Anyone tried Astaxanthin large doses daily at 15-100mg daily? Most people take 6-12mg daily. Asta is one of the few compounds shown in the ITP to extend median mouse lifespan by 12%.
It is postulated to work via the NRF2 pathway which upregulates GSTA4 enzyme.
Interestingly, if you follow David Sinclair’s OSK research, Ryan Lu recently published a paper showing that OSK mainly works because it upregulates GSTA4 enzyme.
I cannot include links it seems but if you go to biorxiv or Google and search for ’ Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision’ you can see the paper.
In other words, it seems like OSK partial reprogramming and Astaxanthin and probably other medicines work mainly because they activate GSTA4.
The research on Astaxanthin is very interesting and there is a lot of concensus it seems to improve cognition, prevent wrinkles, bla bla, all the anti aging effects in mouse and increasingly in humans without and toxic side effects.
I have been taking 12-16mg daily for months, so far so good.
But to activate GSTA4 enough to achieve an anti aging effect, I think from what I read, a dosage of probably around 100mg/day is required. And I am not crazy enough to try that dose.
I’ve been taking natural astaxanthin for about a year and a half. I’m currently at 24 mg/day, though I tried 48 mg/day for a while. I think it may be helping lower my CRP a bit and possibly improving UV protection, but it’s difficult to be sure. I haven’t noticed any side effects.
I dialed back to 24 mg/day because I was concerned the higher dose might be lowering my DHT more than I intended. I may try a higher dose again at some point and retest.
The DHT inhibition effect is only significant in-vitro. In vivo even a combination of high dose astaxanthin and saw palmetto only had a relatively modest effect on serum DHT levels.