The drug rapamycin is currently the most effective and reproducible pharmacological approach for directly targeting the aging process to increase life span and health span in laboratory animals (5). Rapamycin positively impacts most hallmarks of aging, and it has been shown to increase life span in each of the major invertebrate model organisms and in rodents (4). Rapamycin increases life span by 10 to 30% in multiple strains of mice when started either early or late in life, and when administered continuously (6, 7), intermittently (8), or transiently (9).
Notably, a single 3-month treatment regimen was recently shown to increase remaining life expectancy of mice by up to 60% (9).
Not only does rapamycin treatment increase life span but it also delays, or even reverses, nearly every age-related disease or decline in function in which it has been tested in mice, rats, companion dogs, and monkeys including cancers, cardiac dysfunction, kidney disease, obesity, cognitive decline, periodontal disease, macular degeneration, muscle loss, stem cell function, and immune senescence.
Rapamycin is frequently referred to as the “Gold Standard” of anti-aging drugs because it has the highest lifespan extension effect, has worked in every animal tested, and the effectiveness has been replicated the most number of times by the greatest number of research groups.
Read the full story here: Anti-Aging Benefits of Rapamycin (part 2)