What about cognitive impairment?
No, not even joking here. Given your past history, I am seriously concerned as to whether your grip on reality is sound. Please seek medical counsel.
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not encouraging anything for others as they can do as they please and the ketamine was NOI a street drug but produced by commercial pharmaceutical medical companies in an injection vial for anesthesia and which also sell various other substances to pharmacies.
And i never bought anything from random company in china.
I bought from one that sells api’s and do their own testing with official papers of purity and details. And calculated risk taking is exactly what the other users who comment are NOT doing = no numbers, no probabilities but mainly only emotion.
PS i am doing small doses much less than the equivalent most successful experiments on mice.
i don’t see any cognitive improvement for sure and neither does anyone else other than placebo effect i would bet. And i am not so insane as to go to some quack medical attention.
if i did that then i would be nearly insane .
Dan - would you please share the name of the company you purchased from? I’m curious. Most of the companies selling rapamycin (and most chemicals more generally in China) are just middlemen.
It doesn’t matter if the ketamine was from the street or a pharmaceutical product. What does matter, is that you’ve been taking it, and at what seems to be very dangerous dosages. You also mentioned LSD (and I assume many other drugs), and that you do these drugs "for the thrill" rather than for any medical purpose.
This suggests to me that you may be an abuser of drugs that happened to wander into longevity drugs. As a result, I don’t trust your relationship with these drugs, as you appear to be taking them on a whim, or for kicks. That is not a safe way to do this.
You are literally contradicting yourself.
In one post, you say that you get your rapamycin powder from China, along with other drugs, for 8 years. Now you say you haven’t bought anything random from China. So which is it???
That’s just what they report. You do realize that these sketchy foreign vendors aren’t held to the same standards as other countries, no?
This is just like when a company conduct an “internal investigation” in order to determine if one of their abusive CEOs has done anything wrong, and finds them innocent. Unless the reports have been corroborated by other independent labs or regulatory agencies, it’s literally just a piece of paper that says “trust me bro.”
Uh, have you even been reading anything? Everyone is reading the data. Everyone is reading the numbers. Everyone is doing the math.
That is literally what this forum is for, discussing the data.
This, ironically, appears to be what your criteria are - you seem to just inject random drugs into yourself based off of the “thrill” as you’ve said yourself earlier!
Plus, I haven’t seen a single post from you yet where you actually state any “numbers” aside from the insane doses you’re taking.
20-30 mg of rapamycin injected every 5 days is NOT a small dose! That’s a HUGE dose!
Again, you should probably check for the opposite trend.
Going to seek medical attention, when you need it, is quack!?
You literally said, in your other post here, that you injected tap water from the Phillippines into yourself! TAP WATER!
And not only that, you got an infection! Do you realize you could have lost the limb you injected that contaminated water into, or even cost yourself your life?
I think you already are insane. If you think modern medicine is quack, yet you saw no problem at all injecting tap water from a third world country into yourself, then you’re certainly going to beat these so-called quack medical professionals to one thing - the grave.
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isopropyl - no not at all and what you thought is very wrong. The ld50 is only about twice that of ethyl and it has been injected along with other substances in small amounts in many instances in the past and for nano emulsions isopropyl is used rather than ethyl in at least one article. For example for onr instance Google ’ Rapamycin-Loaded, CapryolTM 90 and Oleic Acid Mediated Nanoemulsions: Formulation Development’ though u could likely find the article with less words… Set a record for what ?
Everything else being equal i would expect iso-propyl replacing ethyl to ‘sting’ more than ethyl in those cases where one could sense it at all.
That is not at all the case nor anywhere close to what i said but more like the opposite. Other than i sure as hell don’t need medical attention and that is a quack statement. Other than that If it is science with numbers and proofs that is one thing and is of relevance. If it is just ones opinion with no direct proof nor even probability then that may be quack. I credit my success for one to ’ DO NOT EVER EVEN CONSIDER another persons opinion without direct proof. A good example of that is the statement just made " Do you realize you could have lost the limb you injected that contaminated water into, or even cost yourself your life? " that is so shallow and trite to even make a statement. I could say do you realize you could get in a traffic accident and die which is much more likely. That is what i mean by relative probabilities. My god if someone could consider all things that ‘might’ happen that is ridiculous as it is infinite.
It’s possible you set a record for the highest blood concentration ever. I could be wrong, but a blood test would prove it. That’s all I’m saying.
I think ketoconazole is for the oral route only. It suppresses the cyp3a something in the gut. You’re actually getting the entire dose, so 100% of injectable. With or without the keto.
If you took 30mg injectable at once, then checked blood levels in about 5 minutes, I’d be willing to put money down that you set a record. Not a good record to set, but I’m pretty sure.
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lol this is great stuff
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Welcome to a site of personal opinions.
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Not too long ago there was a thread about static magnetic fields extending healthspan and lifespan in mice.
There are costly, high-powered magnetic mattress pads you can buy that go under the mattress. You want a uniform downward (negative) field.
More information available in this thread:
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i have had blood tests but not 5 min’s after. And as you read more articles here u will see cases of injections much much more like in the 100’s of mg’s. You will also see many times of articles stressing ’ overdoses of rapamycin are usually NOT serious’
PS i am not saying that formula you presented is not important as it and the many like it are one of the most important aspects. But Also i did not profess that i myself was especially knowledgeable in biological practical(or theoretical at the larger than quantum level or ab initio…) chemistry. I just said doctors etc. who many patients think ‘know it all’ and some indisputable gods don’t know even much more simple ones in one indeterminate ,x, say though yea that may be a poor example of what all they don’t know or are just say any opinionated remarks to their own gain or to save time (eg maybe they don’t do a particular procedure and then just tell u some unimportant detail or some what is wrong with it because some one out of a billion patients has a bad reaction which has hapenned to me more than once.) and you as the patient are expected to take it as the ‘gospel’ with no backtalk.
AS TO that formula you wrote i really would like to become more familiar it and the multitude of others.
ketoconazole does not only affect oral though the factor of say ‘multiplication’ is more than for injections. I have just recently read articles(s) on that very thing - injections of rapa compared to with keto… and not and it had a very definite increase in effect such as blood levels, peak concentrations etc.
@Bicep please do not heed any advice from this wacko.
His information on isopropanol is exrtremely uninformed an inaccurate, as he seems to just willy-nilly Google shit without even bothering to READ THE SCIENCE!
For instance, this is factually incorrect:
He just googled “isopropanol LD40” and the first result of that is dermal LD50 on rabbits, which is 12.8 g/kg. That is not oral LD50, and it certainly isn’t injected LD50 which provides even more bioavailability than oral (meaning a smaller dose is equal to a larger oral dose).
If you compare that to the oral LD50 of ethanol, which is 7-12 g/kg in mice, then you can see how Dan came to the conclusion that isopropanol’s LD50 is twice that of ethanol. That is incorrect.
The opposite is actually the case - isopropanols oral LD50 in mice is ~5 g/kg. In other words, the LD50 of isopropanol is half that of ethanol.
Anyone with basic knowledge of biochemistry knows why - longer chained alcohols produce metabolites that are increasingly toxic to the body. The same goes for the opposite direction with methanol, having one carbon atom fewer than ethanol, which metabolizes to formaldehyde in your body.
Isopropanol thankfully does not metabolize into anything as horrible as formaldehyde, but it is avoided in pharmaceutical preparations for many reasons. For one, because ethanol exists! Isopropanol comes with far more side effects than ethanol, which is why it’s avoided whenever possible. The only reason Dan uses it is because he literally buys 70% rubbing alcohol from Walmart. Not joking. Here’s his post:
Furthermore, the paper he is citing that uses isopropanol is a purely explorative developmental study. In other words, just proofs-of-concept. They weren’t even tested on mice, just cell lines.
These formulation studies are done as a demonstration to say “hey it’s possible,” not as a direct-to-pharma preparation. For fuck’s sake, Dan, it says FORMULATION DEVELOPMENT in the title! Along with the words “Toxicity and Assessment!”
But you intentionally left out that last part of the title. The full title is:
Rapamycin-Loaded, CapryolTM 90 and Oleic Acid Mediated Nanoemulsions: Formulation Development, >>>Characterization and Toxicity Assessment<<<
I don’t know if you are being intentionally deceitful by omitting such an important detail, being that this is a toxicity study. I don’t know if you’re just ignorant or maliciously trying to cause harm to others in this forum by spreading misinformation. But to be honest, both cases are equally as bad.
It is often the people who refuse to seek modern, science-based medicine that end up reintroducing measles to the world.
I don’t know why you have a grudge against medicine. I have my own grievances against the system, but it is almost entirely due to the regulatory restrictions that hinder medicine, not the medicine itself.
That is exactly what you are doing. You’re throwing out all of these wildly incorrect, demonstrably false facts that have no citations, no evidence, and no reasoning other than “for the kicks.”
You have rejected every single citation, fact, and evidence that I have provided you. You seem to just believe what you want to believe, not based on proof, but on what you feel.
And you aren’t successful. You injected yourself with non-sterile tapwater from the Philippines and use Walmart rubbing alcohol in your injections, too. And surprise surprise, you got an infection from that!
Shallow and trite? So this statement of factual medical reality, is shallow and trite? And not backed by proof? Are you joking?
No, it is NOT more likely! Where are your sources? Your math?
This is demonstrably false!
An estimated 1.3 million lives in the US are lost due to unsafe injection practices, mostly related to opiates and drug abusers (which may fit your description, given your past psychedelic/ketamine injections).
Compare that to annual automobile-related mortalities in the US in 2020:
A total of 35,766 fatal car accidents for 2020. Since you won’t do the math, I’ll do it for you:
Your unsafe injection practices make you 36 times more likely to die than car accidents. Now, let’s factor in the estimated number of injection drug users within the US, which was projected to be about 3,694,50 in 2018:
Now, not all of these persons who inject drugs (PWID) do so in a dangerous and abusive manner, but let us assume the worst case scenario that all of them are drug abusers.
That means you have an annual risk of injection-related death of approximately 1 in 3 PWID. I hope you can see now why unsafe injections are such a crisis in the US and worldwide. It kills so many people that we literally have to sweep dead people off the streets in many cities of the US. This is one of the reasons why cities like LA are such hellholes nowadays.
Which is why we have to look at the data and do the math. What you’re doing, as I have calculated, isn’t something that might happen. It is extremely likely to happen, especially if you continue this behavior. This is why I am telling you to seek medical counsel. You need both mental care and drug rehabilitation.
No, it is the fact you don’t know it that demonstrates to me your lack of knowledge on what you are doing. You bragged about being able to do a simple high school derivation of calculus as if that makes you an expert, yet you can’t even recognize one of the most basic of pharmaceutical equations.
That equation was for plasma concentration, by the way. The fact you didn’t even bother to Google it speaks volumes of your willingness to actually research and validate information.
Quantum level biological chemistry? What the hell is that? Do you even know what you’re talking about? I hope you aren’t being serious.
They aren’t “know it alls,” the only one acting like a know-it-all is YOU. And like I said before, those doctors obviously know how to derive a simple calculus equation. Whereas you cannot even recognize the plasma concentration formula, a damned introductory pharma equation that you could’ve Googled. I didn’t even ask you to solve it, or derive it, just to name it. And you didn’t.
Danny boy, when they tell you not to inject yourself with tap water from the Philippines, perhaps you should listen.
Now let me turn one of your one-liners unto you.
I asked you to name a basic pharma equation, and you couldn’t come up with an answer on the spot. What does that say about what you know?
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Isn’t that mostly because of drugs laced with or usage of Mexican fentanyl made with Chinese precursors?
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That is one factor among many. Like I said before, I just made an estimate because there are far too many variables to make an accurate projection. Overdosing from miscalculated at-home measurements, infections and death from non-sterile needles and/or drugs, etc.
Also, as you said yourself, that fentanyl had Chinese precursor chemicals. The purity of such precursors often determines what toxic byproducts are produced, such as formaldehyde. Dan gets almost all his chemicals from China, as he says himself, and he does nothing to verify their purity.
What Dan is doing is a combination of the worst unsafe injection practices.
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He is likely doing everything non-sterile
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He purchases from foreign countries (China) with no assurance as to their quality and/or contaminants, and uses concerning budget ingredients like Walmart isopropanol in his injections
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He doesn’t seem to understand how to measure out dosages and since he refuses to interact with any doctors he has zilch in regard to monitoring his own biomarkers for anything dangerous. So, he is at risk of OD’ing, which can be seen in his excessive 20-30 mg per 5 days injection routine of rapamycin
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He takes and has taken a myriad of drugs which are easily abused, such as psychedelics, ketamine, growth hormone, etc.
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He’s got to be trolling us?
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O_o
This person is FU.
If he in not, he is writing this to get attention.
Why use your time and energy to try explaining?
If people ignore him all on this forum would be better off.
This is my view.
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