I’ve been searching a big on Apelin to learn more. Here is one quote from the book “Defying Aging”
“Another important myokine is called apelin. Of course, its levels decline with age but are boosted by exercise. Its effects read like a fountain of youth: stimulating production of new mitochondria, facilitating protein synthesis, and helping muscle stem cells to function.14
Our skeletal muscles suck up a large proportion of the sugar circulating in the blood. As we lose muscle, blood sugar levels can rise contributing to an age-related risk for type 2 diabetes. Conversely, exercise stabilizes blood sugar levels.1”
From the sounds of it, it will be competitive with drugs being developed that target Irisin: Irisin Ameliorates Age-associated Sarcopenia and Metabolic Dysfunction
Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine
Apelin_ijo.2013.158.pdf (1.2 MB)