage
- Intestinal damage
- Lithium
- Valproic acid
- Magnesium deficiency
The findings and insights from the people contributing to Rapamycin News are astounding. The contributors have greatly influenced the supplements and dosages that I take to stay healthy and hopefully extend my lifespan.
“Everything old is new again”
I notice daily clickbait articles and ads on my phone and computer.
Inositol was a minor fad way back in the days when I was following Durk Pearson and Sandy Shaw.
In any case, I remember taking inositol for quite some time. As with many of my supplements back then, I discontinued it because I felt no subjective results.
From the article, it is obvious that I was taking too low of a dose.
Maybe it’s time to revisit it.
This time I will take 4 grams daily for a while and monitor my glucose levels.
I think that inositol might be a good supplement for older people who gradually become more insulin-resistant
From other articles I have read this morning it may also have mental health benefits and may be a treatment for ADHD. Some forms of inositol may have anti-cancer properties.
@desertshores Huberman recommended myo inositol a few years ago. I took it for a while when I listened to him. I never noticed anything but I am thinking about starting again based on the paper.
Let us know what you find out!
In that paper it looks like myo-inositol is better than IP6 and almost as good as the IP6+myo-inositol combo to prevent colon cancer in mice.
Yes, i have been taking this since huberman mentioned it for sleep. It’s had zero effect on my sleep but I’ve been continuing to take it only because I have a ginormous bottle of it. I was so excited to finish it and never see it again, but now I may think differently.
If 4 grams daily of inositol does not lower my fasting glucose and A1c after 30 days I will stop taking it. I am starting tomorrow.
Does anybody know what dose the subject was taking? I can’t find it.
The patient was offered systemic therapy with both immunotherapy and targeted therapy but he declined both and instead elected to pursue the combination vitamin IP6+inositol (800 mg/220 mg), five tablets in the morning and five in the evening daily.
The patient went into complete clinical and radiological remission after being on the vitamin combination for 2 years (Fig. 2). Three years after relapse, the patient remains in complete remission and
continues to take IP6+inositol daily
We need the supplements to megadose. Inositol in food is low. Highest level is in beans, about 400 mg per 100 grams.
Amazon has it in powder form. Dang. And I have been buying the expensive capsules.
Has powder form to.
I do think that 4 grams daily of inositol has lowered my fasting blood sugar by about 2 points. I have some blood work coming up very soon so I will see if it shows up on my A1C.
Yes, the dosage is found here, full article:
Inositol hexaphosphate plus inositol induced complete
remission in stage IV melanoma: a case report
https://sci-hub.se/10.1097/cmr.0000000000000577
As I read the person was taking 5 tablets twice/day. Altogether 10 tablets daily.
Each tablet had 800 mg IP6 and 220 mg inositol. So the daily dose was 8000 mg IP6 and 2200 mg inositol.
Have understood the dosing regim in the case report correctly
Yes, but I believe that from my other readings it is the IP6 form that is active against cancer, not the regular or Myo-inositol forms.
The powder form from Natures Way at $33 for 100 day supply is only about 36% less expensive than the capsule form sold by the same company
IP6 capsules by Natures Way $31.52 for 60 day supply
The dosage taken by the melanoma patient was 5x the recommended dosage for normal supplementation.
I consider the capsule form more convenient to use and worth a small premium.
In particular, approximately 9.5 to 14.5% of the weight of rice bran is composed of IP6.
Phytic acid or IP6 is a polyphosphorylated carbohydrate with six phosphate groups, each attached to a carbon atom [3]. Myo inositol is the parent compound of IP6. The phosphate grouping in positions 1, 2, and 3 (axial-equatorial-axial) is unique for IP6 and suggests tremendous chelating potential [3], thereby it has a potential role as anticancer agent. According to previous research, IP6 exhibits a variety of chemopreventive properties, including antioxidant and anticancer properties [4, 5].