C60 and Rapamycin

#1

Hello Forum,
I was wondering if any of you are taking C60? There have been rat studies showing C60 can extend life. I haven’t seen many people on this form talking about C60 so I thought I would bring it up. Here’s some information from AI:

Combining weekly Rapamycin and daily C60 could have potential benefits due to their distinct mechanisms of action. However, there are also several important considerations and potential interactions to keep in mind. Here is a detailed look at both compounds and what should be considered when combining them.

Rapamycin

Mechanism of Action

  • Rapamycin: Also known as Sirolimus, Rapamycin is an mTOR inhibitor. It suppresses the mTOR pathway, which plays a key role in cell growth, proliferation, and survival.
  • Potential Benefits: In addition to its immunosuppressive properties, Rapamycin has been shown to have anti-aging effects, improve mitochondrial function, and reduce inflammation.

C60 (Buckminsterfullerene)

Mechanism of Action

  • C60: Known for its strong antioxidant properties, C60 can neutralize free radicals, reduce oxidative stress, and protect cellular structures from damage.
  • Potential Benefits: C60 has been shown to enhance mitochondrial function, reduce inflammation, and stabilize cellular membranes.

Potential Benefits of Combining Rapamycin and C60

  1. Synergistic Effects on Inflammation and Oxidative Stress
  • Rapamycin: Reduces inflammation by inhibiting mTOR signaling.
  • C60: Reduces oxidative stress and inflammation by neutralizing free radicals.
  • Combined Effect: Potentially enhanced reduction in oxidative stress and inflammation, providing better protection for cells and tissues.
  1. Improved Mitochondrial Function
  • Rapamycin: Enhances mitochondrial biogenesis and function by modulating the mTOR pathway.
  • C60: Protects mitochondria from oxidative damage and improves their function.
  • Combined Effect: Potentially greater improvement in mitochondrial health and energy production.
  1. Cellular Protection and Longevity
  • Rapamycin: Extends lifespan in various organisms by promoting autophagy and reducing cellular senescence.
  • C60: Protects cells from oxidative damage and improves membrane stability.
  • Combined Effect: Potentially enhanced cellular protection and longevity.

Considerations and Potential Interactions

  1. Immune System Modulation
  • Rapamycin: Immunosuppressive, which can increase the risk of infections.
  • C60: Generally not known to have immunosuppressive effects, but its antioxidant properties might influence immune responses.
  • Consideration: Monitor immune function closely, especially if prone to infections.
  1. Dosage and Administration
  • Rapamycin: Typically administered weekly, with dosage varying based on individual needs and medical guidance.
  • C60: Often taken daily in small doses, with some variations in dosing regimens.
  • Consideration: Adhering to the recommended dosages for both compounds and consulting a healthcare provider for personalized guidance.
  1. Potential Side Effects
  • Rapamycin: Can cause side effects such as mouth sores, fatigue, and increased risk of infections.
  • C60: Generally considered safe in low doses, but long-term effects are not well studied.
  • Consideration: Be aware of and monitor for any side effects, and adjust dosages or discontinue use if adverse effects occur.
  1. Metabolic Interactions
  • Rapamycin: Affects metabolism through mTOR inhibition, potentially impacting insulin sensitivity and glucose metabolism.
  • C60: Antioxidant properties might support metabolic health but interactions with mTOR inhibitors are not well studied.
  • Consideration: Monitor metabolic health, including blood sugar levels, and consult with a healthcare provider regarding any concerns.

Conclusion

While combining Rapamycin and C60 might offer synergistic benefits in reducing oxidative stress, inflammation, and improving mitochondrial function, it is crucial to approach this combination with caution. Given the complexity of their interactions and potential side effects, it is essential to consult with a healthcare provider before starting this regimen. Regular monitoring and adjustments based on individual responses and health status will help ensure safety and effectiveness.

#2

Adding some more C60 info:

Potential Benefits of Combining C60 with Metformin

1. Life/Health Extension

  • Metformin:
    • Mechanism of Action: Primarily used for managing type 2 diabetes by increasing insulin sensitivity and reducing glucose production in the liver.
    • Life Extension: Studies have shown that Metformin can extend lifespan in various organisms by mimicking caloric restriction, reducing inflammation, and improving mitochondrial function.
  • C60:
    • Mechanism of Action: Strong antioxidant properties, protecting cells from oxidative stress and damage.
    • Life Extension: Animal studies suggest that C60 can extend lifespan and improve overall health by reducing oxidative damage and supporting mitochondrial function.

2. Hereditary Spherocytosis (HS)

  • Metformin:
    • Indirect Benefits: While Metformin is not specifically indicated for HS, its general benefits for reducing inflammation and improving metabolic health might provide some supportive benefits.
  • C60:
    • Red Blood Cell Health: C60’s antioxidant properties might help reduce oxidative stress on red blood cells, potentially improving their stability and function in HS.
    • Oxidative Stress: Reducing oxidative stress is particularly important in HS, where red blood cells are more prone to damage.

Synergistic Effects

  • Oxidative Stress Reduction: Both Metformin and C60 reduce oxidative stress through different mechanisms, potentially providing a more comprehensive protective effect.
  • Mitochondrial Function: Improved mitochondrial health from both Metformin and C60 could lead to better overall cellular function and energy production.
  • Inflammation Reduction: Metformin’s anti-inflammatory effects combined with C60’s antioxidant properties might help mitigate inflammation-related issues.

Considerations and Potential Interactions

1. Dosage and Administration

  • Metformin: Typically prescribed in doses ranging from 500 mg to 2000 mg daily, depending on the individual’s needs and response.
  • C60: Commonly taken in doses of 0.5 mg/kg of body weight, often dissolved in olive oil or another carrier oil.

2. Potential Side Effects

  • Metformin: Common side effects include gastrointestinal issues such as nausea, diarrhea, and abdominal discomfort. Long-term use can sometimes lead to vitamin B12 deficiency.
  • C60: Generally considered safe in low doses, but long-term human studies are limited. Known side effects are minimal but can include mild gastrointestinal discomfort.

3. Metabolic Interactions

  • Insulin Sensitivity: Both Metformin and C60 might improve insulin sensitivity, which could be beneficial but should be monitored to avoid hypoglycemia.
  • Glucose Metabolism: Metformin lowers blood glucose levels, and while C60 doesn’t directly affect glucose, its overall health benefits could complement Metformin’s effects.

4. Monitoring and Medical Guidance

  • Regular Monitoring: Regular blood tests to monitor blood glucose levels, liver function, and red blood cell health will help ensure safety and efficacy.
  • Healthcare Provider Consultation: It’s crucial to consult with a healthcare provider to tailor the regimen to your specific health needs and conditions, especially when combining supplements and medications.

Conclusion

Combining Metformin with C60 could potentially enhance life/health extension benefits while providing supportive effects for managing HS. The synergy between Metformin’s metabolic and anti-inflammatory effects and C60’s antioxidant properties might offer a comprehensive approach to improving overall health and cellular function. However, careful monitoring and consultation with a healthcare provider are essential to ensure safety and optimize benefits.

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#3

We’ve had a short discussion on this before, I’m not sure that the data is quite there yet. See this thread: Use of Purple Stuff - C-60 as an anti-aging supplement antioxidant

Also: Anyone trying something a little more edgy? - #12 by GoldenCB

and: Anyone trying something a little more edgy? - #16 by GoldenCB

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#4

Nobody here has tried it.

You want personal experiences, try longecity. Look for the conversations with Turnbuckle.

1 Like
#5

That is helpful, Thank you