AGING BIOLOGY UPDATE (Newsletter from Steve Austad's group)

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This is a free, periodic journal listing of articles that Steve and his group think are noteworthy:

Featured
Challenges in developing healthy aging trials

Naked mole-rat gene increases healthspan in mice

Contrary or Null Findings
Neither GDF11 nor GDF8 are linked to heart failure in older adults

Energetics/Nutrition
Larval diet alters fecundity-longevity relationship and gene expression in female flies

Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging

Basic Biology
Heteroplasmic mt DNA single nucleotide variants accumulate with age

Tubular lysosome induction couples animal starvation to healthy aging in C. elegans

Exposure to youthful circulation extends life and health in mice

cGAS-STING signaling drives age-related inflammation and neurodegeneration in mice

Untangling effects of anti-aging drugs and bacterial food on C. elegans using liposomes

Retrotransposons hijack alt-EJ for DNA replication and eccDNA biogenesis

Increased protein translation associated long-lasting negative impacts on aging in flies

Senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton

Earlier age at menopause is associated with shorter leukocyte telomere length and elevated cardiovascular risk

HIF-1 drives placental aging

Education as a key factor in longevity

Multivariate genome-wide analysis of aging-related traits

Exosomes secreted by mesenchymal stem cells delay brain aging in male accelerated aging mice

Aging impairs differentiation ability of vascular endothelial stem cells in mice

Genome-wide analysis identifies novel loci and new drug targets for healthy aging

Ether lipid biosynthesis promotes extended longevity in worms

Platelet factors enhance cognition in mice I

Platelet factors enhance cognition in mice II

A novel immune modulator controls longevity in flies

Epidemiology/Demography
Genetic variants on chromosome region 9p21.3 associated with extreme longevity in Ashkenazi

Review: Does early life adversity have adverse long-term health consequences in long-lived social mammals?

Review: Do longevity genes work by reducing hypertension?

Clinical
Improvement in cognition with lifestyle intervention in people with cognitive decline

Poor balance slows gait and increases energy cost of walking

Review: Geroscience can contribute to therapeutic strategies for older adults with cardiovascular diseases

Review: Could dietary restriction reduce periodontal disease?

Review: Hallmarks of aging in people living with HIV

Comparative Biology/Evolution
DNA methylation patterns associated with longevity in mammals

Apolipoprotein-ε4 associated with higher fecundity among the Tsimane people of Bolivia

Resting heart rate, somatic mutations and aging in mammals

Evolution of cancer-resisting and autophagy genes associated with long life in mammals

Universal DNA methylation age across mammalian tissues

Postreproductive female killer whales provide protection for male offspring

Preprint: Diet, plasma glucose, longevity and cancer prevalence across vertebrates

Review: Diverse strategies prevent cancer in large, long-lived mammals

Review: Thyroid hormones and the evolution of human longevity

Novel Organisms/Ecology
Female gray seals’ reproductive investment positively correlated with longevity

Epigenetic aging in cows is accelerated by milk production

Emerging Models
Novel primate model for the study of Alzheimer’s disease

Policy/Ethics
Geroscience and climate science: Oppositional or complementary?

Odd and Ends
Apartment-dwelling Turkish dogs shorter-lived than those living in single family homes

Does tourism contribute to healthy aging

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Aging Biology Update is brought to you by the UAB Nathan Shock Center and compiled by Kathleen Fischer, Jessica Hoffman, Heather Patterson, and Steven Austad. Subscribe to this newsletter .

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June 2024 ABU

Featured
Ketogenic diet induces p53-dependent cellular senescence in multiple organs in mice and serum senescence markers in people

Accumulating stochastic variation in purely simulated data is sufficient to build aging clocks

Killifish germline depletion affects wound repair and longevity in a sex-specific fashion

Basic Biology
Quantification of healthspan in aging mice: introducing FAMY and GRAIL

Sexually antagonistic effects of 16-hydroxyestriol and late-start canagliflozin on ITP mouse longevity

Epigenetic aging from a single-cell perspective

Lifelong persistence of nuclear RNAs in the mouse brain

A lipidome landscape of aging in mice

Aging atlas reveals cell-type-specific effects of worm longevity increasing genetic mutations

Mice stressed by cold (22oC) laboratory conditions have three-fold higher gut transit time than unstressed mice maintained at thermal neutral temperature (30oC)

Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling accelerates cellular aging via mitochondrial dysfunction

Energetic cost of biosynthesis: a missing link between growth and longevity in mammals?

Male-specific behavioral and transcriptomic changes in aging worm neurons

Gonadal sex, sex steroids and sex chromosomes influence mouse cardiac aging

Single-cell and single-nucleus muscle atlas of aging

Polr3b heterozygosity in mice affects health, but not lifespan, in a sex and organ specific manner

Human white matter trajectories over the lifespan

Temporal coherence of circadian metabolome across tissues disrupted in aging male mice

Human telomere length is chromosome end–specific

Review: Cause or coincidence: aging and cancer

Review: Mitophagy in aging, health and disease

Review: Alterations of the blood-brain barrier during aging

Review: Replication stress in cellular senescence and aging

Contrary or Null Findings
Dietary restriction fails to extend lifespan of Drosophila model of Werner syndrome

Elders (> 80) with broken wrists have a lower mortality rate than age- and gender-matched controls

RCT finds no impact on grip strength of increased protein intake in older adults in a 12-week trial

Senolytic treatment fails to prevent cognitive decline in a female F344 rats

Few relationships between alcohol use and brain macrostructure found in older (70-90) low-level drinkers

Review: Deprescribing interventions have no significant impact on reducing Drug Burden Index or improving outcomes

Energetics/Nutrition
Counting steps instead of counting minutes for healthy longevity

Diet correlated with DunedinPACE epigenetic clock age and risk of dementia

Food insecurity and epigenetic aging in middle-aged and older adults

Time-restricted feeding improves aortic endothelial relaxation in aged mice

Complex lipid signature marks human muscle aging and responds to short-term exercise

Review: Amino acid restriction, aging, and longevity

Opinion. Adipose tissue as a linchpin of organismal ageing

Epidemiology/Demography
Infertility associated with incidence of postmenopausal breast cancer largely through age at first term pregnancy

Association of race, ethnicity, and socioeconomic status on the severity of menopause symptoms

Pregnancy complications associated with higher mortality risk >40 years later

Physical and cognitive function — not age — are key predictors of heat-related mortality

Systolic blood pressure <130 associated with longevity in older women

Traditional Mexican diet associated with lower cancer risk among women of Mexican descent

Unique microRNAs associated with exceptional longevity

Development and validation of an intrinsic capacity score in the UK Biobank study

Can retirement be deadly: a demographic analysis

Transition from low-to-high or high-to-low SES impacts dementia risk more than stable SES category

Reduced childhood mortality correlated with extended maternal lifespan

Global Burden of Disease study details greater morbidity for women across the life course, greater mortality for men

Edible cannabis legalization associated with significantly increased cannabis poisoning in older Canadian adults

Preprint: Quantifying individual- and population-level differences in rate of aging-related health declines

Clinical
Health advice for postmenopausal women from the Women’s Health Initiative trials

Female and male Medicare patients have lower patient mortality when treated by female physicians

Antipsychotics use in people with dementia associated with greater risk of adverse outcomes than expected

Geriatric depression: what clinicians need to know

Predictors of mortality shortly after entering a long-term care facility

Auditory processing but not peripheral hearing differs in older adults with and without mild cognitive impairment

Menopause depression: Under recognized and poorly treated

Review: Clinical challenges in the treatment of hypertension among aging adults

Review: Association of chronic pain with dementia

Review: Prognostic value of clinical assessments for older people

Evolution/Comparative
Are brain size and fidelity of double strand-break repair coevolving?

Selection for longer life and sex-specific reproductive costs in a 20th century population

Does effective population size govern evolutionary differences in telomere length?

Naked mole-rat mortality rates do not increase with age

Reproduction and post-reproductive lifespan in honeybee workers

Review: Extreme longevity: evolutionary implications

Review: Comparing species responses to putative life-extending pharmacological interventions

Perspective: Costs and benefits of molecular turnover with respect to health and aging

Novel Organisms
Nice Japanese quail have longer telomeres and longer lives than nasty quail

Telomere length is longer following diapause in two solitary bee species

Maternal age effects on offspring lifespan and reproduction among rotifers

Meeting abstract: Enhanced DNA damage response in Myotis bats

Caregiving
Parental health disproportionately affects female employment in China

Resource: Online tool to help manage neuropsychiatric symptoms of dementia

Policy/Ethics
Universal palliative care for healthy longevity

Changes in Medicare/Medicaid coverage could cost thousands of lives without saving as much money as expected

Caregivers, unseen, un- or underpaid and overwhelmed

Telehealth expansion increases clinical encounters but may not improve outcomes

Caring for an aging US population

Commentary
The lifespan-healthspan gap Is the greatest health challenge of the 21st century

Should the social “exposome” be incorporated into geroscience research?

Agent-based modeling: a tool to overcome some limits of randomized control trials

What frailty can tell us about aging well

Where angels fear: the complexity of cellular senescence

Odd and Ends
Does geroscience have a white hat bias problem?

People who visit senior centers are more likely to get regular health check-ups

1st known cancer treatment discovered on 4600-year-old Egyptian skull

Medicalization of old age

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Aging Biology Update is brought to you by the UAB Nathan Shock Center and compiled by Kathleen Fischer and Steven Austad