I would say some of these interventions (the endogenously produced one like NMN) are more helpful when you are older not younger, they’re just ironically also more risky when older because the chances of cancer are higher. It’s possible that the body is deliberately downregulating production of these compounds with age in part to reduce the risk of cancer.
My guess is that it has a lot to do with loss of immune function. The majority of cancers begin to appear during middle age. Same goes for infections. We slowly begin lose the capacity to deal with any negative consequence that our younger bodies could cope with. Homeostasis becomes harder and harder to maintain.
Exactly. I think declining immunity is the main reason cancers become more common with age.
A recent British show on longevity research in California, including some coverage of the BioAge Apelin drug:
Interview with BioAge VP: