Anyone using - Trehalose? Therapeutic activation of autophagy by combined treatment with rapamycin and trehalose

[Katherine_Fisher]

Therapeutic activation of autophagy by combined treatment with rapamycin and...

[Joseph]

FWIW

There is another thread on this site about trehalose, not with rapamycin.

I have been using trehalose in coffee{coffee is the delivey vehicle] with other added supplements in the coffee.

Review, if you have not seen/read.

Fighting Alzheimer’s with Increased Autophagy via Rapamycin + Trehalose

Good news for all the rapamycin autophagy fans here: In this study, the researchers sought to investigate if targeting mTOR-independent autophagy with trehalose in addition to the mTOR-dependent pathway with rapamycin would bring additional benefit in a mouse model of Alzheimer’s disease. … Trehalose treatment significantly upregulated autophagy in the hippocampus and frontal cortex, while the combined treatment was more efficient in inducing autophagy than monotherapies in the amygdala and dentate gyrus. Conclusion This study shows that the induction of autophagy by trehalose alone or in combination with rapamycin in general is more beneficial than rapamycin-only treatment in an animal model of AD. This points out the importance of activating the mTOR-independent pathway to add…

[desertshores]

Thank you. I do a lot of searching on Google Scholar, but frankly, it never occurred to me to pair trehalose and rapamycin.

[desertshores]

Maybe I will dump a bunch of trehalose into my grapefruit juice before I dose with rapamycin.
Seriously, I am going to do it.