Dr. Katcher said the young exosomes in the E5 infusion were four times the volume of the old exosomes in the old rats. That’s from what I think was his most recent interview on Modern Healthspan. How that would relate to total protein, you’d know better than I.
Since they were giving multiple E5 infusions and taking blood samples fairly often, larger rat blood vessels might have made the lab work less of a chore than if they’d used mice. Maybe that’s all there was to it.
Yes, that was the interview. I’m sure its tougher, but they were able to do I.V. sEVs once a week in China.
Anyway, I’m hopeful to see some progress in this area in the coming years.
I’m always happy to see another molecule that might move the anti-aging needle. However, as I’m sure is true for everyone on this board, I’ve inevitably experienced many dissapointments. So, while I always want to hope and believe, I also developed little rules of thumb that help me gauge how much hope I should put into any one approach. Right now I’m thinking that relatively long radio semi-silence is not a super encouraging sign. If E5 was all that, I’d expect a veritable crowd of researchers rushing in to test it up the wazoo. It wouldn’t be left up to an 80 year old to hold the fort, and the occasional passerby.
I remain optimistic as always, but I’m not turning blue holding my breath wondering when the wondrous news will spring forth. As usual, YMMV.
I am not sure there are any IP rights in E5.
So what, all the more reason for intellectually curious scientists to study a key molecule, without the encumberance of having to monetize. Universities and funded research institutions doing basic science would explore at least the physiological role of a compound, without having to address a particular medical condition. Why can’t there be papers like this, but dealing with E5:
Science seeks to broaden our understanding, not just fill our pockets with loot. Where is there “IP rights” in CR, and yet we have tens of thousands of papers and endless studies. Knowledge is its own reward, and this is motivation enough for vast numbers of scientists. What motivated Shinya Yamanaka, and countless others? Acclaim and rewards can follow, and downstream sometimes money too. Of course, scientists have to perceive a path as fruitful, if they are to expend the effort to explore, and if they don’t, we have to ask why not… maybe E5 is just not it. And there we are again.
I agree with you that the absence of IP rights does not mean that the research should not be done. IP rights make it easier to get private funding, however.
You should have a listen to this one:
@L_H put it somewhere yesterday and I was surprised by much of what was said. The E5 thing might be all due to the mitochondria. He may have stuck enough of them in there to make it work.
Dr. Katcher has said it might be mitochondria that make E5 work. I think that’s from the same Modern Healthspan interview where he talked about volumes.
I think there is an interesting question about Xenotransplant of mitochondria.