If it acts to reduce senescent cell load slightly then the effects will depend upon your initial senescent cell load. CRP at the lowest level tends to indicate the level of IL-6 particularly from SASP so it gives an idea of your senescent cell load. Can you say what your CRP level is?
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I’ve ingested c60 in olive oil before. Not the smartest thing I’ve done, eating buckyballs.
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@John_Hemming do you have any before and after data to share at all about the impacts of this protocol?
Also, where did you start in terms of dose and what led you to the point you are at now?
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This has failed to replicate multiple times since. But man, I swear I felt something from it haha.
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@RapAdmin have your numbers changed (either good or bad) since the trial?
When you resume Rapa will you go straight to 6-8mgs or ease into it 1mg a week?
I don’t know yet - need to get a blood test next week to find out. When I relaunch rapamycin it would probably be something like a 2/4/8 mg per week ramp. After using rapamycin for 3 years, I’m really finding how that its almost like taking an aspirin - I don’t notice any effects, whatever the dose is. Anywhere from 2 to 28mg / week has no obvious effect that I can determine without a blood test. I wonder if this is a common scenario for people - a sort of “acclimatization” to rapamycin over time?
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I’m up to 8mg a week and in a similar situation in that I’ve noticed no real effects apart from in the bloods (slightly raised lipids and ALT, slightly decreased WBC)….
I’ve just booked in for Echocardiogram and CAC next week. Then bloods in another few weeks time (going to see what the addition of Acarbose has done….been taking this for a week now).
Really interested to see if there are any changes in the Echo as I had one last year (before Rapa) that showed some slight functional declines……let’s see what 6 months of Rapa has done!
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Has anyone used or have insights into:
Stem cell therapy
Exosome therapy
Peptide therapy
???
When you do blood tests what is it specifically you are measuring, testing?
I’ve tried peptides, and bio-regulators. I’ve taken BP157 and TB4 orally and injected it to try and help heal some chronic tendon injuries.
I can’t say that it made any noticeable difference at least not in the short time. Both of my injuries have healed, but it didn’t happen immediately. So it’s really hard to say whether or not it made a difference. I had long standing ankle pain from an old climbing injury and it’s completely cleared up, but again, I can’t specially attribute it to the peptides. BPC157 as an oral supplement did help my stomach. I’ve had dysbiosis since taking a couple of rounds of CIPRO a few years back, but it the relief didn’t last all that long.
TB4 is anecdotally thought to improve thymic function, however it hasn’t been substantiated. I recently read a report from a self experimenter on the Fight Aging website who found that their thymus reduced after taking it, so buyer beware.
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I have a lot of data
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I did an c60 protocoll some years ago. It really increased my phycical performane (running 5k)
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RapAdmin, did I read your post correctly, that you have taken up to 28mg of rapamycin a week with no side effects?
Effectively somewhere around 28mg… 8mg with sardines and grapefruit. No obvious side effects but didnt do blood testing. And at that level I did push out the spacing to every 10 days to 2 weeks between dosing. My goal was to test high dose side effects (not to test mTORC2 inhibition by keeping blood levels of sirolimus constantly higher).
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Do you take the 28 mg every week? That is a high dose. I’m debating changing my 24 mg every other week to 12 mg every week…have not taken with grapefruit juice or sardines but doing some thinking on that. I have had zero side effects with the 24 mg every other week so thinking of increasing that dose.
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My vote is for s lower frequency. You dont want autophagy all the time.
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I may have missed a post about this already but have you done any blood tests to track changes in bio-markers based on different dosing protocols @lsutiger? When you say zero side effects does that include bloods?
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