AGING BIOLOGY UPDATE (Newsletter from Steve Austad's group)

This is a free, periodic journal listing of articles that Steve and his group think are noteworthy:

Aging Biology Update from the UAB Nathan Shock Center600x218

Featured
Challenges in developing healthy aging trials

Naked mole-rat gene increases healthspan in mice

Contrary or Null Findings
Neither GDF11 nor GDF8 are linked to heart failure in older adults

Energetics/Nutrition
Larval diet alters fecundity-longevity relationship and gene expression in female flies

Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging

Basic Biology
Heteroplasmic mt DNA single nucleotide variants accumulate with age

Tubular lysosome induction couples animal starvation to healthy aging in C. elegans

Exposure to youthful circulation extends life and health in mice

cGAS-STING signaling drives age-related inflammation and neurodegeneration in mice

Untangling effects of anti-aging drugs and bacterial food on C. elegans using liposomes

Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis

Increased protein translation associated long-lasting negative impacts on aging in flies

Senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton

Earlier age at menopause is associated with shorter leukocyte telomere length and elevated cardiovascular risk

HIF-1 drives placental aging

Education as a key factor in longevity

Multivariate genome-wide analysis of aging-related traits

Exosomes secreted by mesenchymal stem cells delay brain aging in male accelerated aging mice

Aging impairs differentiation ability of vascular endothelial stem cells in mice

Genome-wide analysis identifies novel loci and new drug targets for healthy aging

Ether lipid biosynthesis promotes extended longevity in worms

Platelet factors enhance cognition in mice I

Platelet factors enhance cognition in mice II

A novel immune modulator controls longevity in flies

Epidemiology/Demography
Genetic variants on chromosome region 9p21.3 associated with extreme longevity in Ashkenazi

Review: Does early life adversity have adverse long-term health consequences in long-lived social mammals?

Review: Do longevity genes work by reducing hypertension?

Clinical
Improvement in cognition with lifestyle intervention in people with cognitive decline

Poor balance slows gait and increases energy cost of walking

Review: Geroscience can contribute to therapeutic strategies for older adults with cardiovascular diseases

Review: Could dietary restriction reduce periodontal disease?

Review: Hallmarks of aging in people living with HIV

Comparative Biology/Evolution
DNA methylation patterns associated with longevity in mammals

Apolipoprotein-ε4 associated with higher fecundity among the Tsimane people of Bolivia

Resting heart rate, somatic mutations and aging in mammals

Evolution of cancer-resisting and autophagy genes associated with long life in mammals

Universal DNA methylation age across mammalian tissues

Postreproductive female killer whales provide protection for male offspring

Preprint: Diet, plasma glucose, longevity and cancer prevalence across vertebrates

Review: Diverse strategies prevent cancer in large, long-lived mammals

Review: Thyroid hormones and the evolution of human longevity

Novel Organisms/Ecology
Female gray seals’ reproductive investment positively correlated with longevity

Epigenetic aging in cows is accelerated by milk production

Emerging Models
Novel primate model for the study of Alzheimer’s disease

Policy/Ethics
Geroscience and climate science: Oppositional or complementary?

Odd and Ends
Apartment-dwelling Turkish dogs shorter-lived than those living in single family homes

Does tourism contribute to healthy aging

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Aging Biology Update is brought to you by the UAB Nathan Shock Center and compiled by Kathleen Fischer, Jessica Hoffman, Heather Patterson, and Steven Austad. Subscribe to this newsletter .

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Aging Biology Update from the UAB Nathan Shock Center600x218

June 2024 ABU

Featured
Ketogenic diet induces p53-dependent cellular senescence in multiple organs in mice and serum senescence markers in people

Accumulating stochastic variation in purely simulated data is sufficient to build aging clocks

Killifish germline depletion affects wound repair and longevity in a sex-specific fashion

Basic Biology
Quantification of healthspan in aging mice: introducing FAMY and GRAIL

Sexually antagonistic effects of 16-hydroxyestriol and late-start canagliflozin on ITP mouse longevity

Epigenetic aging from a single-cell perspective

Lifelong persistence of nuclear RNAs in the mouse brain

A lipidome landscape of aging in mice

Aging atlas reveals cell-type-specific effects of worm longevity increasing genetic mutations

Mice stressed by cold (22oC) laboratory conditions have three-fold higher gut transit time than unstressed mice maintained at thermal neutral temperature (30oC)

Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling accelerates cellular aging via mitochondrial dysfunction

Energetic cost of biosynthesis: a missing link between growth and longevity in mammals?

Male-specific behavioral and transcriptomic changes in aging worm neurons

Gonadal sex, sex steroids and sex chromosomes influence mouse cardiac aging

Single-cell and single-nucleus muscle atlas of aging

Polr3b heterozygosity in mice affects health, but not lifespan, in a sex and organ specific manner

Human white matter trajectories over the lifespan

Temporal coherence of circadian metabolome across tissues disrupted in aging male mice

Human telomere length is chromosome end–specific

Review: Cause or coincidence: aging and cancer

Review: Mitophagy in aging, health and disease

Review: Alterations of the blood-brain barrier during aging

Review: Replication stress in cellular senescence and aging

Contrary or Null Findings
Dietary restriction fails to extend lifespan of Drosophila model of Werner syndrome

Elders (> 80) with broken wrists have a lower mortality rate than age- and gender-matched controls

RCT finds no impact on grip strength of increased protein intake in older adults in a 12-week trial

Senolytic treatment fails to prevent cognitive decline in a female F344 rats

Few relationships between alcohol use and brain macrostructure found in older (70-90) low-level drinkers

Review: Deprescribing interventions have no significant impact on reducing Drug Burden Index or improving outcomes

Energetics/Nutrition
Counting steps instead of counting minutes for healthy longevity

Diet correlated with DunedinPACE epigenetic clock age and risk of dementia

Food insecurity and epigenetic aging in middle-aged and older adults

Time-restricted feeding improves aortic endothelial relaxation in aged mice

Complex lipid signature marks human muscle aging and responds to short-term exercise

Review: Amino acid restriction, aging, and longevity

Opinion. Adipose tissue as a linchpin of organismal ageing

Epidemiology/Demography
Infertility associated with incidence of postmenopausal breast cancer largely through age at first term pregnancy

Association of race, ethnicity, and socioeconomic status on the severity of menopause symptoms

Pregnancy complications associated with higher mortality risk >40 years later

Physical and cognitive function — not age — are key predictors of heat-related mortality

Systolic blood pressure <130 associated with longevity in older women

Traditional Mexican diet associated with lower cancer risk among women of Mexican descent

Unique microRNAs associated with exceptional longevity

Development and validation of an intrinsic capacity score in the UK Biobank study

Can retirement be deadly: a demographic analysis

Transition from low-to-high or high-to-low SES impacts dementia risk more than stable SES category

Reduced childhood mortality correlated with extended maternal lifespan

Global Burden of Disease study details greater morbidity for women across the life course, greater mortality for men

Edible cannabis legalization associated with significantly increased cannabis poisoning in older Canadian adults

Preprint: Quantifying individual- and population-level differences in rate of aging-related health declines

Clinical
Health advice for postmenopausal women from the Women’s Health Initiative trials

Female and male Medicare patients have lower patient mortality when treated by female physicians

Antipsychotics use in people with dementia associated with greater risk of adverse outcomes than expected

Geriatric depression: what clinicians need to know

Predictors of mortality shortly after entering a long-term care facility

Auditory processing but not peripheral hearing differs in older adults with and without mild cognitive impairment

Menopause depression: Under recognized and poorly treated

Review: Clinical challenges in the treatment of hypertension among aging adults

Review: Association of chronic pain with dementia

Review: Prognostic value of clinical assessments for older people

Evolution/Comparative
Are brain size and fidelity of double strand-break repair coevolving?

Selection for longer life and sex-specific reproductive costs in a 20th century population

Does effective population size govern evolutionary differences in telomere length?

Naked mole-rat mortality rates do not increase with age

Reproduction and post-reproductive lifespan in honeybee workers

Review: Extreme longevity: evolutionary implications

Review: Comparing species responses to putative life-extending pharmacological interventions

Perspective: Costs and benefits of molecular turnover with respect to health and aging

Novel Organisms
Nice Japanese quail have longer telomeres and longer lives than nasty quail

Telomere length is longer following diapause in two solitary bee species

Maternal age effects on offspring lifespan and reproduction among rotifers

Meeting abstract: Enhanced DNA damage response in Myotis bats

Caregiving
Parental health disproportionately affects female employment in China

Resource: Online tool to help manage neuropsychiatric symptoms of dementia

Policy/Ethics
Universal palliative care for healthy longevity

Changes in Medicare/Medicaid coverage could cost thousands of lives without saving as much money as expected

Caregivers, unseen, un- or underpaid and overwhelmed

Telehealth expansion increases clinical encounters but may not improve outcomes

Caring for an aging US population

Commentary
The lifespan-healthspan gap Is the greatest health challenge of the 21st century

Should the social “exposome” be incorporated into geroscience research?

Agent-based modeling: a tool to overcome some limits of randomized control trials

What frailty can tell us about aging well

Where angels fear: the complexity of cellular senescence

Odd and Ends
Does geroscience have a white hat bias problem?

People who visit senior centers are more likely to get regular health check-ups

1st known cancer treatment discovered on 4600-year-old Egyptian skull

Medicalization of old age

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Aging Biology Update is brought to you by the UAB Nathan Shock Center and compiled by Kathleen Fischer and Steven Austad

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Web Version
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Aging Biology Update from the UAB Nathan Shock Center600x218

February 2025 ABU

Featured
Mommy dearest: Active maternal X chromosome impairs cognition and accelerates brain aging in female mice

Basic Biology
C57BL/6 sub-strain differences in aging-related behaviors

Differentiation of human iPSCs into Leydig-like cells with long-term stable secretion of testosterone

Aging of ovarian blood vessels implicated in mid-life fertility decline in mice

This old mouse: Exosomal micro-RNA reverses proliferative arrest of senescent cells and rejuvenates aging mice

Accumulation of autophagosomes in aging human photoreceptor cell synapses

Reduced mTOR signaling reduces protein aggregation during heat stress and aging in yeast

Key pathways and hub genes altered by aging and caloric restriction in rat muscle

Menopause-induced 17β-estradiol and progesterone loss increases senescence markers and degeneration in middle-aged mouse cartilage

Mutation accumulation drives long, slow death of neurons in Huntington’s disease

Molecular responses to heat stroke differ in an age-specific pattern

Age is correlated with a global decline in splicing fidelity across human introns

Prediction of healthy aging and age-related diseases in late middle-aged Chinese adults using blood protein biomarkers

The “androgen clock” is an epigenetic predictor of long-term male hormone exposure in mice and sheep

Resource: A physical exercise-regulated differential gene expression database

Review: What can single-cell omics teach us about brain aging and rejuvenation?

Review: Could macrophage inflammation be beneficial for enhancing regrowth of aging muscle?

Review: Biological sex matters in brain aging

Review: DNA damage and its links to neuronal aging and degeneration

Review: What we can learn about osteoporosis from human accelerated aging paradigms

Review: The pathobiology of neurovascular aging

Review: Statistical and computational challenges in use of epigenetic clocks

Review: Circadian clock communication during homeostasis and aging

Clinical
Healthy lifestyle slows late life cognitive decline regardless of genetic susceptibility

Early menopause associated with development of type 2 diabetes

Benefits generally outweigh risks of GLP-1 receptor agonists in men

RSV vaccination effective in preventing RSV-related illness in older (>60 yo) men

Aging and inflammation limit immune response in severe COVID-19

Overtreatment of prostate cancer among men with limited longevity?

Supporting healthy aging for people with intellectual disabilities in group homes

Review: Medical implications of sex differences in immunometabolism

Review: Pain assessment of people with dementia living in nursing homes

Review: Pharmacodynamics and pharmacokinetics of chronically administered medicines in older adults

Review: Aging with HIV

Review: A systems approach to functional aging

Epidemiology/Demography
ADHD associated with shorter lifespans

Ten-question assessment of biomedical dataset quality and trustworthiness

Unique methylome of long-lived men

Weak handgrip strength and slow timed up-and-go independently associated with increased hospitalization costs

Number of children and dementia risk

Life expectancy gap as a function of educational attainment continues to increase

Alzheimer’s and related dementias among Medicare beneficiaries aged ≥ 65 years in rural America

Adult physical activity and all-cause mortality; a prospective twin study

Impaired chewing capacity associated with accelerated aging and higher mortality risk

Seasonality in mortality and its impact on life expectancy levels and trends across Europe

Infertility is associated with clear cell and endometrioid ovarian cancer but not other ovarian tumor types

Energetics/Nutrition
Pharmacological reduction of lipid hydroperoxides preserves muscle function in aged female mice

Degree of food processing associated with all-cause and cause-specific mortality

Association of cardiovascular fitness, age, and sex with adult cortical thickness and gray matter

Skeletal muscle metabolic response to contraction is age- and sex-dependent

Review: Characterizing the effects of dietary protein on health across the lifespan

Review: Caloric restriction in heart failure with preserved ejection fraction

Review: The role of mitochondria in repurposed diabetes drugs for off-label health benefits

Evolution/Comparative Biology
How flight helped bats become resistant to viruses

Island population of snake-eyed skinks mature earlier and live longer than a mainland population

Maternal effect senescence and caloric restriction interact to affect lifespan and fitness via life history timing in a rotifer

Evolutionary history and role of reactive oxygen species in regeneration

Female reproductive aging in chacma baboons and geladas

Evolution of host-microbiome/holobiont symbionts, host lifespan and host fecundity

Review: Age estimation methods in non-avian reptiles

Novel Organisms
XY females exhibit more rapid reproductive senescence than XX or XX females in African pygmy mice

Tree shrew: a new animal model for musculoskeletal disorders and aging?

Zebrafish model of Werner syndrome identifies a potential antiaging drug

Caregiving
Providing end-of-life care support is associated with higher end-of-life health literacy

Caught between kids and ill older family members, caregivers experience physical and mental health declines

Small study identifies needs of young caregivers whose parent has dementia

Review: Interventions to prevent and respond to abuse of older people

Methodologies
Cage effects and how to analyze them in mouse frailty studies

A tool to detect inaccurate self-reported energy intake

Policy
Tempo Braggadocio: Self-promotion increases probability of biomedical grant funding

Homecare yields greatest systemwide cost savings among community-dwelling older adult

Residential greenness is associated with epigenetic aging in adults

Telemedicine for people covered by Medicare may be dropped

Review: Telemedicine solutions may significantly improve waiting times

Commentary
Balancing the promise and risks of geroscience interventions

Deep learning and generative artificial intelligence in aging research and healthy longevity medicine

Resources for recognizing predatory journals

The British Geriatrics Society’s position on assisted dying

A new science of menopause?

Clinical practice in an age of medical misinformation and conspiracy theories

NIA Resource Centers for Minority Aging Research: Development, evolution, and impact

Odds and Ends
Death, where is thy sting?

Review: Age-friendly cities

Review: Epigenetics and individuality

Contrary/Null Results
Heterochronic microbiome transplants fail to increase longevity in fruit flies

No significant differences between a health system–based vs a community-based care intervention nor between either active intervention vs a usual care control group in patient behavior and caregiver strain

Geriatrics-focused primary care did not increase time measures of self-reported health or integration of care within the first 18 months in the VA Health Care System

Self-reported traumatic brain injury fails to predict Alzheimer’s disease neuropathology and dementia

Klotho mutation fails to accelerate intervertebral disc aging in 8-week-old mice

Scant evidence of benefit from “senior-friendly” hospitals

Announcements
Is this position for you? Section Chief, Comparative Medicine

Conference: Human Dietary Protein Needs and Benefits: A Critical Assessment of Postulated Propositions, February 25, 2025 – February 26, 2025

Nathan Shock Center Pilot Awards: Active RFAs
Albert Einstein College of Medicine Nathan Shock Center 2024 Pilot & Feasibility Project Awards for Core Use Rolling Deadline

USC-Buck Nathan Shock Center Pilot Awards Rolling Deadline

San Antonio Nathan Shock Center Pilot Project Grants Deadline: February 15, 2025

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Aging Biology Update is brought to you by the UAB Nathan Shock Center and compiled by Kathleen Fischer and Steven Austad. Subscribe to this newsletter.