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Maybe the title has to do with the inattention. But the referenced article is from an anonymous MD who declares:
I hold an MD and am currently in my residency. Related to the field I am in, for the past decade or so, it has been my hobby to hack my biology. If I want to improve something, I research it, decide on an intervention, implement it, track the results, and draw conclusions to find out whether something works for me or not.
The article is a commentary on some of Johnson’s biomarkers. Sorry. There is little content on Johnson’s Johnson, except to say that the Botox intervention is superb.
The part about Botox injections into his penis was superb and ever since seeing that my opinion of him was swayed from rather negative to rather positive – particularly because he is being public about this. I do think that this single tweet might have opened up a new industry…
Suggested ad - Botox, to make your face and penis youthful.
Below are some choice comments on the biomarkers:
He has 1.37 liters of subcutaneous fat. This is incredibly low and approaches body-builder-level territory. He calls this “optimal”. Subcutaneous fat is healthy – it is the visceral fat that is bad.
Some of his heart parameters are like that of a 70-year-old (“LV septal A’ mitral: age 70+; Aortic root diameter age 70+; LA E’ laterobasal: age 70+; RVSP: age 70; LV sepal E/E’: age 55). Despite being a doctor, I had to look up some of them myself. I will briefly explain what these mean.
- “LV septal A mitral” is a marker of diastolic function in the left ventricle. His value of age 70+ means that there is stiffness in the heart muscle, meaning that the heart can not relax as well during diastole, often associated with older age.
- Aortic root diameter: This is the diameter of the lowest part of the aorta. The diameter increases with age due to normal “wear and tear” (e.g., hypertension, overexercising). A large aortic root diameter predisposes to aortic dissection, which is very rare, but usually deadly when it occurs.
- “LA E’ laterobasal” is very similar to the first value. This measures the relaxation velocity of the lateral basal wall of the left atrium during early diastole (vs. the first value measures something similar but for the left ventricle instead of the atrium). It seems that the left side of his heart is not the best at diastolic relaxation.
- “RVSP” stands for right ventricular systolic pressure, which is an estimate of the pressure in the pulmonary artery, which is mildly elevated. My non-cardiologist understanding of the heart tells me that this could be related to the diastolic weakness of the left side of his heart. Pulmonary hypertension is a serious matter. Bryan has not commented on his pulmonary pressures as far as I am aware.
- LV sepal E/E’: age 55 means that his heart is about a decade stiffer than what we would expect for his age.
- Note: It is possible that his bad heart markers are due to a combination of overexercising + undereating. If this is indeed the case, then they will continue to get worse over the next couple of years unless Bryan changes key aspects of his protocol. Of note, structural changes to the heart are commonly observed in long-standing anorexia nervosa. It is also possible that his values are the way they are mostly due to genetic predisposition. To say for sure, we would need data on how these values changed since Bryan has been following his protocol.
- Disclaimer: I find cardiology to be one of the most boring medical specialties. Thus, I am not particularly knowledgeable about the heart.
Would be a nice addition to our MD members if the MD above joined this forum.
He takes rapamycin and dasatinib.