5 Amino 1 MQ - Thoughts

I’m really interested to hear what experience, words of warning, and personal good/bad, apart from the wallet biopsy of the expense, people have had with 5-amino-1MQ.

There is a lot of hype and discussion around optimization of NAD, and this seems like an interesting method with a nicotinamide N-methyltransferase agent.

Furthermore, how would you choose to use it with Rapamycin - in recovery (e.g. day 3-7) or during the time your MTORC1 is maximally inhibited, or continuously? And if you have an opinion, what is the rationale?

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Seems people are using it for weight loss…

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Certainly, 5-amino-1MQ seems to support burning fat for energy while maintaining muscle mass.

The activation of SIRT1 by increasing NAD+ suggests it could be a good option as part of an anti-aging protocol.

Do you know of reliable and available sources for 5-amino-1MQ?

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I don’t know if this a trusted supplier, I’ve never used them before and I’ve never taken 5-amino-1MQ

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There are multiple suppliers, I suspect I can find some that are properly confirmed for human use on my side, as I know some doctors are prescribing it.
I’m curious in the setting of NAD optimization (whether through this mechanism, NMN,NR or others), whether individuals are approaching this in a cyclic fashion with their rapamycin, and if so are they doing it in recovery from MTORC1 inhibition or continuously or on some other basis?

This is a reputable supplier https://www.limitlesslifenootropics.com/

No affiliation

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Thanks for that - this seems a good source.

I heard some functional medicine doctors in a talk have an extensive discussion around how excellent this peptide was … and the literature is interesting.

I’m hoping to hear from someone even in regard to their approach to NAD boosters, regardless of type and their rationale and pattern of use of these agents in conjunction with Rapamycin.

The 2 are certainly used commonly together, and there are some smart folks on this board, there must be some ideas in this space.

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I take a NAD booster, 1 g of NMN powder (DNA) mixed in EVOO daily. It provides an energy boost and prevents a lot of fatigue. When I travel (usually 21+ hours) I take it when I land and I don’t experience any jetlag. It’s an amazing substance for healthspan as I rarely feel fatigued when I am not sick. The jury is still out for lifespan.

I believe you want higher NAD, but not too high. The rationale can be found here:

@DeStrider Is this where you order the product? Thanks.

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Yes. That’s it. I buy the NMN powder. Make sure you use a discount code for 10% off.

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I tried NMN, NR and niacin and using currently niacin from time to time: Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy.

Also, Niacin assists in creatine supplementation (depending on your MTHFR) : creatine synthesis uses S-Adenosyl Methionine (SAMe) as a methyl donor. SAMe is critical for methylation processes in the body. When you supplement with creatine, it can reduce the demand for endogenous creatine synthesis, potentially leading to an excess of SAMe and consequently, an overmethylated state. Niacin can help regulate this balance. After donating a methyl group, SAMe becomes homocysteine. Niacin contributes to the conversion of homocysteine back into methionine, which can then be transformed into SAMe again, helping to maintain a balance in the methylation cycle.

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How often are you dosing? Study is 750-1000 mg qd. Is the flushing not worse with non qd dosing? Does niacin really affect the atherogenic potential of lipids for the negative? Great find thanks for posting.

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Hi @Jeff_A, welcome to the forum! For a detailed exploration of NMN vs Niacin, I recommend Dr. Brad Stanfield’s summary, which you can find here: NMN vs Niacin.

As for my personal regimen, I’m currently taking 100mg of niacin daily, specifically in its nicotinic acid form. This variant is well-known for causing a “flush,” a response due to its effect on prostaglandin signaling, which leads to vasodilation.

However, a key point to consider is that niacin, particularly at higher doses, utilizes a biochemical pathway that involves methylation, a crucial process in which methyl groups are transferred for various critical physiological functions. To support this pathway and maintain a healthy balance of methyl donors in the body, I supplement with 500-1000mg of Trimethylglycine (TMG), especially on days when I am not training.

On workout days, my routine includes creatine supplementation. Creatine is not only beneficial for muscle energy but also acts as a methyl donor (through pathway, which I have described above). Due to this property of creatine, it helps in replenishing the body’s methyl pool, thereby reducing the necessity for additional TMG on these days.

Thank you for your remark, looked into it only afterwards. From one side: Niacin Increases Atherogenic Proteins in High-Density Lipoprotein of Statin-Treated Subjects . From other side: Niacin shows plaque regression . So, as always, the answer is: it depends.

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Thank you for the response, the welcome and the share. I take TMG 3 gm po qd, creatine 5 gm resistance training days, LEF Homocysteine Assist, niacinamide at 50 mg and have 1 copy MTHFR. Your dose is only 1/8-1/10 of the dose listed in the study. Have you had your NAD+ levels tested at 100 mg? Any evidence that 100 mg nicotinic acid has efficacy in restoring NAD+?

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@Jeff_A, valid point. You’re right to point out that my current dose is substantially lower than what’s cited in the study. I haven’t tested my NAD+ levels at the 100 mg dose, so I can’t confirm its efficacy at this level.

Regarding NAD+ and longevity, I have some personal skepticism. There’s a lack of conclusive evidence in current longevity studies about the direct impact of NAD+ supplementation to max/median lifespan. My approach is more intuitive. I believe in the importance of a healthy lifestyle, including exercise, balanced diet, and sun exposure moderation, to naturally support NAD+ levels.

In study, the level of whole blood NAD+ was increased by supplementation by 7.1-fold in the study group and 5.7 in the control group after 4 months compared to the participants’ baseline. While my dose is much smaller, I’m inclined to think that even a minor systemic supplement of nicotinic acid might help maintain NAD+ levels to a certain degree. If an opportunity arises to test my NAD+ levels, I’ll consider it and may adjust my dose based on the findings.

If you will find some insights to dosage/impact in future: would appreciate your feedback.

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I guess we just should quit being lazy and measure, LOL. I measure everything else. But I agree w/ both your skepticism and intuitive approach thus greatly appreciate the feedback. I haven’t measured either honestly because I’m not sold.

I have purchased 5-amino 1 mq from limitless life nootropics. I’m expecting my shipment in a week or so. I have am going down this road because I have literally tried everything in the last 25 years to manage my weight. I have not been able to identify the disfunction in my metabolism other than I’m hypothyroid and have struggled with getting that optimized. I definitely don’t fit into the “norm” with dosing. I was on NDT Armour for 20 years with still many symptoms and have only started to feel decent recently when switching to plain T4 only (opposite of what everyone says you should have T4 + T3). Anyway, I have disfunction but cannot figure it out. I was always tall and thin, my family members are tall and thin but constant weight gain, constant battle for me. I was underweight according to BMI when I was about 30 yo, but have steadily gained and gained. The only way I could lose weight is strict no carb, which is not healthy. I am drawn to 5-amino because the mechanism is that it is a NNMT inhibitor. When you are fat, you have more NNMT, so my hope is that inhibiting NNMT will allow me to lose a bit and then will have less NNMT. It is an experiment, but seems worth it to me to try since there seems to be low occurrence of side effects as well. I am planning on taking 50mg 3x daily. I bought the bulk powder (9grams) and plan to use it to completion (~60 days). Would love to hear about others using it but it seems like not a lot of people have used it. Limitless Life also has a number of other peptides that seem interesting:MOTS-C, Humanin. I’m also not sure about GLP-1’s since I’ve read they make you lose muscle mass and the whole reaction to the digestive system is concerning to me.

I’d think a detailed consultation would be in order to sort this out.
Glps are consistent in their success… but are being managed indiscriminately.
Muscle mass loss as part of body composition is avoidable, but needs a plan.

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Another NNMT inhibitor that looks interesting is 1-MNA. I don’t know much more than I could find with a google search but it’s been mentioned a couple of times here.

https://ohphealth.com/products/endoteliol-1mna?variant=44143499739427

Here’s where it was talked about by Dr. Yurth - @Elizabeth
https://www.rapamycin.news/t/niacin-revisited-helpful-or-harmful-in-cardiac-health/12263/43?u=ng0rge

And here’s an interview with Dr. Yurth by @RapAdmin 's favorite presenter, Dave Asprey. Don’t worry she’s very scientific and knowledgeable. It’s mostly about spermidine but if you go to the 58:00 minute mark, you can watch the few minutes that she talks about 1-MNA and NAD.

https://www.youtube.com/watch?v=HWZZFeYyBpw

Hope I don’t get banned for posting something with Dave Asprey in it…I’d have to join @SNK in Siberia.

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Here’s just a little info on 5 Amino 1 MQ.

5-amino-1MQ is a small molecule drug that functions to block the activity of an enzyme called nicotinamide N-methyltransferase (NNMT). NNMT plays a significant role in metabolism and energy and is predominantly active in fat tissue. By blocking NNMT, 5-amino-1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1). SIRT1 is also known as ‘the longevity gene’ because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.

It is a potentially superior treatment option for individuals suffering from (or who are at risk for) type II diabetes and other metabolic comorbidities to obesity. Furthermore, the activation of SIRT1 by an increase in NAD+ suggests 5-amino-1MQ is a good option for patients who are looking to develop a comprehensive
anti-aging protocol.

5 Amino 1 mq is an organic compound found in numerous food sources such as legumes, nuts, avocado, eggs, salmon, and berries. It is also classified as an non-essential branched-chain amino acid (BCAA), which are believed to play an important role in fat metabolism and energy balance.

Specifically, research has explored how 5 Amino 1 mq works to reduce inflammation and stimulate thermogenesis—a process that helps the body burn calories more efficiently.

At its core , 5 Amino 1 mq acts as a selective inhibitor of enzymes known as MAO-A. In particular, it blocks levels from being broken down during digestion – preventing any metabolites from entering the bloodstream after they are ingested orally or injected subcutaneously.

This inhibition has been linked to improved metabolic performance , increasing fat metabolism while also reducing lactic acid buildup in muscles after physical activity.

The cellular metabolism of 5 amino 1mq consists primarily of its conversion into metabolites such as homocysteine thiolactone (HCTL) which is then used by cells to fuel energy production or building muscle mass.

Animal studies have shown this process allows for efficient storage and utilization of dietary fats leading to increased fat burning benefits when combined with exercise. Additional evidence suggests that supplementation of HCTL may lead directly not only to greater weight loss but elevated levels of free testosterone — allowing athletes who often suffer from low testosterone levels due to weight loss diets get back into peak physical condition faster than before supplementing with HCTL.

https://focalpointvitality.com/5-amino-1-peptide/

https://www.prcpb.com/services/5-amino-1mq/

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