Out of curiosity, why such low dose since the suggested dosing is 30-90mg? And did you take it mornings or evenings? Thanks,
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I didn’t take it for depression. It was a bet by my doc that 10 mg would put me back to sleep after urination in the night. Works beautifully. An hour’s more sleep, instead of a battle to get back to sleep.I hardly remember having been up.
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Calcium signaling and nitric oxide are deeply intertwined in biology… but paper stays strictly on the S100A6–PARP1–cGAS-STING pathway inside cells…
Good longevity research often starts narrow (like this paper) but then expands in follow-ups or in the broader field. This study is valuable because it gives a druggable entry point (calcium homeostasis via an old, cheap drug), but it is important to understand that it is only that, “one” entry point among many.
In my opinion, the adverse effects are particularly risky for older adults. The combination of sedation, orthostatic hypotension (raising fall/fracture risk), and the rare but serious agranulocytosis makes it far from ideal for long-term use. No human data.
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Dang, I have been complaining on these board forever that I can’t sleep after I wake up to pee and not even melatonin helped me at all.
Do you take it at the time you wake up to pee, or do you take it before bed (and still helps you sleep), basically what time of day/night you take it? I desperately need to order it. Thanks,
Plus do any of you guys know if it’s available from India?
We do have a N=1 ULF in here that has taken it for over 30 years with no adverse effect. Just saying.
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OK, n = 1!
I just saw it: interesting the (super) low dose, huh…
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I was told that Mianserin is not available in India. Is anyone aware of a way to get it without a prescription somehow?
I take the Mianserin half to one hour before going to bed. It probaby helps me fall asleep I think it prevents occasional insomnia, but the main thing is that I do my peeing in the night without waking up. I have a stainless steel jug my bed, easily cleaned. In the morning it´s largely filled, from the water of the 1.2 kilos of veggies and berries that I consume in the evening before. I may be peeing up to three times a night I don´t know since I don´t remember. Once in a while I forget to take the Mianserin and my night is wrecked. When travelling it´s the one essential thing, together with my passport, to have along. I am forever indebted to the doc who was creative to think outside the box and prescribed it for me.
I get it prescribed here in Sweden. It´s commonly available as an anti-depressant and anxiolytic.
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Thak you @Ulf for the info. Glad you found something that works for you. Now, I’ll have to find a way to get my hands on some Mianserin LOL.