Valter Longo & team strike again. Low protein mediterranean centered diets, strategically supplemented with select aminoacids get the best longevity results.
Methionine-supplemented longevity diet increases growth hormone, GLP-1, and FGF21; reduces frailty; and promotes healthspan
https://www.sciencedirect.com/science/article/abs/pii/S1550413126002251?via%3Dihub
Pop-sci article:
Low-protein, amino acid-supplemented ‘longevity diet’ linked to longer healthy lifespan, lower fat mass and frailty risk, and better metabolic health
https://www.eurekalert.org/news-releases/1133115
"A plant- and fish-based, low-protein diet paired with small amounts of an amino acid commonly found in eggs, meat and dairy increased healthy lifespan and decreased frailty and fat mass in mice, according to a new USC study published today in the journal Cell Metabolism.
The researchers, led by Valter Longo of the USC Leonard Davis School of Gerontology, also worked with University of Toronto and Harvard University colleagues to analyze existing data on the diet and health of more than 200,000 people. The team found similar health advantages of a more plant-focused diet, including less obesity and Type 2 diabetes.
The combined data from mice and humans indicate that the best health outcomes may be obtained by following a “longevity diet” that’s largely vegan or vegetarian, but with fish added, Longo said. The Mediterranean-inspired diet provides a small but sufficient amount of methionine and other essential amino acids."
“Additionally, human data showed that participants who ate the highest levels of animal protein — therefore consuming the highest amount of methionine and other essential amino acids — had a higher prevalence of obesity and twice the rate of diabetes compared with those consuming little to no animal protein. This persisted even though those eating more animal protein had a lower calorie intake and otherwise healthier nutrition, Longo said.”
