I have heard a great deal from participants on this forum about the dangers of high LDL with regards to CVD and specifically atherosclerosis. Many on this forum appear to be pursuing a plant based diet (or at least an “animal meat light” diet) and many are proactively taking statins. I either started my longevity journey slower than most of you here on this forum or I’m just substantially slower, but it seems that directly targeting CV health and specifically plague formation would be a positive. That’s why I was surprised when I searched for Nattokinase in the forums and only came up with one reference to someone who is taking it (sorry for calling you out, @Dexter_Scott , but much appreciate you sharing). I’m asking this because this seems like a good addition to my “stack”.
In the below review from 2017 (written by a Chinese emergency room doctor and a natural medicine doctor from the US), they say “ Nattokinase (NK), a potent blood-clot dissolving protein used for the treatment of cardiovascular diseases, is produced by the bacterium Bacillus subtilis during the fermentation of soybeans to produce Natto. NK has been extensively studied in Japan, Korea, and China. Recently, the fibrinolytic (anti-clotting) capacity of NK has been recognized by Western medicine. The National Science Foundation in the United States has investigated and evaluated the safety of NK. NK is currently undergoing a clinical trial study (Phase II) in the USA for atherothrombotic prevention.”
(Since I haven’t heard about the results of the clinical trial perhaps it was a dud?)
Also below is a link to Amazon which suggests it is very cheap to buy (although they appear to have intentionally removed K2 so not sure what that is about).
It supposedly lowers blood pressure and a few other benefits which would be positives to longevity.
My question is: since it seems people here are concerned about longterm CVD risk enough to alter diet and take statins, Nattokinase seems to directly target CV health and plague formation, and it’s cheap, why doesn’t Nattokinase warrant even more robust discussion here? Or is this again a case of me simply being very late to a discussion which was already completed?
I’m not here to passively argue that LDL isn’t a danger to CVD, particularly over the longer scales of longevity: I’m on-board with this and looking for a way to lower my LDL. For me, my LDL has been “high” (roughly 172) for at least five years, although I had other things to worry about (cancer) so no one did anything or even flagged it before now. I’ve tried a number of diets and for me personally (due to weak will or bad breeding) I don’t feel well as a vegetarian or vegan, nor lower-protein diets (yes, even the Mediterranean diet), and the thing that seems to work best for me seems to be low carb with higher animal protein — I feel so much better on this diet (but that’s just me and I’m not selling or preaching anything). Even with 2.5 years of this diet my LDL is the same (still “high”) although all my other metabolic numbers are now excellent (TG, A1c, etc) and now my doctor says my LDL is too high. Also, with my recent (now six month) quest of trying to build real muscle (definitely working) i even tried the “carnivore diet” (cue exasperated groans) which was fine for me but didn’t appear to do anything additional (one minor thing) and didn’t raise LDL either. I’m on citrus bergamot as of March and about to test to see if it actually lowered my LDL, Ideally I’m targeting 130 LDL for a shorter-term goal, and then I’ll see where I am.
I’d prefer not to take a statin but many be I’m being idiotic as I am considering taking Nattokinase instead (which is less studied and not much cheaper).
I’d love to hear why Nattokinase hasn’t ranked high enough to make many peoples’ stacks, or at least a mention of it. Thanks.