So, I decided to aggressively work towards improving my body composition and reduce (any) insulin resistance a few months ago.
I’ve deployed all the pharmaceuticals I mention in my question to this end.
I did have fatigue issues at some point with semaglutide, for which vitamin B supplementation, L-carnitine, and creatine were somewhat helpful. But otherwise, I have so far not found any issues being simultaneously on multiple “diabetes medications” at the same time, even though I am not diabetic.
I take SGLT-2 inhibitors (up to 200mg canagliflozin or 25mg empagliflozin) prior to sugary/carb-y meals, and acarbose (up to 100mg) if it also has starch. Alongside, I’ve been taking semaglutide at around 0.25mg a week to help achieve a better BMI (and reduce visceral fat). I top it with berberine (250-500mg) in case I’ve overeaten on a sedentary day.
I also try to use psyllium fiber immediately before meals when I can, and I try to get some regular exercise.
All this considered, I am wondering if you would add anything else to maximize effectiveness?? I recently considered DPP4 inhibitors which also stimulates GIP as something to combine with semaglutide, but I need to research more about this because I’m wary of interactions along the GLP-1 pathway. Sulfonylureas are a no-go because they can cause hypoglycemia.
The doses and combinations I use are very context dependent, and vary on a day-to-day basis. Generally though, I try to be low-carb :o