Thank you. A very interesting paper. IP6 becomes more and more interesting. I might do a 3-4 months high dose treatment.
In i similar intermittent fashion, that I do with nattokinase and serrapeptase.
“Furthermore, Singh et al. [7] have previously analyzed the anticancer efficacy of oral IP6 against human prostate carcinoma xenograft in vivo , in which IP6 suppressed the tumor growth without any toxicity. IP6 also has been found to be effective in animal tumorigenesis models of other cancer types without any toxicity [8].”
Colon, prostate, skin (melanoma). It suggests that IP6 might have a general effect on tumorgenesis.
The powder is said to be virtually tasteless and dissolves easily in water so you could add it to many drinks including coffee.
I have some powder on the way. I will let you know if I find it to be tasteless
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@desertshores: Which powder have you decided on? Per the article: “elected to pursue the combination vitamin IP6 + inositol (800 mg/220 mg), five tablets in the morning and five in the evening daily”. That’s 10 tablets/day. A powder that dissolves and is tasteless would be far more convenient! Coffee, smoothie …
I have ordered Bulk Supplements, a brand I have some faith in.
It is ~$0.07/Oz
https://www.amazon.com/BulkSupplements-Inositol-Hexaphosphate-Powder-grams/dp/B00JV4NUQM/ref=sr_1_2?crid=B9SIB2G17CJL&dib=eyJ2IjoiMSJ9.b1Szbfk0EYfKnoNmubz7RQ0jytKm75okqDMN-tEpQ6Hi8YkW5KgM6oZmzRQz26Sw62dxSuRh9_Sr43KqRNDdU_yYsBzAFMnEiSENgLjFDAMX0MIS-dluhOyuZb9hnabV0mk6XiSMHB6RDTirWuc8VOoUGS8BFAIzy3YOkjVKMskMFpbn8XhxkgiefJQS99boHdHhZ7jvrDtfTylVlQGDcQ.P31dF8bkABkBE9spmUKS6ew2h2WBYZGnex1F8PsHhM8&dib_tag=se&keywords=BulkSupplements.com+IP6+Powder&qid=1722440869&sprefix=bulksupplements.com+ip6+powder+%2Caps%2C434&sr=8-2
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When I used Myo-inositol has a slight sweet taste.
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The BulkSupplements IP6 has several complaints about the powder being rocky and not dissolving in water, raising questions about its purity.
In general BulkSupplements is not considered a top tier supplement company you can rely on without your own testing procedures.
Myo-Inositol has a chemical structure similar to glucose, and actually tastes like glucose, but half as sweet.
I’ll report on the quality of my supplement.
It does contain 9% calcium I don’t know why. That would explain some of the negative reports about solubility.
I didn’t notice this when I ordered.
After I finish this batch I will look for another source. I am not interested in getting calcium in a supplement form.
I cannot find any IP6 form of inositol powder that does not contain calcium or magnesium.
It is not clear from many suppliers what form of IP6 capsule form they are supplying.
In any case, I don’t think you would have any problem incorporating IP6 powder into a smoothie or protein drink.
Yes, but I am confused as IP6 comes in more than one form.
Which form does this supplement contain?
"Pure IP6: IP6 can be available in its pure form as a dietary supplement. In this form, it is typically extracted and purified from plant sources, such as rice bran or corn. Pure IP6 supplements aim to provide the compound without any additional minerals or compounds bound to it.
Bound Forms: IP6 naturally occurs in plant seeds and grains, where it is often bound to minerals such as calcium, magnesium, potassium, and iron. This bound form is known as phytate. When consumed in the diet, the bound form may have varying bioavailability depending on the presence of other dietary factors and the individual’s digestive health.
Supplementation: When purchasing IP6 supplements, it is important to check the label to determine whether the product contains pure IP6 or if it is in a bound form with minerals. Some supplements may combine IP6 with other ingredients to enhance its absorption or provide additional health benefits."
I wish supplement suppliers would be more detailed as to the source as well as exactly what their supplements contain.
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Most of the studies on cancer used the bound form.
One possible explanation is that IP6 is a mineral chelator and there is a warning NOT to consume IP6 at the same time as mineral supplements or food (since it may bind the minerals in the food or supplements, making them biologically non-available), perhaps the bound form (which is already bound to minerals calcium or magnesium) is designed to reduces the risk of binding to key minerals in the food or in supplements. However, even the bound form of IP6 recommends consuming between meals and not at the same time as mineral supplements, so presumably the calcium or magnesium in IP6 can be replaced by other minerals (eg iron) if present in high enough concentrations in food or from supplements.
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I have my own reservations about calcium supplementation, because of the association with increased CVD risk. But the studies pointing to the risk show dosages greater than 1,000 mg per day. The calcium in IP6 formulations is less than 200 mg. They may also be naturally occurring in rice bran, so may be considered dietary calcium. Dietary calcium is not associated with CVD risk.
https://www.tandfonline.com/doi/full/10.1080/07315724.2019.1649219#d1e289
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Another pure IP6 formulation is from Puritan’s Pride.
https://www.puritan.com/inositol-566/ip-6-inositol-hexaphosphate-510-mg-005745
Is Puritan’s Pride a reputable brand? Probably is. It is a subsidiary of Nature’s Bounty, which is owned by Nestle.
The FTC (Federal Trade Commission) order below is a consent order. The dispositive portion orders the respondents to cease from making specific health claims in their advertising. But the introductory part (identity of the respondents), states that Puritan’s Pride, is a subsidiary of Nature’s Bounty. Purity of products was not part of the complaint.
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