Any news from Dr. Harold Katcher's E5 compound?

Dr. Katcher said the young exosomes in the E5 infusion were four times the volume of the old exosomes in the old rats. That’s from what I think was his most recent interview on Modern Healthspan. How that would relate to total protein, you’d know better than I.

Since they were giving multiple E5 infusions and taking blood samples fairly often, larger rat blood vessels might have made the lab work less of a chore than if they’d used mice. Maybe that’s all there was to it.

Yes, that was the interview. I’m sure its tougher, but they were able to do I.V. sEVs once a week in China.

Anyway, I’m hopeful to see some progress in this area in the coming years.

I’m always happy to see another molecule that might move the anti-aging needle. However, as I’m sure is true for everyone on this board, I’ve inevitably experienced many dissapointments. So, while I always want to hope and believe, I also developed little rules of thumb that help me gauge how much hope I should put into any one approach. Right now I’m thinking that relatively long radio semi-silence is not a super encouraging sign. If E5 was all that, I’d expect a veritable crowd of researchers rushing in to test it up the wazoo. It wouldn’t be left up to an 80 year old to hold the fort, and the occasional passerby.

I remain optimistic as always, but I’m not turning blue holding my breath wondering when the wondrous news will spring forth. As usual, YMMV.

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I am not sure there are any IP rights in E5.

So what, all the more reason for intellectually curious scientists to study a key molecule, without the encumberance of having to monetize. Universities and funded research institutions doing basic science would explore at least the physiological role of a compound, without having to address a particular medical condition. Why can’t there be papers like this, but dealing with E5:

Science seeks to broaden our understanding, not just fill our pockets with loot. Where is there “IP rights” in CR, and yet we have tens of thousands of papers and endless studies. Knowledge is its own reward, and this is motivation enough for vast numbers of scientists. What motivated Shinya Yamanaka, and countless others? Acclaim and rewards can follow, and downstream sometimes money too. Of course, scientists have to perceive a path as fruitful, if they are to expend the effort to explore, and if they don’t, we have to ask why not… maybe E5 is just not it. And there we are again.

I agree with you that the absence of IP rights does not mean that the research should not be done. IP rights make it easier to get private funding, however.

You should have a listen to this one:

@L_H put it somewhere yesterday and I was surprised by much of what was said. The E5 thing might be all due to the mitochondria. He may have stuck enough of them in there to make it work.

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Dr. Katcher has said it might be mitochondria that make E5 work. I think that’s from the same Modern Healthspan interview where he talked about volumes.

I think there is an interesting question about Xenotransplant of mitochondria.

Any further updates yet guys?

I don’t think there’s been any update.

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Modern Healthspan has been reporting on some folks in Brazil trying to replicate Mr. Katcher’s results.

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An hour long interview with the Brazilians trying to replicate Mr. Katcher’s work.

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Josh Mitteldorf wrote yesterday about “Proposal for Enhancing Experimental Anti-aging Treatment with Young Plasma” and said this:

"Large doses of young exosomes, delivered intravenously, have been shown to have extraordinary rejuvenation power in rats. We have known this for 5 years, but translation to human trials has been slow, not for technical reasons but because of trade secrets and intellectual property law and the inability to guarantee that he who funds the translation research will profit from the finished product.

In the interim, a cottage industry has developed around a weaker human therapy based on the technique that is so successful in rats. Plasma infusions are a well-developed, safe and approved procedure for trauma injury and other applications. It has been adapted by clinics in Texas as an anti-aging therapy. For some tens of thousands of dollars, an old person can buy two liters of blood plasma from a guaranteed healthy young donor.

For those with the money to spend, the limit of two liters comes about because the volume of the body’s circulatory system can be stretched only so much. Putting extra fluid into the system, with extra pressure on the arterial walls, can be dangerous. Typically, one liter of blood plasma can be removed and two added, for a net volume increase of one liter. (An adult might have 5 liters total, so this amounts to a 20% expansion of the blood volume.)

Some people report good results from this procedure, but no one has been restored to youthful appearance, health, endurance, and learning potential comparable to the rats in the laboratories of Harold Katcher or Xi Chen. I’m guessing this is because the exosome dosages in these rat experiments were far larger than the ~35% replacement that is achieved in the Texas clinics. I believe that Katcher and Chen both used exosome infusions large enough to overwhelm the reservoir of old exosomes in the blood of the old rat."

The rest of his proposal here.

From the californian plasmapheresis clinic mentioned, a " Plasmapheresis for Age Related Medical Conditions" video:

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I think E5 was piglet mitochondria which are probably more efficient than 20 year old human mitochondria

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E5 uses adolescent pig exosomes. That’s the typical age they’re slaughtered. The almost unlimited supply of, otherwise wasted, blood would produce enough E5 for everyone. However, Dr. Katcher has since said that US pigs aren’t suitable because of antibiotics given to them. He has also said that an E5 infusion requires four times the exosomes already in a person’s body. Among the things he’s trying to iron out, finding sufficient supply seems to be the biggest.

The latest Modern Healthspan touches on the supply problem very briefly. At 2:35, Richard says that Drs. Katcher and Keirstead have found ways to scale up production - the first time I’ve heard that. I don’t see where anyone has posted the video yet. It’s a general perspective on the state of the science:

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