Thats amazing. It has n come to my attention that chlorella contains that much spermidine. Do you have reference values for the content of spermidine in Chlorella? I just need some verification before I start buying C and put it in my shake.
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This is the source Bryan uses, all data is included in their site. Whole-Food Spermidine | PlantPills.co.uk
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I posted a paper a while ago on the forum, will try to find it and link it.
The average spermidine content in algae cultivated at 30°C was 1.9 mg/g dry weight (minimum 0.29 mg/g, maximum 2.24 mg/g).
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thnak you. It will be very useful. I read somewhere that different “strains” of chlorella have different levels of spermidine. If that is the case, then there is a need for me to find out what “Strain” of chlorella I am about to buy.
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I would not bother as in any case chlorella is quite inexpensive and by the paper I cited spermidine content indeed varies, but even minimum content gives you a great spermidine source. BJ chlorella is standardized to contain 1mg/g spermidine (which is not that high content if I compare it to the paper I cited) but it is difficult to source, since it has constant stock issues. I now buy some non Chinese chlorella that has a eco certificate and take it a bit more. Chlorella is a great source of minerals/vitamins and protein and vegetarian/vegan friendly and not processed food source so there a additional benefits to spermidine.
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which is a better source for spermadine? chlorella or wheat germ?
I wish I knew. I’m using both at the moment.
The latest Bryan Johnson experimentation… going where no man has gone before (I suspect)…
https://twitter.com/bryan_johnson/status/1696885514983317793?s=20
The drug he’s using:
I must admit i am drunk but “dick head” seems an apposite response. There is science and there is clickbait.
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Wheat germ is almost always listed at the top of the list for spermidine, followed by soy. While you can get some spermidine from chlorella, I haven’t seen it on any lists suggesting supplementing spermidine. Perhaps some other members have.
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Be aware that both chlorella and spirulina contain iron and some people, including me take it for that reason. Many people do not wish to increase their iron intake.
Interesting there isn’t that much difference in cost between chlorella and spirulina which I am currently taking. I suffer, perhaps because of old age, a tendency towards iron deficiency and anemia. They are both quite similar and both contain iron, but I see that chlorella contains more iron so I think I will switch to chlorella. Both seem to have a good effect on sports performance.
As for spermidine content, neither is a great source compared to wheat germ, soy, and several other foods.
“Spirulina sp., also known as “superfood”, a label given by the World Health organization (WHO)”
“Spirulina has received the most attention in humans; previous authors have reported spirulina to improve time to exhaustion whilst running (10, 11) and V̇O2max whilst cycling (13)”
“Twenty-one days of spirulina supplementation lowers heart rate during submaximal cycling and augments power output during repeated sprints in trained cyclists”
“Reports that spirulina can improve peak and average muscular force (15, 37) have led to one group of authors suggesting that spirulina’s high protein efficiency ratio (87%) and net protein ultilisation (92%) may have played an important role in achieving the positive results whilst administering alongside a training programme (37).”
“The nutritional composition of spirulina and chlorella makes them particularly attractive to biopharmaceutical and nutraceutical industries. Both contain high levels of protein (up to 65% dry weight), which include all the essential and non-essential amino acids (1), making them a plausible additional supplement to consider for vegetarians and vegans”
“https://www.sciencedirect.com/science/article/pii/S2213453018301435”
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This is not true. Chlorella contains same or up 10 times more spermidine as wheat germ or soy per study I cited above.
Wheat germ: 250-350 mg/kg
Soy: 180-350 mg/kg
Chlorella: 290-2200 mg/kg
Wheat germ also contains WG agglutinin (form of lecithin), a plant protein that binds specifically to sugars expressed, among many others, by human gastrointestinal epithelial and immune cells. WGA is a toxic compound and an anti-nutritional factor. It is among others pro inflammatory. So before supplementing WG it would be wise to check this out.
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Speaking of supplements, is anyone taking Atheltic Green or AG1? I have tried it before and tasted okay. But have not taken it consistently. And expensive.
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The reason I assumed that chlorella was not a big source of spermidine is because a quick Google search for best sources of spermidine will bring up articles in many of the popular health and longevity sites and even the ones that list supplements along with foods, chlorella is rarely found. Apparently, they don’t think chlorella is a food.
“United Nations World Health Organization (WHO) stated that represents an interesting food for multiple reasons, for example, it is rich in iron and protein and is able to be administered to children without any risk.” “Thus, microalgae can be an alternative to achieve food of high quality with a low environmental impact, because they can be cultivated in non‐cultivable lands.” Spirulina (a close relative of chlorella)
It really doesn’t matter to me, because I won’t be taking chlorella for its spermidine content.
I think we have had this discussion before on the pros and cons of spermidine in the thread:
“A Randomized Placebo-Controlled Pharmacokinetic and Metabolomic Study”
“A 2023 study called “High-Dose Spermidine Supplementation Does Not Increase Spermidine Levels in Blood Plasma and Saliva of Healthy Adults: A Randomized Placebo-Controlled Pharmacokinetic and Metabolomic Study” found that high-dose spermidine supplementation does not increase spermidine levels in the blood plasma and saliva of healthy adults.”
"Commercially available dietary supplements of the brand MoleQlar™ (Rottach-Egern, Germany) based on Chlorella algae powder and soybean extract were purchased, each “Interestingly, four of the 12 subjects still had higher AUC0-tlast plasma concentrations for spermine in the placebo intervention compared to the verum intervention.”
“Spermine derives from spermidine”
“It is rather unlikely that spermidine supplements with doses <15 mg/d exert any effect.”
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I bet he’ll publish a book All About Penis or something like that soon.
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All greens powders are expensive for what you get. AG-1 is among the most expensive. However if money is no object then they are convenient.
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“Shockwave Penis Therapy” … hmmm, not sure I’ll be signing up for that treatment anytime soon. Perhaps after the “head transplant” that will seem like a small step. Is this really a thing, a reasonable person might ask…
However, shockwave therapy for your genital health is indeed an expanding practice, one accessible even to those of us who aren’t eccentric tech executives. Stephanie Wolff, a sexual wellness expert, clinician and CEO of the Novus Anti-Aging Center in Los Angeles, tells Rolling Stone that interest in such technology dates back to World War II, when doctors observed that sailors who had survived depth charge attacks on submarines had internal organ damage from explosive sound waves. Researchers studied the effects of gentler shockwaves on human tissue for decades to come, and by the 1980s, physicians were using something called extracorporeal shock wave lithotripsy (ESWL) to pulverize patients’ kidney stones.
Meanwhile, research also began to show that these shockwaves could accelerate healing or regeneration of bone, tendon and soft tissues. In 2010, low-energy shockwaves were used as an experimental treatment for erectile dysfunction and Peyronie’s disease, in which a buildup of scar tissue can deform the penis and lead to pain and erectile disfunction.
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He also said he has a hard time even getting a date. So I wonder what the point of the penis injections are if it seems like he’s not going to be using it.
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I think it is reasonable to hypothesise that scar tissue forms when cells fail to differentiate properly and end up as senescent. Hence if you can kick them into differentiation you can get the scarring to reduce.
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I had always thought that scarring was due to your cells filling in a gap with collagen when there are not enough viable cells in the area to completely compensate for the damaged or missing ones.
Collagen is like the cement patches you fix your walls with. Your body uses collagen when it needs to create scar tissue.