Anyone taking Nattokinase? Why not?

So, are you blaming your high LDL on your weight, Covid, Pfizer, or the vaccine?

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I think if the government (owned by Pharma) forces you to take an experimental shot, you can feel free to blame them for any physical ailment you subsequently encounter. Vote accordingly and notice when they change your vote.

My opinion on this subject is in the vast minority here. People only see the news they want to see now.

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But how will you avoid the nanomachines bill gates put in your air supply? Checkmate.

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I did. We lost. lol.

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Nicely done Karl, et. all. :ok_hand:

Anyone try to replace Xarelto with Nattokinase? I’m on 10 mg of xarelto daily for past DVT’s (blood clots) but wondering if a daily low dose aspirin along with Nattokinase (but not sure dose) would serve an as adequate replacement?

I found this study which would suggest this replacement for xarelto might work: A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles | Scientific Reports

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I think it’s important to say that if you’ve used nattokinase at dosages lower than at least 6000FU, please don’t share your experience because it’s not helpful and will only confuse the rest of us.

The dose we know might work is 10,800FU (probably 8000FU or higher).

At the very least, say the dose you took if you’re sharing your experience with it. Otherwise, you’re leaving out the most important information we need to know.

It’s misleading if you used 2000-4000FU and say it didn’t do anything, because the studies show you need a much higher dose for anything to happen.

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He doesn’t need nanomachines.

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Looking at birth rates in the US for 2022, there was a slight increase compared to the previous two years.

FWIW

This has been discussed in other threads

Get a PT/INR (Prothrombin Time and International Normalized Ratio) testing unit.*

They are like a glucose monitor.

Measure your PT/INR before, during and after, in as close to real time as possible.

*Locate a unit on eBay for a fraction of the cost of a “New Unit”, the testing strips are the major cost

PT/INR only applicable to certain anticoagulants. Worthless for others.

I would not depend on Aspirin and/or Natto as a replacement for Xeralto if I had a significant clotting risk.

I rarely like to use n of 1 examples, but I knew a colleague, an ER doc, who had atrial fib and decided to get by with Aspirin and vitamin E. After a couple years he had a massive stroke from a clot. Very sad.

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I don’t think it’s a good idea to replace medicines that have shown to work in large randomized controlled trials with supplements without clinically meaningful benefit, instead surrogate endpoints in small clinical trials.

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Continuing Education

StatPearls

Biochemistry, Clotting Factors

Prothrombin time/international normalized ratio

“Prothrombin time (PT) and/or International Normalized Ratio (INR) is the most commonly used coagulation assay in health care, to diagnose the risk of bleeding and to monitor oral anticoagulation therapy.”

Above posted quote from/for more details review;

PT/INR integral for management of Coumadin/Warfarin

PT/INR of no use for: Eliquis, Xeralto, Pradaxa, Lovenox, Heparin, Aspirin

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There are two effects of Nattokinase:

  1. Accelerated dissolution of blood clots : This has been verified in studies for many decades and is effective at 2000FU (might need to take it 2x a day to be effective 24 hours). Nattokinase is as effective as the expensive IV clotbusters they inject in the ER after strokes : however unless you are regularly taking 2000 FU Nattokinase, by the time you get a stroke it may take too long to absorb to kick in as rapidly as an injected clotbuster. There was a Japanese study showing, however, that IV (intravenous) Nattokinase is slightly more effective than the standard IV clotbuster t-PA.

2.Reversal of Atherosclerotic artery deposits : This is a relatively recent discovery and even Chinese studies confirm that this effect is not seen at 2000 FU/day, a slight effect occurs at 6000 FU/day but a signficant effect (30% reversal per year, comparable to Repatha) is only seen at 10800-12000 FU/day.

Note that there is no evidence that Nattokinase prevents or slows down the formation of blood clots : For this reason Nattokinase (at 2000 FU/day) is safer to take as a primary prevention for clot induced strokes and heart attacks, than prescription anti-clotting meds like Plavix (since it does NOT increase the risk of bleeding), but also less effective, since it only mitigates the damage from blood clots that get lodged in the brain (or heart). There is a lot of evidence that damage to brain from clot induced stroke is almost 100% mitigated by clot-busters administered in a timely manner, as long as the stroke is not so big as to induce loss of consciousness and injury from subsequent falls or accidents before the clot-buster effect kicks in (which takes several hours).

Supplements like Lumbrokinase and Serrapeptase may be even more effective than Nattokinase (or Repatha) at dissolving atherosclerotic plaque but come with the risk of breaking up unstable plaque, while Repatha (and other drugs that lower Apo-B significantly) will actually stabilize plaque by calcifying some of it (ironically increasing the CAC score).

I am taking Nattokinase (12000 FU/day) along with Lumbrokinase and Serrapeptase in the hope that the Nattokinase is also effective at dissolving any plaque pieces that break off and get lodged in the brain, but I have no evidence that this is the case : Nattokinase can dissolve blood clots in hours, while it takes years for Nattokinase to dissolve the primary atherosclerotic plaque. For this reason Lumbrokinase and Serrapeptase should probably not be used, if you already have significant plaque deposits, without first trying Statins + Repatha. I plan to get a CAC score and CIMT ultrasound in the near future, and if I have significant deposits, I will stop Lumbrokinase/Serrapeptase and try adding Repatha to my 10mg Lipitor.

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Thanks for the lead! I just started taking it. I usually take Neprinol in November as an annual cleanse. This year however I had PRP in rotator cuff and don’t want any fibrilytics as I’m trying to get some scar formation in the injury site. So, I appreciate the alternative.

Anyone try this brand of high dose natto? https://www.amazon.com/Davinci-Laboratories-Nattokinase-Serrapeptase-Supplement/dp/B002ONRN6A/ref=sr_1_33_sspa?crid=1JHP2UKRBWUMC&keywords=High+dose+Nattokinase&qid=1701750267&s=hpc&sprefix=high+dose+nattokinase+%2Chpc%2C149&sr=1-33-spons&sp_csd=d2lkZ2V0TmFtZT1zcF9idGY&psc=1

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FWIW

I use the following nattokinase

www.amazon.com/gp/aw/d/B0BNJKD7YC

According to the ad and packages it is manufactured in the EU/Germany and validated.

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Regarding LDL: I recently saw a robust study suggesting that higher LDL is correlated with MI ONLY for those people with CVD (as defined by a Calcium Score (CAC) > 0). There was no correlation between LDL levels and CAC = 0. This obviously means that there are other factors at work (eg insulin resistance, genetic predisposition, tendency for LDL to be oxidized, etc) besides just LDL. So I would suggest you get a Coronary Calcium score. If it’s positive you should probably be taking LOW DOSE statins (eg 5mg rosuvastatin daily). Statins do have negative side effects and you MUST take Vit K2 and CoQ10 to minimize these.
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.061010

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