Bryan Johnson, Is he the New Poster Child for Rapamycin Use?

That’s the problem… you hear all these horror stories and how it’ll make you roided out and angry at everyone… wrong.

I was afraid to even think of taking it.

I’ve taken TRT for 4 years… what doctors discovered is a lot of that information was wrong. You’re not taking so much that it wouldn’t be normal in your system anyway. As we men age we lose testosterone like women lose estrogen. And we need these hormones in our bodies.

New information is coming out that it doesn’t damage your heart the way they once thought.
Link: https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(22)00115-5/fulltext

Yes, I’m glad I talked to my physician (he was on it already - I was gobsmacked) and we worked on a plan to get my testosterone up to high normal.

I believe TRT with the Rapamycin is a great combination for older men… keeping you youthful, strong and focused. Ready to live more good years.

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Last month, I said that I wanted to take acarbose, and my dr replied with, “I am thinking of taking you off of Jardiance.” I think I’ve been on Jardiance for 2yrs now after high glucose and A1C readings, plus weighing 235. I started taking supplements 2 to 3 months ago, and I cannot tell explicitly which ones are hitting my blood sugar and glucose readings (I have ideas) but over the last 6 months, now my readings are in the prediabetic range. If I don’t need it I certainly don’t want to be on it!

I think by the 3rd of mext month I’ll be signed up to take acarbose no matter what. If my drs take me off of Jardiance, I’ll sign up to take Metformin to keep blood sugar / glucose in check and to get my body ready to take rapamycin.

In 2023, I weighed 235lbs. Now I’m ~200lbs and want to drop weight to 175lbs in 2023, and maintain strict blood sugar readings. I have a glucose monitor to monitor it.

Just turned 63. Was signed up to start taking rapamycin at the beginning of May but chickened out. Now I’m getting everything else out of the way. Everything that I read says go for it! Thinking hard…but it seems more than likely I’ll be starting in 2023.

I lifted like a mad man when I was 35yrs old. 70 sets spread out over double sessions 3x a week, 30 sets every other day. One day off a week. Plus I did hapkido 3x a week, and a lot of jogging and bicycle riding while getting ready for a time trial and road race for the Iowa Games. I was around 205lbs and think I could have gotten down to 190lbs.

Not sure what my dr is going to say about TRT. He’s very cautious, and I think he will say no, but he may surprise me. I have an enlarged prostate, it is benign and am on Tamsulosin. I went through open heart surgery in late 2017 for a new aortic valve and 3-way bypass. They say that I have cardiomyopathy and this was diagnosed by heart MRI. I need a 2nd opinion on this.

I’m absolutely fine as far as I can tell. Just want to drop weight and live as healthy as possible for as long as possible. Going through a transformation.

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I am loving acarbose. No more diarrhea (probably from the metformin and Rapa) but a lot more gas. Also, have dropped 4 pounds which I am happy about!

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He’s a poster boy for a dystopian future, not for rapamycin

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More like a poster child for a freak.

Transforming like Michael Jackson.

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Let me remind you.

The Real spokesperson for Rapmycin.

Does the talk, the walk and has the documentation.

The standard to follow.

…“People who say it cannot be done should not interrupt those who are doing it.”… ~ unknown

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Such a sycophant :roll_eyes:

A common side effect of excessive testosterone… hubris.

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You will get use to it.

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hu·bris /ˈ(h)yo͞obrəs/ noun

  1. excessive pride or self-confidence.
    “the self-assured hubris among economists was shaken in the late 1980s”

Or? Maybe… Winning effect!

Hubris Similar:

arrogance

conceit

conceitedness

haughtiness

pride

vanity

self-importance

self-conceit

pomposity

superciliousness

feeling of superiority

hauteur

uppitiness

big-headedness

Hahaha. Maybe Maveric78 has something there.

Link: https://observer.com/2016/07/these-two-hormones-separate-winners-from-losers/

That said, I might be rolling on “T”… but better than being on cortisol - a common Brit problem. :wink:

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I think we need to applaud those individuals who are able to apply the practices and achieve outstanding results. Good on you @Agetron for setting an example for us all to follow.

Also, I truly appreciate your and @RapAdmin 's positive, friendly, and optimistic attitude. Also the camaraderie from everyone here at this site is excellent. That’s what keeps me here TBH.

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I just read this thread in its entirety. Some good musings, the tangent on investment strategy notwithstanding.

Personally, I have enjoyed keeping up on Bryan’s experiments and protocols. I am on a Rapamycin break as I heal from hip resurfacing in March. So trying other longevity hacks is all I have and some of Bryan’s are accessible and fairly low risk.

I have done super veggie every day for 3 months and I really like it and how it has effected my GI/micro biome. Hard to argue with 70lbs of great veggies a mo. I do some of his supplements too but frankly was already doing them before he posted blueprint. They aren’t that earth shattering. I am 4 times into his workout. It is quite good. A lot of it is taken from the knees over toes guys, but having strong knees is important as we age. I recommend it if you haven’t tried it. Post hip surgery I am not 100% in shape enough to do all the exercises fully but they aren’t hard to modify. I also have done his mouth/teeth routine. A 1-minute addition to my dental routine is worth it to me and I like the effects on my breath and how my mouth feels and teeth and gums look. Lastly, I am curious about red light so I may try that. I know many on this site have in varying ways.

When I see all the haters it makes me think of the man in the arena quote.

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Spoke to Dr. GREEN, my Rapamycin doc since 2018, and he recommended metformin as a better more sustainable way to get the acarbose (sugar control) affect without some of the stomach side effects of Acarbose.

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Yes - if acarbose is not working for you then metformin (or perhaps an SGLT2 inhibitor - did you talk to him about those?). metformin is likely fine.

See here: Canagliflozin - Another Top Anti-aging Drug

Have you tried a low wheat diet with acarbose? When I switched more to lentils and rice and away from bread/pasta, etc. - most of my GI issues went away with acarbose.

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Dr. Green indicated the mechanisms of acarbose and metformin are both attempting to manipulate IR and reduce the damage of higher free circulating blood sugar. His preference based on side effects and safety profiles was metformin.
“I think the acarbose study shows the benefit of glucose control.
So shows why metformin is good, increased insulin sensitivity
Acarbose decreases digestion of carbs.
Not convinced of benefit in humans.”

Acarbose is poorly absorbed into the bloodstream, and has a low systemic availability of less than 2% [84]. As a result, the risk of any toxic reaction is very low and, to date, no interactions have been reported between acarbose and β-blockers, sulphonylureas, angiotensin-converting enzyme (ACE) inhibitors or warfarin therapy [18].

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You know Bryan is getting famous when the Onion lampoons him.

I got a chuckle out of this, and hopefully Bryan has thick enough skin that he can too.

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Its great! And he definitely has a sense of humor about it all I think:

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Yeah… Bryan kinda asked for it once he started sharing his nightly erection data… and short term goals. Or, was that long term??? Hahaha :laughing:

The Onion couldn’t resist taking it further.

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Oh my, this is just the laugh I needed today (for longevity purposes since laughter is the best medicine)!!!

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