I’m not sure I understand the implication. They were asked about the work and mentioned that they were taking the intervention themselves. That doesn’t constitute evidence that it works, obviously, but neither does mentioning it strike me as particularly suspicious.
The interesting question is whether the underlying biology is sound and whether the data eventually support the claims.
I think that it shows they have some confidence in their new drug combination in terms of safety at least… so I’m not surprised they are doing this, and telling people.
Richard Miller is in a different situation; he works for the government and the NIA doesn’t want to be seen to be promoting drugs off-label that haven’t been tested in rigorous studies (oriented towards longevity). I can understand why Richard Miller won’t say what he’s taken or not taken.
But for Irina Conboy who is no longer associated with UC Berkeley (only her company) she doesn’t have to worry about academic or govt. constraints that Richard Miller would.
If it is in fact two already approved medications, then cost should be reasonable.
I’m pretty sure it won’t be too hard to find out how much it is. Just contact the clinic they’re working with.
It is possible that it’s a mixture of biologics, and that can be really pricey.
In the Matt Kaeberlein interview on 30th July Irina Conboy claimed to have invented a new aging clock that doesnt have all the drawbacks of the existing eipigenetic clocks. This sounded much more convincing. You would have thought they would have been talking about the results of the 2 drug combo on this new aging clock by now? But i guess maybe “we tested a drug combo we developed using a clock we also developed” wouldn’t seem that convincing and it has only been a month.
Too bad the Conboys are chasing money. Their work on neutral blood exchange, showing the positive effects of replacing a portion of old plasma with saline, seemed very promising. Needed follow-up to assess dosing and frequency as it could very be that periodic FREE plasma donation (about 25% of plasma removed) could have some of these same positive effects as NBE.
Alternatively it could be that they decided it was not going to be that effective.
A recent presentation from the company (last Friday):
A Generally very content & data lite presentation. Here are the slides below from screen shots:
They talk about how they tested it on themselves (8 of them):
They each had a total of 51 tubes of blood drawn. It seems safe in this short term trial.
They see higher IGF-1 as a good thing (which is a point of contention with many longevity researchers).
And IGF-1 Was increased in all users of their new drug combination:
Uploading: Screenshot 2026-09-01 at 4.50.22 PM.png…
They have a number of testimonials (from mostly their employees):
Irina Conboy says she doesn’t need her driving glasses any more, after using the drug combo.
And they say anyone can join now using this registration QR code:
Some Commentary from a longevity leader, Michael West:
Matt Kaeberlein’s response:
Kaeberlein Podcast/ Interview with Conboy / Su: Matt Kaeberlein's New Longevity Science Podcast / Youtube Channel (2026) - #39 by RapAdmin
It’s bizarre. Share with family and friends? Share what? There’s no published research, no trials. I guess we are offered to take their word for it. Cannot wait to learn more. Intriguing for sure.
A unicorn in the making? Marketing 101 in the new world?
How to Rule the World: An Education in Power at Stanford University by Theo Baker
Generally when you launch a new product you present the most compelling data you can pull together. If this is the most compelling data… It makes you go hmmmm…
One of the slides declares, “People care about improvements they can FEEL,” placing the key word in all caps. As body builders say, in a mocking tone, “It’s all about the feelz.”
So the most defensible educated guess (per my AI research) is:
Drug 1: Fresolimumab (pan–TGF‑β neutralizing antibody)
Drug 2: Oxytocin (or an oxytocin‑pathway agonist)
Oxytocin was my first guess. But they said it wasn’t in the combination, and it has a very short half-life. I did some research and there’s a synthetic called Carbetocin, which hits the same mechanism, but that’s not a generic. The other thing is that the life extension only worked in male mice with the oxytocin combination and didn’t work for females. I guess we’re all just going to have to wait.
