I’m not interested in debating this anymore than what I’ve done already. I stand by my conclusion that people should be careful about known or unknown risks when it comes to modifying biomarkers to extremes.
Since you asked for a source on ultra low LDL possibly increasing the risk of hemorrhagic stroke. Here is one reference for that: Does statin increase the risk of intracerebral hemorrhage in stroke survivors? A meta-analysis and trial sequential analysis - PubMed
I don’t have much more to say on this topic.
It is not related to ultra low LDL but statin and risk of ICH, the authors conclude statin still are a net benefit which is what matters and the patients who had an LDL decrease of more than 30% had lower risk of ICH, albeit still elevated, than those who had one below 30%. Which means that a greater decrease in LDL had lower risk with statin use than those who had a lower one. But thanks for making me aware of this risk.
Its completely fine to agree to disagree. In fact, Its going to be unusual that we agree here on everything. You guys handled it well here - brought lots of evidence to the table, disagreed respectfully… hopefully a model for future disagreements.
@Jblackbourn Hey Joe! I have not. We have some evidence with Rapamycin delaying menopause for women, but the small amount I have seen an either neutral or negative on testosterone levels and Rapa. HCG is usually effective in our younger male population, but usually not helpful as we gain wisdom 
It is impressive you have got in to your 60’s just on the HCG. It may be time to weigh out risks and benefits of TRT vs. other options.
Thanks for the perspective!
*this adds to my protocol above
So a while ago there was a post on here:
In response I found a local service offering whole body cryotherapy (WBC) and took up the monthly membership fee which included a weekly WBC. I have had 4 cooled to about -140 degrees Celsius for 3 minutes (although the average temperature may be higher than the final minute -140 C).
I must report that I feel fantastic. I have been doing the DAV protocol (see link at end) at the same time, but either individually or cumulatively they are really making me feel good.
After a WBC session I am positively near manic levels of happy. Endorphins rushing and cortisol levels through the floor. Highly recommended.
Could I wear an N95 mask when doing this, do you know?
I suppose it would depend where you went, but I couldn’t see any physical reason why not. The WBC chamber is open above the shoulders.
Update December 2023:
The stack could probably be further simplied but it’s still a really solid one imo.
Hey, we agree on something! Great stack. I don’t know why you use NMN when Niacin is cheaper and Lustgarten showed it works better. And for the TMG I use Homocystex plus which includes the right form of several b vitamins for me. Could be it works so well because of my MTHFR, don’t know because its complicated, but my homocysteine was 5 once and is always less than 9.
Thanks for sharing.
Can you talk more to TMG and homocystein?
I think saw that the trial Peter Attia uses to help patient lose homocysteine was based on a combination of B6, 9 and 12, but not any TMG. So I’ve been using that protocol (so far only one blood test back, but seems to be working).
I have to admit there is a lot about methylation I don’t know, such as whether it makes you older or not. Having said that I think I got the idea to try this years ago from chris Masterjohn and it had to do with the riboflavin 5 phosphate. They use pyridoxal 5-phosphate for the b6 and the methyl forms of b6 and b12. If you use homocystex plus then you get the TMG which is just 3 methyl groups added to glycine.
Honestly I think the homocysteine reduction comes from the B12, but years ago my homocysteine was more like 12 and I’ve been using this and it seems to work for me and it keeps me cooler as well. Kind of like the lithium. I’m going to say that comes from the folate.
Thanks @Bicep - above it was I am doing (just that the second b6 is actually b9) - is that what you mean too?
oops, no. I meant to say methyl forms of folate and b12. There’s no B9 in homocystex. And I doubt TMG has much to do with homocysteine.
Years ago when it came out I did 23 and me, found out I had snips of MTHFR and did some reading about solutions. Masterjohn had some, so I gave this a try. It is a fairly complex issue and since it was years ago I’ve forgotten most of the details of what I did there.
Great stack. Reminds me of my own.
Have you thought about adding taurine or lithium orotate?
Thanks! The SGLT2 inhibitor was not on my radar. Is that a stand alone or does it also pair with Rapa (like acarbose)?
You can pair an SGLT2 inhibitor with Rapamycin.
Mike Lustgarten goes in-depth:
The NIH interventions testing program found longevity effects also when taken alone without rapa.
There are at least two big threads on SGLT2i / Cana on this forum, just do a quick search