"Dietary restriction remains one of the most reproducible lifespan-extending interventions in the lab – but its effects depend on more than nutrient intake alone. In C elegans, researchers have shown that food-associated sensory cues can modulate the same longevity circuitry that dietary restriction engages, pointing to a brain-to-gut pathway that helps determine whether lifespan extension is realized.
New research suggests that longevity may hinge on something surprisingly ordinary: how the body senses its environment. In a pair of recent studies, scientists uncovered what amounts to a hidden switch – one that can turn the benefits of longevity on or off, without changing calories at all…"
https://longevity.technology/news/scientists-find-a-sensory-switch-for-longer-life/