June 2024 ABU
Featured
Ketogenic diet induces p53-dependent cellular senescence in multiple organs in mice and serum senescence markers in people
Accumulating stochastic variation in purely simulated data is sufficient to build aging clocks
Killifish germline depletion affects wound repair and longevity in a sex-specific fashion
Basic Biology
Quantification of healthspan in aging mice: introducing FAMY and GRAIL
Sexually antagonistic effects of 16-hydroxyestriol and late-start canagliflozin on ITP mouse longevity
Epigenetic aging from a single-cell perspective
Lifelong persistence of nuclear RNAs in the mouse brain
A lipidome landscape of aging in mice
Aging atlas reveals cell-type-specific effects of worm longevity increasing genetic mutations
Mice stressed by cold (22oC) laboratory conditions have three-fold higher gut transit time than unstressed mice maintained at thermal neutral temperature (30oC)
Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling accelerates cellular aging via mitochondrial dysfunction
Energetic cost of biosynthesis: a missing link between growth and longevity in mammals?
Male-specific behavioral and transcriptomic changes in aging worm neurons
Gonadal sex, sex steroids and sex chromosomes influence mouse cardiac aging
Single-cell and single-nucleus muscle atlas of aging
Polr3b heterozygosity in mice affects health, but not lifespan, in a sex and organ specific manner
Human white matter trajectories over the lifespan
Temporal coherence of circadian metabolome across tissues disrupted in aging male mice
Human telomere length is chromosome endāspecific
Review: Cause or coincidence: aging and cancer
Review: Mitophagy in aging, health and disease
Review: Alterations of the blood-brain barrier during aging
Review: Replication stress in cellular senescence and aging
Contrary or Null Findings
Dietary restriction fails to extend lifespan of Drosophila model of Werner syndrome
Elders (> 80) with broken wrists have a lower mortality rate than age- and gender-matched controls
RCT finds no impact on grip strength of increased protein intake in older adults in a 12-week trial
Senolytic treatment fails to prevent cognitive decline in a female F344 rats
Few relationships between alcohol use and brain macrostructure found in older (70-90) low-level drinkers
Review: Deprescribing interventions have no significant impact on reducing Drug Burden Index or improving outcomes
Energetics/Nutrition
Counting steps instead of counting minutes for healthy longevity
Diet correlated with DunedinPACE epigenetic clock age and risk of dementia
Food insecurity and epigenetic aging in middle-aged and older adults
Time-restricted feeding improves aortic endothelial relaxation in aged mice
Complex lipid signature marks human muscle aging and responds to short-term exercise
Review: Amino acid restriction, aging, and longevity
Opinion. Adipose tissue as a linchpin of organismal ageing
Epidemiology/Demography
Infertility associated with incidence of postmenopausal breast cancer largely through age at first term pregnancy
Association of race, ethnicity, and socioeconomic status on the severity of menopause symptoms
Pregnancy complications associated with higher mortality risk >40 years later
Physical and cognitive function ā not age ā are key predictors of heat-related mortality
Systolic blood pressure <130 associated with longevity in older women
Traditional Mexican diet associated with lower cancer risk among women of Mexican descent
Unique microRNAs associated with exceptional longevity
Development and validation of an intrinsic capacity score in the UK Biobank study
Can retirement be deadly: a demographic analysis
Transition from low-to-high or high-to-low SES impacts dementia risk more than stable SES category
Reduced childhood mortality correlated with extended maternal lifespan
Global Burden of Disease study details greater morbidity for women across the life course, greater mortality for men
Edible cannabis legalization associated with significantly increased cannabis poisoning in older Canadian adults
Preprint: Quantifying individual- and population-level differences in rate of aging-related health declines
Clinical
Health advice for postmenopausal women from the Womenās Health Initiative trials
Female and male Medicare patients have lower patient mortality when treated by female physicians
Antipsychotics use in people with dementia associated with greater risk of adverse outcomes than expected
Geriatric depression: what clinicians need to know
Predictors of mortality shortly after entering a long-term care facility
Auditory processing but not peripheral hearing differs in older adults with and without mild cognitive impairment
Menopause depression: Under recognized and poorly treated
Review: Clinical challenges in the treatment of hypertension among aging adults
Review: Association of chronic pain with dementia
Review: Prognostic value of clinical assessments for older people
Evolution/Comparative
Are brain size and fidelity of double strand-break repair coevolving?
Selection for longer life and sex-specific reproductive costs in a 20th century population
Does effective population size govern evolutionary differences in telomere length?
Naked mole-rat mortality rates do not increase with age
Reproduction and post-reproductive lifespan in honeybee workers
Review: Extreme longevity: evolutionary implications
Review: Comparing species responses to putative life-extending pharmacological interventions
Perspective: Costs and benefits of molecular turnover with respect to health and aging
Novel Organisms
Nice Japanese quail have longer telomeres and longer lives than nasty quail
Telomere length is longer following diapause in two solitary bee species
Maternal age effects on offspring lifespan and reproduction among rotifers
Meeting abstract: Enhanced DNA damage response in Myotis bats
Caregiving
Parental health disproportionately affects female employment in China
Resource: Online tool to help manage neuropsychiatric symptoms of dementia
Policy/Ethics
Universal palliative care for healthy longevity
Changes in Medicare/Medicaid coverage could cost thousands of lives without saving as much money as expected
Caregivers, unseen, un- or underpaid and overwhelmed
Telehealth expansion increases clinical encounters but may not improve outcomes
Caring for an aging US population
Commentary
The lifespan-healthspan gap Is the greatest health challenge of the 21st century
Should the social āexposomeā be incorporated into geroscience research?
Agent-based modeling: a tool to overcome some limits of randomized control trials
What frailty can tell us about aging well
Where angels fear: the complexity of cellular senescence
Odd and Ends
Does geroscience have a white hat bias problem?
People who visit senior centers are more likely to get regular health check-ups
1st known cancer treatment discovered on 4600-year-old Egyptian skull
Medicalization of old age
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Aging Biology Update is brought to you by the UAB Nathan Shock Center and compiled by Kathleen Fischer and Steven Austad
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Web Version
February 2025 ABU
Featured
Mommy dearest: Active maternal X chromosome impairs cognition and accelerates brain aging in female mice
Basic Biology
C57BL/6 sub-strain differences in aging-related behaviors
Differentiation of human iPSCs into Leydig-like cells with long-term stable secretion of testosterone
Aging of ovarian blood vessels implicated in mid-life fertility decline in mice
This old mouse: Exosomal micro-RNA reverses proliferative arrest of senescent cells and rejuvenates aging mice
Accumulation of autophagosomes in aging human photoreceptor cell synapses
Reduced mTOR signaling reduces protein aggregation during heat stress and aging in yeast
Key pathways and hub genes altered by aging and caloric restriction in rat muscle
Menopause-induced 17Ī²-estradiol and progesterone loss increases senescence markers and degeneration in middle-aged mouse cartilage
Mutation accumulation drives long, slow death of neurons in Huntingtonās disease
Molecular responses to heat stroke differ in an age-specific pattern
Age is correlated with a global decline in splicing fidelity across human introns
Prediction of healthy aging and age-related diseases in late middle-aged Chinese adults using blood protein biomarkers
The āandrogen clockā is an epigenetic predictor of long-term male hormone exposure in mice and sheep
Resource: A physical exercise-regulated differential gene expression database
Review: What can single-cell omics teach us about brain aging and rejuvenation?
Review: Could macrophage inflammation be beneficial for enhancing regrowth of aging muscle?
Review: Biological sex matters in brain aging
Review: DNA damage and its links to neuronal aging and degeneration
Review: What we can learn about osteoporosis from human accelerated aging paradigms
Review: The pathobiology of neurovascular aging
Review: Statistical and computational challenges in use of epigenetic clocks
Review: Circadian clock communication during homeostasis and aging
Clinical
Healthy lifestyle slows late life cognitive decline regardless of genetic susceptibility
Early menopause associated with development of type 2 diabetes
Benefits generally outweigh risks of GLP-1 receptor agonists in men
RSV vaccination effective in preventing RSV-related illness in older (>60 yo) men
Aging and inflammation limit immune response in severe COVID-19
Overtreatment of prostate cancer among men with limited longevity?
Supporting healthy aging for people with intellectual disabilities in group homes
Review: Medical implications of sex differences in immunometabolism
Review: Pain assessment of people with dementia living in nursing homes
Review: Pharmacodynamics and pharmacokinetics of chronically administered medicines in older adults
Review: Aging with HIV
Review: A systems approach to functional aging
Epidemiology/Demography
ADHD associated with shorter lifespans
Ten-question assessment of biomedical dataset quality and trustworthiness
Unique methylome of long-lived men
Weak handgrip strength and slow timed up-and-go independently associated with increased hospitalization costs
Number of children and dementia risk
Life expectancy gap as a function of educational attainment continues to increase
Alzheimerās and related dementias among Medicare beneficiaries aged ā„ 65 years in rural America
Adult physical activity and all-cause mortality; a prospective twin study
Impaired chewing capacity associated with accelerated aging and higher mortality risk
Seasonality in mortality and its impact on life expectancy levels and trends across Europe
Infertility is associated with clear cell and endometrioid ovarian cancer but not other ovarian tumor types
Energetics/Nutrition
Pharmacological reduction of lipid hydroperoxides preserves muscle function in aged female mice
Degree of food processing associated with all-cause and cause-specific mortality
Association of cardiovascular fitness, age, and sex with adult cortical thickness and gray matter
Skeletal muscle metabolic response to contraction is age- and sex-dependent
Review: Characterizing the effects of dietary protein on health across the lifespan
Review: Caloric restriction in heart failure with preserved ejection fraction
Review: The role of mitochondria in repurposed diabetes drugs for off-label health benefits
Evolution/Comparative Biology
How flight helped bats become resistant to viruses
Island population of snake-eyed skinks mature earlier and live longer than a mainland population
Maternal effect senescence and caloric restriction interact to affect lifespan and fitness via life history timing in a rotifer
Evolutionary history and role of reactive oxygen species in regeneration
Female reproductive aging in chacma baboons and geladas
Evolution of host-microbiome/holobiont symbionts, host lifespan and host fecundity
Review: Age estimation methods in non-avian reptiles
Novel Organisms
XY females exhibit more rapid reproductive senescence than XX or XX females in African pygmy mice
Tree shrew: a new animal model for musculoskeletal disorders and aging?
Zebrafish model of Werner syndrome identifies a potential antiaging drug
Caregiving
Providing end-of-life care support is associated with higher end-of-life health literacy
Caught between kids and ill older family members, caregivers experience physical and mental health declines
Small study identifies needs of young caregivers whose parent has dementia
Review: Interventions to prevent and respond to abuse of older people
Methodologies
Cage effects and how to analyze them in mouse frailty studies
A tool to detect inaccurate self-reported energy intake
Policy
Tempo Braggadocio: Self-promotion increases probability of biomedical grant funding
Homecare yields greatest systemwide cost savings among community-dwelling older adult
Residential greenness is associated with epigenetic aging in adults
Telemedicine for people covered by Medicare may be dropped
Review: Telemedicine solutions may significantly improve waiting times
Commentary
Balancing the promise and risks of geroscience interventions
Deep learning and generative artificial intelligence in aging research and healthy longevity medicine
Resources for recognizing predatory journals
The British Geriatrics Societyās position on assisted dying
A new science of menopause?
Clinical practice in an age of medical misinformation and conspiracy theories
NIA Resource Centers for Minority Aging Research: Development, evolution, and impact
Odds and Ends
Death, where is thy sting?
Review: Age-friendly cities
Review: Epigenetics and individuality
Contrary/Null Results
Heterochronic microbiome transplants fail to increase longevity in fruit flies
No significant differences between a health systemābased vs a community-based care intervention nor between either active intervention vs a usual care control group in patient behavior and caregiver strain
Geriatrics-focused primary care did not increase time measures of self-reported health or integration of care within the first 18 months in the VA Health Care System
Self-reported traumatic brain injury fails to predict Alzheimerās disease neuropathology and dementia
Klotho mutation fails to accelerate intervertebral disc aging in 8-week-old mice
Scant evidence of benefit from āsenior-friendlyā hospitals
Announcements
Is this position for you? Section Chief, Comparative Medicine
Conference: Human Dietary Protein Needs and Benefits: A Critical Assessment of Postulated Propositions, February 25, 2025 ā February 26, 2025
Nathan Shock Center Pilot Awards: Active RFAs
Albert Einstein College of Medicine Nathan Shock Center 2024 Pilot & Feasibility Project Awards for Core Use Rolling Deadline
USC-Buck Nathan Shock Center Pilot Awards Rolling Deadline
San Antonio Nathan Shock Center Pilot Project Grants Deadline: February 15, 2025
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Aging Biology Update is brought to you by the UAB Nathan Shock Center and compiled by Kathleen Fischer and Steven Austad. Subscribe to this newsletter.
Thank you RapAdmin, thatās a great resource. I might be hallucinating, but I seem to recall that this newsletter was mentioned in the recent Peter Attia roundtable podcast featuring Rich Miller, Matt Kaeberlein and Steve. In any case, well worth subscribing to.
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Web Version
April 2025 ABU
Featured
New mechanisms of blood-brain barrier disruption in aging mice
Rare IGF-1 coding variants with reduced IGF-1 activity identified in exceptionally long-lived humans
Basic Biology
Sex-specific decline in prefrontal cortex mitochondrial bioenergetics in aging baboons correlates with walking speed
Ganoderic acid A identified as a senotherapeutic via ribosomal homeostasis in worms and mice
Aged female laboratory mice did not display the profound loss of clonal diversity characteristic of human hematopoietic aging
Senolytics attenuate dysfunction of the aging brain of male but not female C57BL/6N mice
Reduced removal of waste products from energy metabolism implicated in human brain aging
Spermine alleviates doxorubicin-induced myocardial cell damage by inhibiting oxidative stress in rats
SIRT5 slows primate skeletal muscle ageing by alleviating inflammation
Is midlife a critical period for metabolic intervention in brain aging?
FOXM1 expression alters aging chromatin profiles in primary dermal fibroblasts
Cytokine surge in blood precedes cancer diagnosis in people >80 years
Social disadvantage accelerates proteomic signatures of aging
Review: Sex-specific mechanisms in vascular aging of mice and humans
Review: Time-of-day effects crucial for improving reproducibility and translation of metabolism research
Clinical
Adrenal cortex senescence: an ageing-related pathology?
Low score on multiple DNA methylation clocks associated with better physical function in oldest-old living in Singapore
Anti-retroviral therapy clinical trial for Alzheimerās disease
Gait changes with aging: an early warning sign for underlying pathology
COVID-19 booster makes male antibody responses comparable to females in nursing home residents
Age and cognitive skills: Use it or lose it?
Quick as a stick? A frailty metric based on plasma CRP, hemoglobin, albumin and vitamin D
Review: Examining the role of physical exercise to counteract cognitive aging
Contrary/Null Results
Cocoa flavanol supplement has no effect on occurrence or progression of age-related macular degeneration
Unmarried individuals may have a lower risk of dementia compared to married adults
Epigenetic age is not correlated with physical performance in aging captive baboons
Meta-analysis: No sex differences in the efficacy of treatments for Type 2 diabetes
RCT: Computerized-brain-training improves performance at computerized brain training
RCT: Multivitamins do not reduce cardiovascular events in people with chronic coronary disease, diabetes, and a previous MI
RCT: Little evidence of efficacy in social network intervention to address loneliness and social isolation
RCT: Metformin did not improve physical performance in frail or prefrail people
Epidemiology/Demography
Urban dwellers age more successfully than rural dwellers in China too
Proteomic organ-specific aging signatures and 20-year risk of age-related diseases
Sex differences in Apolipoprotein E and Alzheimer disease pathology across ethnicities
Disability-free life expectancy is a decade shorter in disadvantaged areas of England
Can patterns of medication use predict age-related neurodegenerative diseases?
Iron deficiency anemia-related mortality in older people increased from 2013 to 2019
Energetics/Nutrition
Surprise! 30 years of follow-up finds veggies good, fat and sugar bad, for healthy longevity
RCT: Daily protein-enriched lacto-vegetarian soup supplementation enhanced physical performance and functional assessments among older adults at risk of malnutrition and sarcopenia
Age, sex, and mitochondrial-haplotype influence rat gut microbiome composition and metabolites
Age-associated decline of host-microbiome metabolic interactions in male mice
Review: Health implications of meat-based diets
Evolution/Comparative Biology
Biological age based on common clinical values in cats, dogs, and humans predict mortality risk in dogs
Reproductive tradeoff with longevity over four centuries in Spanish women
Gene copy number in cancer-related pathways associated with cancer prevalence, but not longevity, in mammals
Novel Organisms
Long-term resveratrol supplementation provides health benefits to middle-age male mouse lemurs but has limited long-term effects on health and longevity
Genome assembly of Arctica islandica, the longest lived non-colonial animal species
Can adaptation to hypoxia explain the blind mole-ratās longevity and cancer resistance?
Caregiving
Do Europeans really feel better at home than in a nursing home? Itās complicated
Who receives informal care: the role of multimorbidity and social position
Policy
Policy ideas to address U.S. rural population health in the 2020ās
HHS proposes to eliminate notice and public comment on agency management, personnel, public property, loans, grants, benefits, and contracts and comment procedures of 5 U.S.C. 553, except as otherwise required by law
Methodology
Cities, communities and clinics can be testbeds for human exposome and aging research
Commentary
Postdocs and PhD students hit hard by sudden changes in US science funding
US PhD admissions decline in response to science funding cuts
Lysosomal stress for healthy aging
Announcements
The 2025 AFAR Vincent Cristofalo, George M. Martin, and Irving S. Wright AFAR Scientific Awards of Distinction
AGE 53rd Annual Meeting: New Frontiers in Aging Research, May 11-14, 2025 AnchorAGE, Alaska USA
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Aging Biology Update is brought to you by the UAB Nathan Shock Center and compiled by Kathleen Fischer and Steven Austad. Subscribe to this newsletter.
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Itās a good newsletter, Iām subscribed. Highly recommended.
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May 2025 ABU
Featured
Sex-, cell-type- and tissue-specific changes in chaperone-mediated autophagy during mouse aging
German longevity study reveals rare pro-longevity alleles in mTOR signaling network
Basic Biology
Brazilians living in endemic infectious disease areas show accelerated epigenetic aging and greater inflammation than those living in control areas
Mitochondrial dysfunction promotes mTORC1-dependent skeletal aging
Sirt2 deficiency aggravates intramuscular adipose tissue infiltration and impairs myogenesis with aging in male mice
Lifelong muscle-specific PGC-1Ī± overexpression exacerbates declines in mitochondrial biomarkers in the aging male mouse hippocampus
A computational framework for assessing inter-tissue molecular coordination associated with aging
Human pluripotent stem cell-derived neurons engineered to evade the immune system ameliorate motor symptoms in a rat model of Parkinsonās disease
Human skeletal muscle disuse atrophy negatively affects the muscle metabolome and lipidome
Results in dogs align with human age-related immune and metabolic alterations
Review: Promoting health and survival through lowered body temperature
Review: Marine algae: a source of anti-aging compounds?
Clinical
A hospital-based special care unit for dementia improved outcomes across medical wards
Translational genomics of osteoarthritis
Can AI improve cliniciansā diagnostic reasoning and accuracy in challenging cases?
Utility of frailty assessment in emergency departments
Mechanism by which attenuating mTORC1 signaling may boost vaccine responses in older individuals
Orthostatic hypotension symptoms and drugs affecting autonomic function increase odds of frailty in people > 80
Weāre shocked, shocked: Wealthy people live longer in the US and Europe
Op-ed: Reframing sarcopenia and frailty
Review: Enhancing immunity during aging by targeting interactions within the tissue environment
Epidemiology/Demography
Cohort life expectancy in the South, especially among females, changed little for those born between 1900 and 2000
Health follows wealth: Swedes from higher income groups adopt healthy lifestyle habits faster, helping explain their greater gain in life expectancy
Influenza vaccination rates increased among older Black and Hispanic adults and decreased among rural , poorly educated Whites during COVID-19 pandemic
Identifying and modeling disease interactions to understand mortality risk in patients with chronic heart disease
Immune resilience critical to healthy aging
Alzheimerās disease subtypes show sex-specific differences in disease progression
One year of low-dose, intermittent rapamycin is relatively safe in healthy adults and was associated with improvements in lean tissue mass and pain in women
APOE variants have somewhat different dementia risk profiles among Hispanics/Latinos from different countries
Having a spouse to confide in reduces mortality in older adults
People living in rural areas within a state that has not expanded Medicaid report worse health
Energetics/Nutrition
Distinct adipose progenitor cells drive age-associated expansion of visceral adipose tissue in mice
Dietary restriction does not rejuvenate the microbiome and other findings in genetically diverse mice
Low methionine diet started at 18 months, improved mouse health without affecting an epigenetic clock
Not everything is better with butter: butter and plant-based oils intake and mortality
Periodic exclusion of animal products induces metabolic reprogramming in humans
A gut hormone affects food choice and lifespan in mated female flies
RCT: Three-month study finds pomegranate extract improves inflammation cardiometabolic risk factors in older adults?
Higher coffee consumption found to be associated with decreased frailty
Review: Potential drawbacks to caloric restriction
Contrary or Null Findings
Neither environmental- or socioeconomic burden significantly influenced the impact of extreme exposures to heat and PM2.5 on mortality in California
No evidence for a trade-off between reproduction and survival in a meta-analysis across birds
Drug decriminalization did not change drug-related fatal traffic crashes in Oregon
DNA methylation patterns are not associated with age in Daphnia magna
Evolution/Comparative
Grandmother effect revisited twenty-two years later
Variable gene copy number in cancer-related pathways is associated with cancer prevalence, but not longevity, in mammals
Killifish species show better association between brain gene expression profiles and life history traits than liver gene expression profiles
Review: Mitochondria as a regulator of cellular oxidative homeostasis
Review: The Hippo pathway: a molecular bridge between environmental cues and pace of life?
Review: Aging, metabolomics, and paleoanthropology
Review: Why some hearts heal, and others donāt
Novel Organisms
Sex-specific effects of Wolbachia infection on lifespan, egg size and development in azuki bean beetles
DNA methylation dynamics consistent with sex and status differences in polygynous spear-nosed bat mortality rates
Mortality and life table analysis in a cohort of pet cats (> 9 years old) in the UK
Review: Water loss and dog aging
Caregiving
Forecasting informal family caregiving burden in Europe, 2000-2050
Barriers to dying in the community in England
Nature nurtures older people in assisted living facilities
Needs of people caring for people with dementia
Animal-assisted activities mitigate loneliness in older adults
Review: Burdens and benefits of caregiving for older adults
Policy/Ethics
Medicaid prescription denials may result in higher overall healthcare costs
Purge of U.S. health agency leaders and others eviscerates NIH
āWholesale assault on U.S. scienceā
Commentary
Type 2 diabetes and accelerated aging in skeletal muscle
Autophagy does not always decline with aging
Can metformin actually slow the aging process?
The costs of standing still: NIH funding stagnant since 2003
Increasing out-of-pocket drug spending despite declining net drug prices
Veteransā Affairs research jeopardized
International PhD students make emergency plans in fear of US immigration raids
Scienceās big problem is a loss of influence, not a loss of trust
Now is not the time for despair
The pattern of research cuts at the NIH
Odd and Ends
Motherhood at 100āwho says you canāt teach an old tortoise new tricks?
Taming transposons to treat aging?
How Europe aims to woo US scientists and protect academic freedom
75% of US scientists who answered Nature poll consider leaving
Financial literacy in older adults associated with vocabulary knowledge and semantic memory independent of education level
Mine! Mine, Mine, Mine!!! AlphaFold is running out of data ā so drug firms are building their own proprietary version
Tariffs hit science labs through increasing supply costs
Should Mpox be squirrel pox (Spox)?
154 million lives and counting
Adult age differences in the integration of values for self and other
Announcements
Applications Open: Statistical Methods, Developments, and Challenges in Geroscience Meeting, June 16-18, Indianapolis.
RCCN Workshop: AI and Health Behaviors in Healthy Aging (Virtual). June 24-25. Register here.
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Aging Biology Update is brought to you by the UAB Nathan Shock Center and compiled by Kathleen Fischer, Heather Patterson, and Steven Austad. Subscribe to this newsletter.
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