I don’t care, if people don’t list what their LDL or apoB is.
Everything is completely irrelevant if they don’t.
If their apoB or LDL isn’t at youthful levels to prevent atherosclerosis, it is all very much irrelevant as they will bottleneck their longevity with cardiovascular disease.
I agree re: hormesis and the need to cycle supplements. I don’t think we’re anywhere close to actually knowing how to cycle them though, and each of us is guided by little more than intuition.
However, looks do matter. The guy looks in his 40s or spectacularly good for his actual age — unless he’s doing other cosmetic stuff that he hasn’t disclosed in his regimen, which I don’t rule out. I’m not at all saying now I’m going to imitate his stack but I am saying I have reason to be less worried about mine (which was far less out there to begin with). One of my biggest fears re: supplements is the presence of damaging contaminants so I like to see guinea pigs like this dude or Bryan Johnson literally not getting killed by popping 150 pills a day. It gives me peace of mind that if only I choose the right stuff for myself it won’t likely bite me in the ass.
I think some things are becoming clearer. Hormesis is clearly about autophagy and particularly mitophagy and increasing mitchondrial efficiency. That is the response to the ATP/ADP gradient. Cycling depends on the cycle. A key cycle is the anabolic catabolic cycle. I personally am pleased because i have now managed to cycle back to a heart rate below 50 BPM having boosted my metabolism. It ia good to know that boosting works, but there are limits.
I couldn’t agree more. I’ve actually shared some of my own thoughts and speculations on crafting a combinational strategy for supplement cycling in a post here (Efficient Combination of Longevity Strategies). Unfortunately, there hasn’t been a substantial amount of feedback or alternative perspectives in the forum.
This site will be an ever-changing document based off of my experimentation, learnings, and philosophy as it continuously evolves, so check back in from time to time to see how it has changed. I am usually updating something somewhere nearly every day. I have “firm convictions loosely held” and am always willing to change my thoughts and ways as new information emerges.
I was thinking today that I take 11 vitamins/supplements a day plus rapa once a week, and taking more than that - not even close to as many as what this guy takes - would drive me nuts.
I have just started buying frozen salmon from the grocery store, which costs €1.35/100g. It tastes fine in a well seasoned dish. Approx. same price as high-end fish oil.
You might be right. But I think a lot of clinicians, including myself, are erring on the side of caution and sticking to the " tried and true" 6mg/wk.
However, AgelessRx is trying to collect enough data on sirolomus levels in the hopes of trying to figure out if there’s a correlation between Sirolomus levels and side effects or outcomes.
For those who are brave enough to try different dosing protocols, please continue to collect data and report back. Hopefully, we can find a mechanism to capture all this data and put it to good use.
It would appear that TA-65 is also known as Cycloastragenol. Instead of paying $570 for 90 days supply of TA-65, Nootropics Depot has Cycloastragenol available for $99 for 90 days supply. At that price perhaps it might be worth trying along with some telomere testing?